Factor XII (Hageman factor) le lava

Factor XII deficit o se tofi faʻaletonu e afaina ai le polotini (vaega XII) aofia ai i le faʻaputuga toto.

A e alu alu le palapala, e tupu se faʻasologa o tali i le tino e fesoasoani e faʻaputuputu ai le toto. O lenei faiga e taʻua o le coagulation cascade. E aofia ai faʻapitoa polotini valaʻauina coagulation poʻo clotting vala. Oe ono maua le maualuga avanoa o sili atu tafetoto pe afai o se tasi pe sili atu o nei mea leiloa o loʻo misi pe le o faʻagaioiga e pei ona tatau ai.

Factor XII o se tasi na mafuaʻaga. O le le lava o lenei mea e le mafua ai ona e puna toto i se tulaga le masani ai. Ae, o le toto e umi atu nai lo le masani ai e faʻapipiʻi i totonu o se suʻega paipa.

Vaega XII le atoatoa o se seasea maua faʻamaʻi.

E masani ona leai ni faʻailoga.

Factor XII deficit e masani ona maua pe a fai o le faʻaputuputuina o suʻega e faia mo le masani ona siaki.

O suʻega e mafai ona aofia ai:

• Vaega XII tofotofoga e fua ai le gaioiga a le mea XII
• Partial thromboplastin time (PTT) e siaki pe o le a le umi e alu ai mo le toto e faʻaputuputu
• Suʻesuʻega suʻesuʻe, o se suʻega PTT faʻapitoa e faʻamaonia ai le le lava XII

Togafitiga e masani ona le manaʻomia.

O nei punaoa mafai ona maua ai nisi faʻamatalaga e uiga i le tulaga XII le atoatoa:

• National Hemophilia Foundation - www.hemophilia.org/Bleeding-Disorder/Types-of-Bleeding-Disorder/Other-Factor-Deficiencies/Factor-XII
• National Organisation for Rare Disorder - rarediseases.org/rare-diseases/factor-xii-deficiency
• NIH Genetic and Rare Diseases Information Center - rarediseases.info.nih.gov/diseases/6558/factor-xii-deficiency

O le iʻuga e faʻamoemoe e lelei e aunoa ma se togafitiga.

E masani ona leai ni faʻalavelave.

E masani ona maua e le tausi soifua maloloina lenei tulaga pe a fai isi suʻesuʻega.

Lenei o se faʻamaʻi tofi. E leai se auala iloa e puipuia ai.

Le lava le F12; Hageman itu le atoatoa; Hageman uiga; Le lava le HAF

• Toto toto

Gailani D, Wheeler AP, Neff AT. E seasea maua i le coagulation mea taua. I: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Faavae Autu ma Faʻataʻitaʻiga. 7th ed. Filatelefia, PA: Elsevier; 2018: mata 137.

Hall JE. Hemostasis ma le toto coagulation. I le: Hall JE, ed. Guyton ma Hall Tusitusiga o Fomaʻi Faʻapitoa. 13th lomiga. Filatelefia, PA: Elsevier; 2016: mata 37.

Ragni MV. Faʻafitauli o le hemorrhagic: o le coagulation mea le atoatoa. I totonu: Goldman L, Schafer AI, eds. Faʻafomaʻi Goldman-Cecil. 25th lomiga. Filatelefaia, PA: Elsevier Saunders; 2016: mata 174