Calcinosis Cutis

Anotusi

• Ituaiga o calcinosis cutis
• Faʻailoga o le calcinosis cutis
• Mafuaʻaga o kalisiisimoti cutis
• Faʻailoga o le Dystrophic
• Faʻailogaina metastatic
• Faʻailogaina Idiopathic
• Faʻailoga ole Iatrogenic
• Calciphylaxis
• Faʻatasi ma le scleroderma
• Suʻesuʻega o calculus ole kanesa
• Togafitiga o le kanesaisisi cutis
• Fualaʻau
• Taotoga
• Isi togafitiga
• Vaaiga mo le kalisiisimoti cutis

Vaaiga aoao

Calcinosis cutis o le faʻaputuputuga o tioata masima masima i lou paʻu. O le calcium teuina o ni maʻa faigata e le faʻavaivaia. E eseese foliga ma le lapoʻa o manua.

O lenei o se tulaga seasea e tele mafuaʻaga eseese. O nei e amata mai siama ma manuʻa i faamaʻi sisitema pei o le faaletonu fatugaʻo.

E masani ona leai ni faʻailoga ile tele ole kalisiisiki cutis. Ae i nisi tulaga, e mafai ona matua tiga. O loʻo avanoa togafitiga, e iai ma taotoga, peitaʻi e toe tupu foʻi le papala o le kalama.

Ituaiga o calcinosis cutis

E lima subtypes o calcinosis cutis:

• Faʻailoga o le Dystrophic. Lenei o le sili ona taatele ituaiga o calcinosis. E tupu i le mea ua faʻaleagaina pe mumu le paʻu. E le aofia ai le le masani ai tulaga o le calcium poʻo le phosphore i le tino.
• Faʻailogaina metastatic. E tupu lea i tagata e maualuga le maualuga o le maualuga o le calcium ma le phosphorus.
• Faʻailogaina Idiopathic. E leai se mafuaʻaga ua aliali mai ai i lenei ituaiga o faʻatauina o le calcinosis cutis. E masani ona tupu i le tasi vaega o le tino.
• Faʻailoga ole Iatrogenic. Lenei ituaiga o calcinosis cutis faʻaiuga mai se togafitiga togafitiga poʻo togafitiga, masani lava faʻafuaseʻi. Mo se faʻataʻitaʻiga, o pepe faatoa fananau mai e mafai ona i ai le iatrogenic fuafua i luga o le mulivae, mafua mai mulivae laʻau e ave le toto.
• Calciphylaxis. O lenei ituaiga seasea ma ogaoga ituaiga o kalisioti cutis e masani ona tupu i tagata e le lelei fatugaʻo, na maua se fatugaʻo tui, pe o loʻo faʻataʻamilomiloina i le toto. E afaina ai alatoto toto i le paʻu poʻo le vaega lololo.Kalisioma ma phosphate tulaga i le tino e le masani ai.

Faʻailoga o le calcinosis cutis

O le vaʻaiga ma le nofoaga o le faʻatatauina o le calcinosis cutis e faʻamoemoe i le mafuaʻaga autu. O leona e masani lava faigata, papaʻe-samasama paʻu patupatu i luga o le paʻu luga. Latou amata lemu ma eseese i le tele.

O lesi atonu e leai ni faʻailoga, pe atonu e ogaoga, tiga, pe faʻapupuʻu se mea paʻepaʻe. I ni tulaga e seasea tupu, o se papala e ono lamatia ai le ola.

Nei o vaega e masani ona aliali ai leona i laiti taʻitasi o subtypes o le kalisiisimoti tipi:

