Antineutrophil Cytoplasmic Antibodies (ANCA) Suʻega

Anotusi

• O le a le faʻataʻitaʻiga ole antineutrophil cytoplasmic antibodies (ANCA)?
• O le a le mea e faʻaaoga ai?
• Aisea ou te manaʻomia ai se suʻega ANCA?
• Ole a le mea e tupu ile taimi ole suʻega ole ANCA?
• Mata e tatau ona ou faia se mea e sauniuni ai mo le suʻega?
• E i ai ni lamatiaga i le suʻega?
• O le a le uiga o faʻaiuga?
• E i ai seisi mea e tatau ona ou iloa e uiga i le ANCA suʻega?
• Faʻamatalaga

O le a le faʻataʻitaʻiga ole antineutrophil cytoplasmic antibodies (ANCA)?

Lenei suʻega vaʻai mo antineutrophil cytoplasmic antibodies (ANCA) i lou toto. Antibodies o polotini e faia e lou tino tetee e tetee atu ai i fafo mea e pei o siama ma siama. Ae ole ANCA osofaʻia sela maloloina na taʻua ole neutrophil (o se ituaiga sela paʻepaʻe) ma le sese. Ole mea lea e mafai ona tupu ai ile faʻamaʻi e taʻua ole autoimmune vasculitis. Autoimmune vasculitis e mafua ai le fulafula ma le fula o alatoto.

O toto e aveina le toto mai lou fatu i ou totoga, sela, ma isi faiga, ona toe foʻi ai lea. Ituaiga o alatoto toto aofia ai alatoto, alatoto, ma capillaries. O le fulafula i ala toto e mafai ona mafua ai ni faʻafitauli faigata i le soifua maloloina. O faʻafitauli e fesuisuiaʻi e fuafua i faʻafitauli o le toto ma le tino.

E i ai lua autu ituaiga o ANCA. Taitasi faʻatulagaina se faʻapitoa porotini totonu papaʻe sela toto:

• pANCA, lea e faʻatatau i le polotini e taʻua o le MPO (myeloperoxidase)
• cANCA, lea e faʻatatau i le polotini e taʻua o le PR3 (proteinase 3)

O le suʻega e mafai ona faʻaalia ai pe tasi pe lua uma ituaiga o vailaʻau. Ole mea lea e mafai ona fesoasoani i lau fomaʻi faʻapitoa e suʻesuʻe ma togafitia lou maʻi.

Isi igoa: ANCA anticodies, cANCA pANCA, cytoplasmic neutrophil antibodies, serum, anticytoplasmic autoantibodies

O le a le mea e faʻaaoga ai?

O se faʻataʻitaʻiga a le ANCA e masani ona faʻaaoga e iloa ai pe i ai sau ituaiga autoimmune vasculitis. E i ai ituaiga eseese o lenei faʻamaʻi. E mafua uma lava le fulafula ma le fulafula o alatoto, ae taʻitasi ituaiga afaina ai toto toto ma vaega o le tino. Ituaiga o autoimmune vasculitis aofia ai:

• Granulomatosis ma polyangiitis (GPA), na taʻua muamua ole faamaʻi ole Wegener. E masani ona aʻafia ai māmā, fatugaʻo, ma sinus.
• Polokalamaitis o le mikerosekope (MPA). O lenei faʻamaʻi e mafai ona aʻafia ai nisi totoga i le tino, e aofia ai mama, fatugaʻo, neula, ma le paʻu.
• Eosinophilic granulomatosis ma polyangiitis (EGPA), na taʻua muamua ole Churg-Strauss syndrome. O lenei faʻamaʻi e masani ona aʻafia ai le paʻu ma māmā. E masani ona mafua ai le sela.
• Polyarteritis nodosa (PAN). Lenei faʻamaʻi e masani ona aʻafia ai le fatu, fatugaʻo, paʻu, ma le faʻatupulaia o neula.

E mafai foʻi ona faʻaaoga se suʻega ole ANCA e siaki ai togafitiga o nei faʻamaʻi.

Aisea ou te manaʻomia ai se suʻega ANCA?

