Tusitala: William Ramirez
Aso O Foafoaga: 21 Setema 2021
Faafouga Aso: 22 Ianuari 2025
Anonim
The Role of p53 in Cancer
Ata: The Role of p53 in Cancer

Anotusi

O le a le TP53 gaʻoa?

O se suʻega ole TP53 o loʻo suʻesuʻeina se suiga, ua taʻua o le fesuiaʻiga, i se ituaiga ua faʻaigoaina TP53 (tuma protein 53). O kenera o vaega faʻavae ia o lona tupuʻaga na tuʻufaʻatasia mai lou tina ma lou tama.

TP53 o se kenera e fesoasoani taofi le tuputupu ae o tumors. E lauiloa o le faʻaopopuina o le patu. O le genes suppressor gene e pei o taofi i luga o se taʻavale. E tuʻuina "taofi" i sela, ina ia latou le vave vavaeina. A iai sau suiga TP53, e ono le mafai e le kenera ona faʻatonutonu le tuputupu aʻe o ou sela. O le le faʻatonutonu o le tupu aʻe o sela e mafai ai ona maua i le kanesa.

O le TP53 suiga e mafai ona maua mai i ou matua, pe maua mulimuli ane i le olaga mai le siʻosiʻomaga pe mai se mea sese e tupu i lou tino i le taimi o vaevaega sela.

  • O le tofi TP53 tofi ua taʻua o le Li-Fraumeni syndrome.
  • Li-Fraumeni syndrome o se tulaga seasea tupuʻaga tulaga e mafai ona faateleina ai lou tulaga lamatia o nisi ituaiga o kanesa.
  • O nei kanesa e aofia ai kanesa o le susu, kanesa o ponaivi, kanesa o le toto, ma kanesa vaivai o ponaivi, e taʻua foi o sarcomas.

Mauaina (lauiloa foi o somatic) TP53 mutations e sili atu ona taatele. O nei suiga ua maua i le afa o mataupu uma o le kanesa, ma i le tele o ituaiga o kanesa.


Isi igoa: TP53 mutation analysis, TP53 atoa gene analysis, TP53 somatic mutation

O le a le mea e faʻaaoga ai?

O le suʻega e faʻaaoga e vaʻai ai mo se suiga TP53. E le o se tofotofoga masani.E masani lava ona tuʻuina atu i tagata faʻavae i talaʻaga o aiga, faʻailoga, pe faʻamaonia muamua o le kanesa.

Aisea ou te manaʻomia ai se TP53 gafa faʻavae?

Atonu e te manaʻomia se suʻega TP53 pe a fai:

  • Ua uma ona maua oe ile ponaivi poʻo le vaivai i le kanesa i luma o le 45 tausaga
  • Ua uma ona maua oe ile kanesa ole susu, a o le i faiai le kanesa, kanesa o le toto, poʻo le kanesa o le mama ae e te leʻi 46 tausaga.
  • E tasi pe sili atu au faʻamaʻi ae e te leʻi 46 tausaga
  • Tasi poʻo le sili atu o tagata o lou aiga ua faʻamaonia e maua i le Li-Fraumeni syndrome ma / pe na maua i le kanesa ae leʻi 45 tausaga.

Nei o faʻailoga oe ono i ai se tofi suiga o le TP53 gafa.

Afai ua faʻamaonia oe i le kanesa ma e leai sau talaʻaga aiga o lenei faʻamaʻi, e ono poloaʻia e lau tausi soifua maloloina lenei faʻataʻitaʻiga e vaai pe o le TP53 suiga e ono mafua ai lou kanesa. O le iloa pe o iai sau fesuiaʻiga e mafai ona fesoasoani i lau tautua e fuafua togafitiga ma vaʻai le ono tupu o lou faʻamaʻi.


Ole a le mea e tupu ile taimi ole TP53 gafa?

O le faʻataʻitaʻiga TP53 e masani ona faia ile toto poʻo ponaivi ponaivi.

Afai o fai sau suʻega ile toto, o se polofesa mo le soifua maloloina o le a ave se toto faʻataʻitaʻiga mai se uaua i lou lima, faʻaaoga ai se tamaʻi nila. A maeʻa ona tuʻu i totonu le nila, o le a faʻaputuputuina se vaega laʻititi o le toto i totonu o se faʻamaoniga poʻo se ipu. Atonu e te lagonaina sina tiga pe a alu le nila i totonu pe fafo. Lenei masani ona alu ifo i lalo o le lima minute.