• Faʻailoga o le Dystrophic. O patupatu e tupu i le vaega o mea ua faaleagaina. O vaega masani o lima, tulilima, tamailima ma tulivae. Faʻatasi ma lupus, o leona tutupu i lima ma vae, o le papa, ma lalo o le lupus lesions.
• Faʻailogaina metastatic. O faʻamau e maua faʻatasi i tafatafa o soʻoga: tulivae, tulilima, poʻo tauʻau. E mafai foi ona feoaʻi solo totoga i totonu, pei o mama, fatugaʻo, alatoto, poʻo le manava. Lisi e faʻataʻamilo i soʻoga e mafai ona faʻatapulaʻaina le feoaʻi a o faʻamalosia le paʻu.
• Faʻailogaina Idiopathic. Lenei masani lava aafia ai na o le tasi le vaega o le tino. E mafai ona tupu faʻataʻamilo i soʻoga soʻoga, o le ulu, o le ulu, o le susu, o le penis, o le papala, poʻo lima ma vae. I tamaiti atonu o luga o foliga. O papala e mafai ona paʻepaʻe le palapala.
• Faʻailoga ole Iatrogenic. O le faʻamaʻi e aliali mai i le nofoaga o se togafitiga faʻafomaʻi poʻo se togafitiga faʻasolosolo e tuia le paʻu.
• Calciphylaxis. O le paʻu o le paʻu e masani ona i luga o vae poʻo le ogalaau, aemaise lava vaega gaʻo e pei o fatafata, faʻamau, ma le manava. O leona e motimomi foliga ma tiga. E mafai ona avea ma papala e le faʻamaloloina, pe mafai foi ona latou tupu aʻe le gangrene. O faʻamaʻi atonu e o mai faʻatasi ma isi faʻailoga, pei o le lelava ma vaivaiga.

Mafuaʻaga o kalisiisimoti cutis

Calcinosis cutis e seasea tupu ae e tele ona mafuaʻaga, faʻamoemoe i le subtype:

Faʻailoga o le Dystrophic

I se tulaga aoao, o le faaleagaina o aano o le tino e taitai atu ai i polotini phosphate faamalolo e oti sela lea ona fuafua, fausia masima kalisiu. O le faʻaletonu mea e mafai ona sau mai:

• faʻamaʻi pipisi
• tuma
• fuafua
• fesoʻotaʻiga fesoʻotaʻiga faʻamaʻi pei o lupus, systemic sclerosis, poʻo le dermatomyositis

Faʻailogaina metastatic

A faʻapea e le masani ai le maualuga o le calcium phosphate ole tino, na te gaosia ni masima masima e fai ma nodules ile paʻu. Mafuaʻaga o le le masani ai tulaga o kalisiu ma phosphate o:

• faaletonu fatugaʻo faaumiumi (o le sili ona taatele mafuaʻaga)
• tele vitamini D
• hyperparathyroidism (o se faʻalauteleina parathyroid gland soona faʻateleina thyroid homone)
• sarcoidosis (kulupu o sela mumu faʻatupuina i mama, lymph nodes, paʻu, ma isi vaega o le tino)
• susu-alkali syndrome (tele kalisiu mai meaai poʻo antacids)
• ponaivi ponaivi, pei o Paget's faamaʻi

Faʻailogaina Idiopathic

E le pei o ituaiga muamua e lua o le calcinosis cutis, o le idiopathic calculification e tupu e aunoa ma le afaina ai o aano o le tino ma leai ni tulaga le masani ai o le calcium poʻo le phosphore. Idiopathic o lona uiga "leai se mafuaaga iloa." E tolu ituaiga:

• aiga nodules, e masani ona aliali mai i le soifua maloloina talavou poʻo tamaiti laiti
• subepidermal nodules, lea e aliali mai i lalo ifo o le paʻu
• nodules i luga o le scrotum

Faʻailoga ole Iatrogenic

O le mafuaʻaga o le faʻavasegaina o le iatrogenic o se auala faʻafomaʻi e le faʻafuaseʻi ona tau atu i le calcium salt deposit o se itu o le itu. O le faiga mo lenei le iloa. O nisi o taualumaga e aofia ai:

• Faʻatonutonuina o faʻafitauli o loʻo iai le calcium ma le phosphate
• umi le faʻafesoʻotaʻiga ma saturated calcium chloride electrode faapipii i le taimi o le electroencephalograph poʻo le electromyograph
• intravenous calcium gluconate, calcium chloride, ma para-aminosalicylic acid i le fatafata vaivai
• mulivae faʻamau i pepe fou

Calciphylaxis

O le mafuaʻaga o le calciphylaxis o loʻo tumau pea le mautinoa. E seasea lava, e ui o nisi o mea fesoʻotaʻi e taatele:

• faaletonu fatugaʻo faaumiumi
• puta lapoʻa
• maʻi suka
• hyperparathyroidism

Faʻatasi ma le scleroderma

O le Calcinosis cutis e masani ona tupu faʻatasi ma le systemler sclerosis (scleroderma). E maua faʻapitoa lava ile faʻatapulaʻa o lenei faʻamaʻi, e taʻua ole faʻatapulaʻaina ole siʻi tino (CREST).

