Vailaau Antiplatelet - P2Y12 tagata taofi

Platelet o sela laiti i lou toto e faʻaogaina e lou tino e fai ai faʻaputuga toto ma taofi le tafe. A faʻapea e tele naua au peleni poʻo ni au faʻamaumauga e pipii faʻatasi, o le a atili ai ona e faia ni toʻa. O lenei laei e mafai ona tupu i totonu o au alatoto ma taʻitaʻi atu ai i le fatu fatu po o le papala.

O vailaʻau faʻafomaʻi antiplatelet e galue e faʻapipiʻi ai au lapisi ma fesoasoani ai i le puipuia o faʻamalosi toto mai i ou alatoto.

• Aspirin o se vailaʻau antiplatelet e mafai ona faʻaaogaina.
• P2Y12 receptor blockers o seisi kulupu o antiplatelet vailaʻau. O lenei vaega o vailaʻau e aofia ai: clopidogrel, ticlopidine, ticagrelor, prasugrel, ma cangrelor.

Antiplatelet vailaʻau mafai ona faʻaaogaina e:

• Puipuia le faʻamaʻi fatu poʻo le papala mo latou e iai le PAD.
• Clopidogrel (Plavix, generic) mafai ona faʻaaogaina e sui aʻi aspirin mo tagata o loʻo faʻaititia o latou alatoto pe ua faʻaofi i ai se stent.
• O isi taimi o vailaʻau e 2 antiplatelet (o se tasi e toetoe lava a aspirin i taimi uma) e faʻatonuina mo tagata e le mautu le angina, maʻi o le coronary syndrome (le mautonu angina poʻo faʻailoga amata o le fatu faʻafuaseʻi), poʻo i latou na mauaina se manogi i le taimi o le PCI.
• Mo faʻamaʻi fatu muamua ma le lua faʻatonutonu, o le aspirin i aso uma o le muamua filifiliga mo antiplatelet togafitiga. O le Clopidogrel e faʻatonuina ae le o le aspirin mo tagata e maua i le aspirin e le taliaina le aspirin.
• Aspirin ma le vailaʻau antiplatelet lona lua e masani ona fautuaina mo tagata o loʻo feagai ma angioplasty pe i ai ma le le stenting.
• Puipuia pe togafitia fatu oso.
• Puipuia le afaina poʻo osofaʻiga le tumau ischemic (TIAs o lapataʻi lapataʻi o le stroke. Latou taʻua foi o "mini-stroke.")
• Taofi le toʻetoto mai i totonu stents tuu i totonu o ou alatoto e tatala ai i latou.
• Matuia coronary syndrome.
• A maeʻa ona vaʻaia le taotoga o togafiti e faʻaaoga ai se gaugofie na faia e le tagata poʻo le faʻafefeteina i luga o alatoto i lalo ifo o le tulivae.

O lau fomaʻi e filifili poʻo fea o nei vailaʻau e sili mo lou faʻafitauli. I taimi, oe ono talosagaina oe e ave maualalo inumaga aspirin faʻatasi ai ma se tasi o nei vailaʻau.

Aafiaga o lenei vailaʻau ono aofia ai:

• Manava tata
• Mageso
• Faanoi
• Paʻu mageso
• Manava tiga

Ae e te leʻi amata inuina nei vailaʻau, taʻu i lau tautua pe a fai:

• E maua oe ile faʻafitauli o le alu ile palapala ile papala ole papala.
• Ua e maʻitaga, fuafua e te maitaga, pe o faʻasusu oe.

E i ai le tele o isi ono aʻafiaga, faʻamoemoe i le vailaʻau na faatonuina oe. Faataitaiga:

• Ticlopidine ono taitai atu ai i le matua maualalo papaʻe sela sela poʻo se puipuia faʻafitauli e faʻaleagaina lapisi.
• Ticagrelor ono mafuaʻaga vaega o le puupuu o le manava.

O lenei vailaʻau e ave o se fualaʻau. E mafai e lau tautua ona suia lau fualaʻau mai lea taimi i lea taimi.

Ave lenei vailaʻau ma meaai ma tele vai e faʻaititia ai aʻafiaga. Atonu e te manaʻo e taofi le toe tago i le clopidogrel ae e te leʻi faia se taotoga poʻo se nifo. Aua le gata le taofia lou inuina o au vailaʻau e aunoa ma le muamua talanoa ma lau tautua.