E mafai e lau tausi soifua maloloina ona poloa se faʻataʻitaʻiga ole ANCA pe a iai ni faʻailoga o le autoimmune vasculitis. Faʻailoga aofia ai:

• Fiva
• Le lavava
• Paʻu pauna
• Maso ma / pe tiga soʻoga

O au faʻailoga e ono aʻafia ai se tasi pe sili atu faʻapitoa totoga i lou tino. O totoga e masani ona aʻafia ma faʻailoga e mafua ai e aofia ai:

• Mata
  • Mumu
  • Faʻaaliga le malamalama
  • Leiloa se vaʻai
• Taliga
  • Tagi i taliga (tinnitus)
  • Leiloa faʻalogo
• Sinuses
  • Sinus tiga
  • Isu isu
  • Isu toto
• Paʻu
  • Rashes
  • Maʻi poʻo papala, o se ituaiga o loloto papala e telegese ona faʻamalolo ma / pe toe foʻi mai
• Papa
  • Mama
  • Faʻalavelave manava
  • Tiga o le fatafata
• Fatugaʻo
  • Toto i le miaga
  • Mimi feula, lea e mafua mai i porotini i le miaga
• Faiga popole
  • Le mageso ma taia i vaega eseese o le tino

Ole a le mea e tupu ile taimi ole suʻega ole ANCA?

O le polofesa mo le soifua maloloina o le a ave se toto faʻataʻitaʻiga mai se uaua i lou lima, faʻaaoga ai se tamaʻi nila. A maeʻa ona tuʻu i totonu le nila, o le a faʻaputuputuina se vaega laʻititi o le toto i totonu o se faʻamaoniga poʻo se ipu. Atonu e te lagonaina sina tiga pe a alu le nila i totonu pe fafo. Lenei masani ona alu ifo i lalo o le lima minute.

Mata e tatau ona ou faia se mea e sauniuni ai mo le suʻega?

E te le manaʻomia ni sauniuniga faʻapitoa mo se suʻega ANCA.

E i ai ni lamatiaga i le suʻega?

E laʻititi lava le aʻafia ile faia ole suʻega ile toto. E i ai sina tiga poʻo se tiga i le mea na tuu ai le nila, ae o le tele o faʻailoga e vave ona alu ese.

O le a le uiga o faʻaiuga?

Afai o au iʻuga na le lelei, o lona uiga o au faʻailoga atonu e le mafua mai i le autoimmune vasculitis.

Afai o lau iʻuga sa lelei, atonu o lona uiga o loʻo e maua i le autoimmune vasculitis. E mafai foʻi ona faʻaalia pe a maua cANCAs poʻo pANCAs. Lenei mafai ona fesoasoani fuafua pe o le a le ituaiga o vasculitis oe maua.

E tusa lava poʻo le a le ituaiga o vailaʻau na maua, oe ono manaʻomia se faʻaopoopoga suʻega, taʻua o le biopsy, e faʻamaonia ai le faʻamaoniga. O le biopsy o se auala e aveʻese ai sina tamaʻi vaega o sela poʻo sela mo suʻega. E ono faʻatonu foʻi e lau tausi soifua maloloina nisi suʻesuʻega e fua ai le aofaʻi ole ANCA i lou toto.

Afai o loʻo togafitia oe i le taimi nei mo le autoimmune vasculitis, o au iʻuga e ono faʻaalia pe o galue ou togafitiga.

A iai ni au fesili e uiga i au iʻuga, talanoa i lau fomaʻi.

Aʻoaʻo atili e uiga i suʻesuʻega falesuesue, vaitau o faʻasino, ma malamalamaaga i iʻuga

E i ai seisi mea e tatau ona ou iloa e uiga i le ANCA suʻega?

Afai o faʻaiuga a le ANCA o loʻo faʻaalia ai o loʻo ia oe le autoimmune vasculitis, e i ai auala e togafitia ai ma faʻatonutonu ai le tulaga. Togafitiga mafai ona aofia ai vailaʻau, togafitiga e aveese le tumau ANCAs mai lou toto, ma / poʻo taʻotoga.

