BCR ABL Genetic Test

Anotusi

• O le a le suʻega ole gaʻo ole BCR-ABL?
• O le a le mea e faʻaaoga ai?
• Aisea ou te manaʻomia ai se BCR-ABL ituaiga faʻamaoniga?
• Ole a le mea e tupu ile taimi ole suʻega ole gaʻo ole BCR-ABL?
• Mata e tatau ona ou faia se mea e sauniuni ai mo le suʻega?
• E i ai ni lamatiaga i le suʻega?
• O le a le uiga o faʻaiuga?
• E i ai seisi mea e tatau ona ou iloa e uiga i le BCR-ABL gaʻoa keni?
• Faʻamatalaga

O le a le suʻega ole gaʻo ole BCR-ABL?

O le suʻega ole BCR-ABL o loʻo suʻesuʻeina se fesuiaʻiga o sela (suiga) i luga o le chromosome.

Chromosome o ni vaega o ou sela o loʻo i ai ou genes. O kenera o ni vaega o DNA na faʻasolo mai i lou tina ma lou tama. Latou te aveina faʻamatalaga e iloa ai ou uiga uiga ese, pei o le maualuga ma le lanu o mata.

E masani ona maua e tagata le 46 chromosome, vaevaeina i paga e 23, i potu taʻitasi. O se tasi o paga uma o chromosome e sau mai lou tina, ma le isi paga e sau mai lou tama.

BCR-ABL o se fesuiaʻiga e faia e le tuʻufaʻatasia o lua genes, lauiloa o BCR ma ABL. O isi taimi e taʻua o le fusion gen.

• O le BCR gene e masani ona i luga ole chromosome numera 22.
• Ole kenera ole ABL e masani ona maua ile chromosome numera 9.
• E tupu le suiga o le BCR-ABL pe a malepe vaega o BCR ma ABL genes ma fesuiaʻi nofoaga.
• O le suiga e faʻaalia luga o le chromosome 22, lea na faʻapipiʻi ai e le vaega o le chromosome 9 ia lava.
• O le mutated chromosome 22 ua taʻua o le Philadelphia chromosome aua o le 'aʻai na faʻatoa maua ai e le au suʻesuʻe.
• Ole vaega ole BCR-ABL e leʻo le ituaiga suiga e maua mai i ou matua. O se ituaiga o mutimuti mutation, o lona uiga e te leʻi fananau mai ma ia. E te mauaina mulimuli ane i le olaga.

O le BCR-ABL gene faʻaalia i tagata mamaʻi ma nisi ituaiga o leukemia, o le kanesa o le ponaivi ponaivi ma papaʻe sela toto. BCR-ABL e maua i le toeititi o tagata mamaʻi uma ma le ituaiga o leukemia taʻua o le myeloid leukemia masani (CML). O le isi igoa mo CML e masani myelogenous kanesa o le toto O igoa uma e lua e faʻasino i le faʻamaʻi lava e tasi.

O le BCR-ABL gaʻo o loʻo maua foi i nisi tagata mamaʻi ma se ituaiga o matuitui lymphoblastic leukemia (UMA) ma seasea i tagata mamaʻi ma matuitui myelogenous leukemia (AML).

Nisi vailaʻau kanesa e sili ona aoga ile togafitia o leukemia tagata mamaʻi ma le BCR-ABL gene mutation. O nei vailaʻau e i ai foʻi ni faʻafitauli laiti nai lo isi togafitiga o le kanesa. O vailaʻau lava e tasi e le aoga i le togafitia o ituaiga kanesa o leukemia poʻo isi kanesa.

Isi igoa: BCR-ABL1, BCR-ABL1 fusion, Philadelphia chromosome

O le a le mea e faʻaaoga ai?