Talanoa ma lau tautua ae e leʻi inuina se tasi o nei vailaʻau:

• Heparin ma isi toto manifinifi, pei o warfarin (Coumadin)
• Paʻu poʻo vailaʻau moʻi (e pei o diclofenac, etodolac, ibuprofen, indomethacin, Advil, Aleve, Daypro, Dolobid, Feldene, Indocin, Motrin, Orudis, Relafen, poʻo Voltaren)
• Phenytoin (Dilantin), tamoxifen (Nolvadex, Soltamox), tolbutamide (Orinase), poʻo le torsemide (Demadex)

Aua le tagofia isi vailaʻau atonu e iai le aspirin poʻo le ibuprofen i totonu o latou ae e te leʻi talanoa ma lau tautua. Faitau igoa i luga o vailaʻau malulu ma fulū. Fesili atu poʻo a isi vailaʻau e saogalemu mo oe e inu mo tiga ma tiga, malulu, poʻo le fulū.

Afai e i ai sau ituaiga o faʻatulagaina taimi faʻatulagaina, oe ono manaʻomia le taofi nei vailaʻau 5 i le 7 aso ae le i lima. Ae ui i lea, ia siaki i taimi uma ma lau tautua muamua pe saogalemu le taofi.

Taʻu i lau tausimaʻi pe a fai o oe o maʻito pe o fuafua e te maʻito, pe faʻasusu susu pe fuafua e faʻasusu. Tamaitai i le mulimuli laasaga o maitaga le tatau ona faia clopidogrel. Clopidogrel mafai ona pasi i pepe e ala i susu susu.

Talanoa ma lau tautua pe a fai oe maua i le ate poʻo le faʻamaʻi fatu.

Afai e te misia se fualaʻau:

• Ave i se taimi vave e mafai ai, seʻi vagana ua oʻo i le taimi mo lau isi fualaʻau.
• Afai ua oʻo i le taimi mo lau isi fualaʻau, ave lau masani masani.
• Aua le inuina ni fualaʻau faʻaopoopo e sui ai se fualaʻau ua e misia, seʻi vagana ua taʻu atu e lau fomaʻi.

Teu nei vailaʻau ma isi vailaʻau i se nofoaga malulu, mago. Taofi latou i mea e le mafai ona o iai tamaiti.

Valaʻau pe a iai ni ou faʻafitauli ae e le o ese.

• Soʻo se faʻailoga o le le masani ai o le tafetoto, pei o le toto i le miaga poʻo nofoa, isu o le isu, soʻo se tuʻiga e le masani ai, mamafa o le tafe mai le lavea, paʻu uliuli nofoa, tale i luga le toto, mamafa atu nai lo masani masani palapala toto poʻo le faʻatalitali fiva palapala, puaʻi e foliga mai o kofe
• Faanenefu
• Faigata faʻaumatia
• Mau i lou fatafata poʻo le tiga tiga
• Fula i ou foliga poʻo ou lima
• O le mageso, faʻagalue, poʻo le pisapisaō o ou foliga poʻo ou lima
• Wheezing pe faigata ona manava
• Leaga le manava tiga
• Paʻu mageso

Toto manifinifi - clopidogrel; Antiplatelet togafitiga - clopidogrel; Thienopyridines

• Laupapa faʻaputuga fale i alatoto

Abraham NS, Hlatky MA, Antman EM, et al. ACCF / ACG / AHA 2010 faʻamaumauga maliliega i luga o le faʻaaogaina tutusa o proton pump inhibitors ma thienopyridines: o se taulaʻi faʻafouina o le ACCF / ACG / AHA 2008 faʻapitoa maliega pepa i luga o le faʻaititia o gastrointestinal lamatiaga o antiplatelet togafitiga ma NSAID faʻaaogaina: o se lipoti o le American College of Cardiology Foundation Task Force i luga o Pepa o Maliega Faʻapitoa. J Am Coll Cardiol. 2010; 56 (24): 2051-2066. PMID: 21126648 pubmed.ncbi.nlm.nih.gov/21126648/.

Fihn SD, Blankenship JC, Alexander KP, et al. 2014 ACC / AHA / AATS / PCNA / SCAI / STS taulaʻi faʻafouina o le taʻiala mo le suʻesuʻeina ma le puleaina o tagata mamaʻi ma le mautu o le fatu ischemic faʻamaʻi: o se lipoti a le American College of Cardiology / American Heart Association Task Force i luga o Faʻataʻitaʻiga Faʻatonuga, ma le American Association for Thoracic Surgery, Preventive Cardiovascular Nurses Association, Sosaiete mo Cardiovascular Angiography ma Faʻalavelave, ma le Sosaiete a Thoracic Surgeons. Faasalalauina. 2014; 130: 1749-1767. PMID: 25070666 pubmed.ncbi.nlm.nih.gov/25070666/.

