Aneti-glomerular lalo faʻamaʻi membrane

Anti-glomerular basement membrane faamaʻi (anti-GBM faʻamaʻi) o se le masani ai faʻamaʻi e mafai ona aofia ai vave vave faʻateteleina fatugaʻo faʻamaʻi ma mama mama.

O nisi ituaiga o faʻamaʻi e aofia ai na o le māmā poʻo le fatugaʻo. Aneti-GBM faʻamaʻi na lauiloa e taʻua o le Goodpasture syndrome.

Aneti-GBM faʻamaʻi o se autoimmune faʻaletonu. E tupu pe a osofai faʻasauā e le siama puipuia ma faʻaleagaina ai tino maloloina o le tino. O tagata e maua i lenei faʻamaʻi e atiaʻe ni mea e osofaʻia ai le polotini e taʻua o le collagen i tamaʻi 'ea' ea i totonu o mama ma vaega faamama (glomeruli) o fatugaʻo.

O nei vailaʻau e taua o antiglomerular basement membrane antibodies. O le glomerular basement membrane o se vaega o fatugaʻo e fesoasoani e faʻamama otaota ma faʻasili vai mai le toto. Antiglomerular basement membrane antivae o ni vaega teteʻe i lenei membrane. E mafai ona latou faʻaleagaina le potu i lalo o le fale, lea e mafai ona oʻo atu ai i le faʻaleagaina o fatugaʻo.

O isi taimi, o lenei faʻamaʻi e mafua mai i se siama respiratory respiratory pe e ala i le manava i solofanua hydrocarbon. I tulaga ia, e ono osofaʻia e le immune system ia totoga poʻo aano o le tino ona e sese ai i latou nei mo siama poʻo ni vailaʻau mai fafo.

O le tali atu sese a le tino puipuia mafua ai le toto i le ea taga o mama ma mumu i le totoga o vaega faamamaina.

Faʻailoga mafai ono tupu lemu i le tele o masina poʻo ni tausaga foi, ae e masani ona tupu vave i le tele o aso i vaiaso.

O le le lava o le fiaai, lelava, ma vaivaiga e masani lava vave auga.

O faʻamaʻi pipisi e aofia ai:

• Mauaina le toto
• Tale mama
• Manava le mānava

Fatugao ma isi faʻailoga aofia ai:

• Mimi toto
• Mu lagona pe a urination
• Faanoi ma puaʻi
• Paʻu paʻu
• Fula (edema) i soʻo se vaega o le tino, aemaise lava i vae

O se suʻesuʻega faʻaletino e ono faʻaalia ai faʻailoga o le toto maualuga ma le soona vai. E mafai e le tausi soifua maloloina ona faʻalogo i leo o le fatu ma mama pe a faʻalogo i le fatafata i le stethoscope.

O iʻuga urinalysis e masani ona le masani ai, ma faʻaalia ai le toto ma polotini i le miaga. E mafai ona vaaia sela mumu le masani ai.

O suʻega ia e ono ono faia:

• Antiglomerular maualalo suʻega membrane
• Kesi toto Arterial
• Loto
• Fatafata x-ray
• Creatinine (serum)
• Biopsy o le mama
• Biopsy o fatugaʻo

O le sini autu o le aveʻese o mea leaga o le tino mai le toto. Togafitiga ono aofia ai:

• Plasmapheresis, e aveʻese ai vailaʻau leaga e fesoasoani e faʻaititia ai le fulafula o fatugaʻo ma mama.
• O vailaʻau ole Corticosteroid (e pei ole prednisone) ma isi vailaʻau, e taofi pe faʻafilemuina le puipuiga o le tino.
• O vailaʻau e pei ole angiotensin-liliu mai o le elemene (ACE) mea faʻapipiʻi ma angiotensin receptor blockers (ARBs), e fesoasoani e taofiofia le toto.
• Dialysis, e mafai ona fai pe a fai e le toe mafai ona togafitia le fatu fatu.
• O le tuiina o fatugaʻo, lea e mafai ona faia pe a le toe aoga ou fatugaʻo.

Atonu e taʻu atu ia te oe e faʻatapulaʻa lau inuina o masima ma vai e faʻatonutonu ai le fulafula. I nisi tulaga, o le maualalo-i-feololo polotini taumafataga ono fautuaina.

O nei fesoasoani e ono maua ai nisi faʻamatalaga e uiga i le anti-GBM faʻamaʻi:

• National Institute of Diabetes ma Digestive ma Fatugaʻo Faʻamaʻi - www.niddk.nih.gov/health-information/kidney-disease/glomerular-diseases/anti-gbm-goodpastures-disease
• National Kidney Foundation - www.kidney.org/atoz/content/goodpasture
• National Organization for Rare Disorder - rarediseases.org/rare-diseases/goodpasture-syndrome

O le vave iloa e taua tele. O le vaʻaiga e sili atu le leaga peʻa o fatugaʻo ua uma ona matua faʻaleagaina pe a amata togafitiga. O le afaina o le mama e mafai ona amata mai i le agamalu i le ogaoga.

Tele tagata e manaʻomia le faʻamama toto poʻo le tuiina o fatugaʻo.

Le togafitia, o lenei tulaga mafai ona taʻitaʻia ai soʻo se tasi o mea nei:

• Faamai o le fatugao faaumiumi
• Iuga-tulaga fatugaʻo faamaʻi
• Le manuia le mama
• Faʻasolosolo alualu i luma glomerulonephritis
• Ogaoga le papala o le toto (oso toto)

Valaʻau mo sau feiloaʻiga ma lau tautua pe a fai o loʻo e faʻaaluina le tele o miaga, pe i ai ni au faʻailoga o le anti-GBM faʻamaʻi.

Aua neʻi e sogi lemu pe faʻamoe suauʻu penisini i lou gutu, e faʻaaliali ai le māmā i soli soli a le hydrocarbon ma mafai ai ona mafua ai le faʻamaʻi.

Goodpasture syndrome; Faʻasolosolo alualu i luma glomerulonephritis ma pulumu le toto; Pulmonary Fatugao syndrome; Glomerulonephritis - paʻu toto

• Sapalai o le toto fatugaʻo
• Glomerulus ma nephron

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Phelps RG, Turner AN. Aneti-glomerular maualalo faʻamaʻi membrane ma faamaʻi Goodpasture. I le: Feehally J, Floege J, Tonelli M, Johnson RJ, eds. Faʻamatalaga auʻiliʻi. 6th ed. Filatelefia, PA: Elsevier; 2019: chap 24.

Radhakrishnan J, Appel GB, DʻAgati VD. Maualuga glomerular faʻamaʻi. I: Yu ASL, Chertow GM, Luyckx VA, Marsden PA, Skorecki K, Taal MW, eds. Brenner ma Rector's Le Fatugaʻo. 11th lomiga. Filatelefia, PA: Elsevier; 2020: chap 32.