Faʻamatalaga

1. Allina Soifua Maloloina [Initaneti]. Minneapolis: Soifua Maloloina Allina; Fuaina C-ANCA; [taʻua le 2019 Me 3]; [pe tusa ma le 3 pupuni] Avanoa mai: https://account.allinahealth.org/library/content/49/150100
2. Allina Soifua Maloloina [Initaneti]. Minneapolis: Soifua Maloloina Allina; Fuaina P-ANCA; [taʻua le 2019 Me 3]; [pe tusa ma le 3 pupuni] Avanoa mai: https://account.allinahealth.org/library/content/49/150470
3. Cleveland Clinic [Initaneti]. Cleveland (OH): Cleveland Clinic; c2019. O papala o vae ma vae; [taʻua le 2019 Me 3]; [pe tusa ma le 3 pupuni] Avanoa mai: https://my.clevelandclinic.org/health/diseases/17169-leg-and-foot-ulcers
4. Lab Tofotofoga lugalaina [Initaneti]. Washington D.C: American Association mo vailaʻau Togafitiga; c2001–2019. ANCA / MPO / PR3 Antibodies; [faʻafouina 2019 Aperila 29; taʻua le 2019 Me 3]; [pe a ma le 2 pupuni] Avanoa mai: https://labtestsonline.org/tests/ancampopr3-antibodies
5. Lab Tofotofoga lugalaina [Initaneti]. Washington D.C .: American Association mo Vailaʻau Togafitiga; c2001–2019. Biopsy; [faafou 2017 Jul 10; taʻua le 2019 Me 3]; [pe a ma le 2 pupuni] Avanoa mai: https://labtestsonline.org/glossary/biopsy
6. Lab Tofotofoga lugalaina [Initaneti]. Washington D.C .: American Association mo Vailaʻau Togafitiga; c2001–2019. Vasculitis; [faafou 2017 Sep 8; taʻua le 2019 Me 3]; [pe a ma le 2 pupuni] Avanoa mai: https://labtestsonline.org/conditions/vasculitis
7. Mansi IA, Opran A, Rosner F. ANCA-Associated Laʻititi-Ipu Vasculitis. Am Fam Doctor [Initaneti]. 2002 Aperila 15 [taʻua le 2019 Me 3]; 65 (8): 1615–1621. Avanoa mai: https://www.aafp.org/afp/2002/0415/p1615.html
8. Mayo Clinic Laboratories [Initaneti]. Mayo Faʻavae mo Aʻoga Faʻafomaʻi ma Suesuega; i1995–2019. ID faʻataʻitaʻi: ANCA: Cytoplasmic Neutrophil Antibodies, Serum: Clinical and Interpretive; [taʻua le 2019 Me 3]; [tusa o le 4 pupuni] Avanoa mai: https://www.mayocliniclabs.com/test-catalog/Clinical+and+Interpretive/9441
9. National Heart, Lung, and Blood Institute [Initaneti]. Bethesda (MD): U.S. Matagaluega o le Soifua Maloloina ma Tagata Auaunaga; Tofotofoga Toto; [taʻua le 2019 Me 3]; [pe tusa ma le 3 pupuni] Avanoa mai: https://www.nhlbi.nih.gov/health-topics/blood-tests
10. National Heart, Lung, and Blood Institute [Initaneti]. Bethesda (MD): U.S. Matagaluega o le Soifua Maloloina ma Tagata Auaunaga; Vasculitis; [taʻua le 2019 Me 3]; [pe a ma le 2 pupuni] Avanoa mai: https://www.nhlbi.nih.gov/health-topics/vasculitis
11. Radice A, Sinico RA. Antineutrophil Cytoplasmic Antibodies (ANCA). Autoimmunity [Initaneti]. 2005 Feb [taʻua le 2019 Me 3]; 38 (1): 93-103. Avanoa mai: https://www.ncbi.nlm.nih.gov/pubmed/15804710
12. Nofoaga Autu o Fatugao UNC [Initaneti]. Chapel Hill (NC): UNC Fatugaʻo Center; c2019. ANCA Vasculitis; [faafou 2018 Sep; taʻua le 2019 Me 3]; [pe tusa ma le 3 pupuni] Avanoa mai: https://unckidneycenter.org/kidneyhealthlibrary/glomerular-disease/anca-vasculitis

O faʻamatalaga i luga o lenei 'upega tafaʻilagi e le tatau ona faʻaaogaina e fai ma sui o fomaʻi faʻapitoa togafitiga poʻo fautuaga. Faʻafesoʻotaʻi le au tausi soifua pe a iai ni au fesili e uiga i lou soifua maloloina.