O le suʻega BCR-ABL e masani ona faʻaaoga e suʻesuʻe ai pe faʻaleaogaina ai le myemiaid leukemia (CML) poʻo se ituaiga o leukemia ogaoga o le lymphoblastic (ALL) e taʻua o le Ph-positive ALL. Ph-positive o lona uiga o le Philadelphia chromosome na maua. E le faʻaaogaina le suʻega e suʻesuʻe ai isi ituaiga o kanesa.

E mafai foi ona faʻaaoga le suʻega e:

• Vaʻai pe aoga le togafitiga o le kanesa.
• Vaʻai pe o se tagata maʻi ua atiaʻe le teteʻe atu i nisi togafitiga. O lona uiga o se togafitiga na aoga e le toe aoga.

Aisea ou te manaʻomia ai se BCR-ABL ituaiga faʻamaoniga?

Oe ono manaʻomia se suʻega BCR-ABL pe a iai ni faʻailoga o le myeloid leukemia masani (CML) poʻo le Ph-positive lymphoblastic leukemia (ALL). E aofia ai:

• Le lavava
• Fiva
• Paʻu pauna
• Afu i le po (ova le afu ao moe)
• Paʻu soʻoga poʻo le ponaivi

Nisi tagata e maua le CML poʻo le Ph-positive UMA e leai ni faʻailoga, pe faʻafuaseʻi lava ni faʻailoga, aemaise lava ile amataga o faʻamaʻi. E ono faʻatonuina la e lau tausi soifua maloloina lenei suʻega pe a fai o se aofaʻiga o le toto poʻo isi suʻega toto na faʻaalia ai iʻuga e le masani E tatau foʻi ona e faʻailoa i lau tautua pe a iai ni faʻailoga e te popole ai. CML ma Ph-positive UMA e faigofie ona togafitia pe a vave maua.

Oe ono manaʻomia foi lenei suʻega pe a fai o loʻo togafitia oe mo CML poʻo le Ph-positive UMA. E mafai ona fesoasoani le suʻega i lau tautua pe faʻapea o aoga ou togafitiga.

Ole a le mea e tupu ile taimi ole suʻega ole gaʻo ole BCR-ABL?

O le faʻataʻitaʻiga BCR-ABL e masani lava o le suʻega toto poʻo se faʻataʻitaʻiga e taʻua o le ponaivi o le ponaivi faʻanana ma le biopsy.

Afai o fai sau suʻega ile toto, o se polofesa mo le soifua maloloina o le a ave se toto faʻataʻitaʻiga mai se uaua i lou lima, faʻaaoga ai se tamaʻi nila. A maeʻa ona tuʻu i totonu le nila, o le a faʻaputuputuina se vaega laʻititi o le toto i totonu o se faʻamaoniga poʻo se ipu. Atonu e te lagonaina sina tiga pe a alu le nila i totonu pe fafo. Lenei masani ona alu ifo i lalo o le lima minute.

Afai o loʻo e mauaina se ponaivi faʻanaunauga manaʻo ma biopsy, lau faʻagasologa e ono aofia ai laʻasaga nei:

• Oe o le a taoto i lou itu po o lou manava, faalagolago i le ivi o le a faaaoga mo suʻega. Ole tele o ponaivi suʻega e suʻe mai le ponaivi ponaivi.
• O lou tino o le a ufiufi i ie, ina ia na o le eria o loʻo faʻataʻitaʻia le nofoaga o loʻo faʻaalia.
• O le 'upega tafaʻilagi o le a faʻamamaina i se vailaʻau.
• Oe o le a maua se tui o se numbing fofo. E tiga.
• O le taimi lava e le aoga le eria, o le tausi soifua maloloina o le a ave le faʻataʻitaʻiga. E tatau ona e taoto pea i taimi o suʻega.
  • Mo le manaʻomia o ponaivi ponaivi, lea e masani ona faia muamua, o le tausi soifua maloloina o le a tuʻuina se nila i le ponaivi ma toso ese ponaivi suo ponaivi ma sela. Atonu e te lagonaina se tiga maai ae puʻupuʻu pe a tuʻu i totonu le nila.
  • Mo le biopsy o le ponaivi o le ponaivi, o le a faʻaogaina e le tausi soifua maloloina se mea faigaluega faʻapitoa e mimilo i totonu o le ponaivi e aveese se faʻataʻitaʻiga o ponaivi ponaivi ponaivi. Atonu e te lagonaina se faʻamalosi i luga o le upega tafailagi a o faia le faʻataʻitaʻiga.
• E tusa ma le 10 minute le umi e fai ai faʻataʻitaʻiga uma e lua.
• A maeʻa le suʻega, o le a ufiufi e le tausi soifua maloloina le 'upega tafaʻilagi ma se fusi.
• Fuafua e ave se tasi e momoli oe i le fale, talu ai atonu o le a tuʻuina atu ia te oe se faʻamalieina ae e leʻi faia suʻega, lea e ono mafua ai ona e fia moe.