Afai o loʻo fai sau suʻesuʻega ivi, lau faʻagasologa e ono aofia ai laʻasaga nei:

  • Oe o le a taoto i lou itu po o lou manava, faalagolago i le ivi o le a faaaoga mo suʻega. Ole tele o ponaivi suʻega e suʻe mai le ponaivi ponaivi.
  • O lou tino o le a ufiufi i ie, ina ia na o le eria o loʻo faʻataʻitaʻia le nofoaga o loʻo faʻaalia.
  • O le 'upega tafaʻilagi o le a faʻamamaina i se vailaʻau.
  • Oe o le a maua se tui o se numbing fofo. E tiga.
  • O le taimi lava e le aoga le eria, o le tausi soifua maloloina o le a ave le faʻataʻitaʻiga. E tatau ona e taoto pea i taimi o suʻega.
  • O le soifua maloloina o le a faʻaaoga se mea faigaluega faʻapitoa e mimilo i totonu o le ponaivi e aveese se faʻataʻitaʻiga o ponaivi ponaivi ponaivi. Atonu e te lagonaina se faʻamalosi i luga o le upega tafailagi a o faia le faʻataʻitaʻiga.
  • A maeʻa le suʻega, o le a ufiufi e le tausi soifua maloloina le 'upega tafaʻilagi ma se fusi.
  • Fuafua e ave se tasi e momoli oe i le fale, talu ai atonu o le a tuʻuina atu ia te oe se faʻamalieina ae e leʻi faia suʻega, lea e ono mafua ai ona e fia moe.

Mata e tatau ona ou faia se mea e sauniuni ai mo le suʻega?

E masani ona e le manaʻomia ni sauniuniga faʻapitoa mo le toto poʻo le ponaivi suʻega.


E i ai ni lamatiaga i le suʻega?

E laʻititi lava le aʻafia ile faia ole suʻega ile toto. E i ai sina tiga poʻo se tiga i le mea na tuu ai le nila, ae o le tele o faʻailoga e vave ona alu ese.

A maeʻa le suʻega o ponaivi, e te lagona le maʻaʻa pe tiga foi i le nofoaga na tui ai. Lenei masani lava ona alu i ni nai aso. Atonu e fautuaina e lau fomaʻi lau fomaʻi pe e te faʻamamaina le tiga e fesoasoani.

O le a le uiga o faʻaiuga?

Afai na faʻamaonia e te maua i le Li-Fraumeni syndrome, e leai o lona uiga ua e maua i le kanesa, ae o lou lamatiaga e maualuga atu nai lo le tele o tagata. Ae afai e iai sau fesuiaʻiga, e mafai ona e uia laʻasaga e faʻaititia ai lou tulaga lamatia, pei o le:

  • Ole tele o taimi e siaki ai le kanesa. Kanesa e sili atu ona togafitia pe a maua i le amataga o laʻasaga.
  • Faia o suiga olaga, pei o le mauaina o le sili atu faamalositino ma 'ai i se maloloina maloloina meaai
  • O le Chemoprevention, o le inuina o vailaʻau, vitamini, poʻo isi vailaʻau e faʻaititia ai le aʻafia pe faʻatuai ai foʻi ona maua le kanesa
  • Aveʻese "i-tulaga lamatia" pepa solo

Nei laasaga o le a eseese faalagolago i lou soifua maloloina talaʻaga ma aiga talaʻaga.

A faʻapea e te maua i le kanesa ma o au faʻaiuga e taʻu mai ai le mauaina o le TP53 mutation (na maua se fesuiaiga, ae leai sau talaʻaga o le aiga o le kanesa poʻo le Li-Fraumeni syndrome), e mafai e lau tautua ona faʻaogaina faʻamatalaga e fesoasoani ai e valoʻia le auala e tupu ai lou maʻi ma faʻatonutonu ai lau faʻamaʻi. togafitiga.

Aʻoaʻo atili e uiga i suʻesuʻega falesuesue, vaitau o faʻasino, ma malamalamaaga i iʻuga

E iai se isi mea e tatau ona ou iloa e uiga ile suʻega TP53?

Afai ua faʻamaonia oe pe ua e masalomia o loʻo e maua i le Li-Fraumeni syndrome, e ono fesoasoani le talanoa i se faufautua o meaola. O se faufautua kenera o se faʻapitoa aʻoaʻoina faʻapitoa i genetics ma faʻasologa genetic. Afai e leʻi faʻataʻitaʻia oe, e mafai ona fesoasoani le fesoasoani ia te oe ia malamalama i mea lamatia ma penefiti o le suʻega. Afai na faʻataʻitaʻia oe, e mafai ona fesoasoani le fesoasoani ia te oe ia malamalama i iʻuga ma faʻasino oe i tautua lagolago ma isi mea taua.

Faʻamatalaga

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O faʻamatalaga i luga o lenei 'upega tafaʻilagi e le tatau ona faʻaaogaina e fai ma sui o fomaʻi faʻapitoa togafitiga poʻo fautuaga. Faʻafesoʻotaʻi le au tausi soifua pe a iai ni au fesili e uiga i lou soifua maloloina.

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