Goldstein LB. Puipuia ma le faʻatautaia o le faʻafitauli o le ischemic stroke. I: Zipes DP, Libby P, Bonow RO, Mann DL, Tomaselli GF, Braunwald E, eds. Braunwald's Heart Disease: O Se Tusitusiga o Faʻafomaʻi Cardiovascular. 11th lomiga. Filatelefia, PA: Elsevier; 2019: chap 65.

Ianuari CT, Wann LS, Alpert JS, et al. 2014 AHA / ACC / HRS taʻiala mo le puleaina o tagata mamaʻi ma atrial fibrillation: o se lipoti a le American College of Cardiology / American Heart Association Task Force i luga o Faʻataʻitaʻiga Faʻataʻitaʻiga ma le Heart Rhythm Society. J Am Coll Cardiol. 2014; 64 (21): e1-e76. PMID: 24685669 pubmed.ncbi.nlm.nih.gov/24685669/.

Mauri L, Bhatt DL. Fesoasoani faʻapitoa i mafuaaga lilo o maliu. I: Zipes DP, Libby P, Bonow RO, Mann DL, Tomaselli GF, Braunwald E, eds. Braunwald's Heart Disease: O Se Tusitusiga o Faʻafomaʻi Cardiovascular. 11th lomiga. Filatelefia, PA: Elsevier; 2019: chap 62.

Meschia JF, Bushnell C, Boden-Albala B, et al. Taʻiala mo le puipuiga muamua o le faʻamaʻi: o se faʻamatalaga mo fomaʻi polofesa mai le American Heart Association / American Stroke Association. Pa. 2014; 45 (12): 3754-3832. PMID: 25355838 pubmed.ncbi.nlm.nih.gov/25355838/.

Taeao DA, de Lemos JA. Maʻi fatu fatu ischemic I: Zipes DP, Libby P, Bonow RO, Mann DL, Tomaselli GF, Braunwald E, eds. Braunwald's Heart Disease: O Se Tusitusiga o Faʻafomaʻi Cardiovascular. 11th lomiga. Filatelefia, PA: Elsevier; 2019: chap 61.

Malosiaga WJ, Rabinstein AA, Ackerson T, et al. Taʻiala mo le vave faʻatautaia o tagata mamaʻi ma le afaina o le ischemic stroke: 2019 faʻafouina i le 2018 Taʻiala mo le vave puleaina o tagata mamaʻi ma le ogaoga o le ischemic stroke: o se taʻiala mo fomaʻi polofesa mai le American Heart Association / American Stroke Association. Pa. 2019; 50 (12): e344-e418. PMID: 31662037 pubmed.ncbi.nlm.nih.gov/31662037/.

• Angina
• Angioplasty ma stent tulaga - carotid alatoto
• Angioplasty ma stent tuu - peripheral alatoto
• Vaʻaia alatoto faʻasolosolo - laiti osofaʻiga
• Taotoga alatoto vaʻaia - matala
• Taotoga faʻamavae Cardiac
• Taotoga o le alatoto Carotid - matala
• Faʻamaʻi pipisi i lalo o le toto (COPD)
• Maʻi fatu fatu
• Heart bypass taotoga
• Heart bypass taotoga - minimally invasive
• Le lava le fatu
• Faʻamafanafana loto
• Ole toto maualuga ole toto maualuga
• Toto maualuga - tagata matutua
• Ma totoina cardioverter-defibrillator
• Mitral alatoto taotoga - minimally invasive
• Mitral alatoto taotoga - matala
• Peripheral artery bypass - vae
• Faamaʻi o alatoto eseese - vae

• Angina - faʻateʻaina
• Angioplasty ma stent - fatu - faʻateʻaina
• Angioplasty ma stent tulaga - carotid alatoto - faʻateʻaina
• Angioplasty ma stent faʻatulagaina - peripheral alatoto - faʻateʻaina
• Aspirin ma faʻamaʻi fatu
• Atrial fibrillation - faʻateʻaina
• Toaga pe a e maua i le fatu fatu
• Catheterization fatu - faʻateʻaina
• Taotoga o le alatoto Carotid - faʻateʻaina
• Faʻatonutonuina lou toto maualuga
• Maʻi suka - puipuia le faʻamaʻi o le fatu ma faʻamaʻi
• Maʻi fatu - faʻateʻa
• Taotoga alo i le fatu - faʻateʻa ese
• Taotoga alo i le fatu - laitiiti leaga osofaʻiga - lafoa o le tino
• Le lava fatu - faʻateʻa
• Taotoga alatoto fatu - faʻateʻaina
• Peripheral artery bypass - vae - lafoa
• Ta - faʻateʻa

• Tino Manifinifi