Mata e tatau ona ou faia se mea e sauniuni ai mo le suʻega?

E masani ona e le manaʻomia ni sauniuniga faʻapitoa mo le toto poʻo le ponaivi suʻega.

E i ai ni lamatiaga i le suʻega?

E laʻititi lava le aʻafia ile faia ole suʻega ile toto. E i ai sina tiga poʻo se tiga i le mea na tuu ai le nila, ae o le tele o faʻailoga e vave ona alu ese.

A maeʻa le suʻega o ponaivi, e te lagona le maʻaʻa pe tiga foi i le nofoaga na tui ai. Lenei masani lava ona alu i ni nai aso. Atonu e fautuaina e lau fomaʻi lau fomaʻi pe e te faʻamamaina le tiga e fesoasoani.

O le a le uiga o faʻaiuga?

Afai o faʻaiuga ua faʻaalia ai o loʻo ia oe le BCR-ABL gaʻo, faʻapea foʻi ma le le masani ai o sela papaʻe o le toto, e ono aʻafia ai oe ile maʻi ole myeloid leukemia (CML) poʻo le Ph-positive, o le toto o le lymphoblastic leukemia (ALL).

Afai o loʻo togafitia oe mo CML poʻo le Ph-positive UMA, o au iʻuga ono faʻaalia:

• Ole aofaʻi ole BCR-ABL i lou toto poʻo le ponaivi o loʻo faʻateleina. Atonu o lona uiga o lau togafitiga e le galue ma / pe ua e teteʻe i se togafitiga faʻapitoa.
• O le aofaʻi o BCR-ABL i lou toto poʻo ponaivi ponaivi ua faʻaitiitia. Atonu o lona uiga o loʻo galue ou togafitiga.
• O le aofaʻi o BCR-ABL i lou toto poʻo ponaivi ponaivi e leʻi faʻateleina pe paʻu. Atonu o lona uiga e mausali lou faʻamaʻi.

A iai ni au fesili e uiga i au iʻuga, talanoa i lau fomaʻi.

Aʻoaʻo atili e uiga i suʻesuʻega falesuesue, vaitau o faʻasino, ma malamalamaaga i iʻuga

E i ai seisi mea e tatau ona ou iloa e uiga i le BCR-ABL gaʻoa keni?

Togafitiga mo le myeloid leukemia masani (CML) ma le Ph-positive, lega o le lymphoblastic leukemia (ALL) ua manuia i tagata mamaʻi ma nei ituaiga o leukemia. E taua le vaʻaia o lau soifua maloloina i taimi uma e mautinoa ai o loʻo tumau pea ona lelei ou togafitiga. A faʻapea e te teteʻe atu i togafitiga, e ono fautuaina e lau kamupani isi ituaiga o kanesa togafitiga.

Faʻamatalaga

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O faʻamatalaga i luga o lenei 'upega tafaʻilagi e le tatau ona faʻaaogaina e fai ma sui o fomaʻi faʻapitoa togafitiga poʻo fautuaga. Faʻafesoʻotaʻi le au tausi soifua pe a iai ni au fesili e uiga i lou soifua maloloina.