Sclerosing cholangitis

Sclerosing cholangitis e faʻasino i le fulafula (fulafula), maʻila, ma le faʻatamaʻiaina o gaʻo gaʻo i totonu ma fafo atu o le ate.

O le mafuaʻaga o lenei tulaga e le o iloa i le tele o tulaga.

O le faʻamaʻi ono mafai ona vaʻaia i tagata o loʻo i ai:

• Faamai fulafula toto (IBD) pei o ulcerative colitis ma Crohn faamaʻi
  
• Faʻafitauli o le autoimmune
• Pancreatitis faaumiumi (papala pancreas)
• Sarcoidosis (o se faʻamaʻi e mafua ai le fulafula i vaega eseese o le tino)

O mafuaʻaga faʻavae e ono ono gafa foi. O le sclerose cholangitis e tupu soo i tane nai lo fafine. E seasea tupu lenei faʻamaʻi i tamaiti.

Sclerosing cholangitis mafai foi ona mafua mai i:

• Choledocholithiasis (gallstones i le alatoto)
• O faʻamaʻi pipisi i le ate, gallbladder, ma le sela o le papala

O faʻailoga muamua e masani lava:

• Le lavava
• Mageso
• Lanu samasama o le paʻu ma mata (jaundice)

Peitai, o nisi tagata e leai ni faʻailoga.

O isi faʻailoga e mafai ona aofia ai:

• Faʻateleina le ate
• Faʻalautele pupula
• Leai o le fiaai ma leiloa paʻu
• Toe fai vaega o le cholangitis

Tusa lava pe le maua ni faʻailoga i ni tagata, o faʻataʻitaʻiga ile toto e faʻaalia ai o loʻo leaga a latou galuega ile ate. E vaʻai lau tausi soifua maloloina mo:

• O maʻi e mafua ai faʻafitauli faapena
• O faʻamaʻi e masani ona aliaʻe ma lenei tulaga (aemaise ai lava le IBD)
• Maa maa

O suʻega e faʻaalia ai le cholangitis e aofia ai:

• Suʻega CT scan
• Laʻititi ultrasound
• Endoscopic retrograde cholangiopancreatography (ERCP)
• Biopsy o le ate
• Maneta resonance cholangiopancreatography (MRCP)
• Cholutanogram transhepatic faʻasolitulafono (PTC)

Toto faʻataʻitaʻiga aofia ate ate (o le ate galue tofotofoga).

O vailaʻau e mafai ona faʻaaogaina aofia ai:

• Cholestyramine (pei ole Prevalite) e togafitia ai le mageso
• Ursodeoxycholic acid (ursodiol) e faʻaleleia ai le galue o le ate
• Vitamini e mafai ona fofo i le gaʻo (D, E, A, K) e sui ai le mea na leiloa mai le faʻamaʻi lava ia
• Vailaau vailaʻau e togafitia ai faʻamaʻi i le alatoto

O nei taotoga auala e mafai ona faia:

• Faʻaofiina se uumi, manifinifi paipa ma se paluni i le pito e tatala ai vaapiapi (endoscopic paluni vaʻaia o faʻamalosia)
• Faʻaputuina o se alavai poʻo se paipa mo le faʻalauteleina (faʻatamaia) o le sela
• Proctocolectomy (aveʻesega o le kolone ma le tumutumu, mo i latou e maua uma ulcerative colitis ma sclerosing cholangitis) e le aafia ai le alualu i luma o le muamua sclerosing cholangitis (PSC)
• Tui i le ate

E faʻapea e fesuisuiaʻi le lelei o tagata. O le faʻamaʻi e iʻu ina atili ai ona tupuaga leaga i le aluga o taimi. O isi taimi e atiaʻe ai tagata:

• Ascites (faʻaputuina suavai i le avanoa i le va o le ufiufi o le manava ma manava totoga) ma varices (faʻalauteleina uaua)
• Biliary cirrhosis (fulafula o gaʻo toto)
• Le lelei le ate
• Le tumau jaundice

O nisi tagata e maua i faʻamaʻi o le sela o le papala e toe foʻi mai.

O tagata e maua i lenei tulaga e tele le ono aʻafia i le kanesa o le sela (cholangiocarcinoma). E tatau ona siakiina e le aunoa ma se suʻega faʻataʻitaʻi o le ate ma suʻega toto. Tagata o loʻo iai foʻi le IBD e ono tele se aʻafiaga ile maua ole kanesa ole kolone poʻo le faʻasoʻo ma e tatau ona iai faʻamaʻi taimi.

Faʻafitauli e ono aofia ai:

• Toto totoga o le esophageal
• Kanesa i totonu o le sela (cholangiocarcinoma)
• Cirrhosis ma le ate toilalo
• Siama o le biliary system (cholangitis)
• Faʻaitiitiina o gaʻo galu
• Vaivaiga faaletonu

Cholangitis Peraimeri sclerosing; PSC

• Polokalama Digestive
• Ala Bile

Bowlus C, Assis DN, Goldberg D. Peraimeri ma tulaga lua sclerosing cholangitis. I le: Sanyal AJ, Boyer TD, Lindor KD, Terrault NA, eds. Zakim ma Boyer's Hepatology. 7th ed. Filatelefia, PA: Elsevier; 2018: mata 43.

Ross AS, Kowdley KV. Peraimeri sclerosing cholangitis ma toe tupu pyogenic cholangitis. I totonu: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger ma le Fordtran's Gastrointestinal ma le Maʻi o le ate: Pathophysiology / Diagnosis / Management. 10 ed. Filatelefaia, PA: Elsevier Saunders; 2016: mata 68.

Zyromski NJ, Pitt HA. Le puleaina ole muamua sclerose cholangitis. I: Cameron JL, Cameron AM, eds. Togafitiga i le taimi nei. 12th lomiga. Filatelefia, PA: Elsevier; 2017: 453-458.