O se faatatau oi latou ei ai faʻamaʻi CREST o le a atiaʻe faʻasologa o meaola peʻa maeʻa.

E masani ona aliali mai manua i tamatamailima ma tulilima ma e ono gagala ma faʻasusu se mea paʻepaʻe mafiafia.

Suʻesuʻega o calculus ole kanesa

Fuafua le ituaiga o calculus o loʻo ia te oe e taua tele i le filifiliaina o togafitiga talafeagai. O le a suʻea oe e lau fomaʻi ma ave lau talaʻaga faʻafomaʻi ma fesili ia te oe i fesili e uiga i ou faʻailoga.

E ono faʻatonu e le fomaʻi ni suʻesuʻega ile fale suesue e suʻesuʻe ai le mafuaʻaga o lau kanesaisisisi.

• suʻesuʻe le toto e iloa ai pe faʻapea e maualuga le maualuga o lou calcium ma le phosphate maualuga, e suʻe ai faʻailoga mo le lupus ma ono mafai ona faʻamaʻi, ma ia teteʻe ile le masani ai ile parathyroid ma le vaitamini D.
• metabolic suʻega e faʻateʻa ai faʻafitauli o fatugaʻo
• X-ray, CT scan, poʻo ponaivi suʻega (scintigraphy) e vaʻai i le lautele o le faʻailogaina
• biopsy o faʻamaʻi
• isi faʻapitoa faʻapitoa suʻesuʻega e siaki ai dermatomyositis (o se faʻamaʻi mumu) ma susu-alkali syndrome

O se fou tekonolosi i lalo o atinaʻe e fesoasoani faʻamaoniga o alualu i luma vibrator spectroscopy. O lenei metotia faʻataʻitaʻi e faʻaaogaina Fourier suia infrared (FT-IR) poʻo le Raman spectroscopic analysis. E vave faʻailoaina le vailaʻau tuʻufaʻatasia o le kanesa faʻasologa o laʻau. E mafai foi ona valoʻia le alualu i luma o faʻamaʻi.

Togafitiga o le kanesaisisi cutis

Togafitiga mo calcinosis cutis faalagolago i le mafuaʻaga o faʻamaʻi pe mafuaʻaga.

Fualaʻau

Eseese vailaʻau mafai ona faʻataʻitaʻia e togafitia ai faʻamaʻi, peitaʻi o lo latou alualu i luma ua vaʻaia.

Mo laʻau laʻititi, vailaʻau e aofia ai:

• warfarin
• ceftriaxone
• intravenous immunoglobulin (IVIG)

Mo lapoa lapoʻa, vailaʻau e aofia ai:

• diltiazem
• bisphosphonates
• probenecid
• alumini hydroxide

O le suʻesuʻega i le 2003 na lipotia mai ai o le maualalo o le vailaʻau o le antibiotic minocycline na aoga e faʻamalieina ai le tiga ma le tele o faʻamaʻi i tagata e maua i le CREST syndrome. E mafai foi ona aoga le sodium thiosulfate.

Taotoga

Afai e tiga lou manuʻa, faʻamaʻi soo, pe faʻaletonu lou gaioiga, e ono fautuaina e lau fomaʻi se taotoga. Ae o leona ono mafai ona toe tupu pe a uma taotoga. E fautuaina le amataina o taotoga ile tamaʻi vaega o le papala.

Isi togafitiga

O se togafitiga fou ua fuafuaina o le hematopoietic stem cell transplantation (HSCT), lea e sui ai sela o le toto o se tagata. Ua faʻaaogaina lea e togafitia ai faʻamaʻi o le autoimmune.

Leisa togafitiga ma faʻateʻia galu lithotripsy (o se ultrasound togafitiga faʻaogaina e talepe fatugaʻo fatugaʻo) o togafitiga foʻi.

Vaaiga mo le kalisiisimoti cutis

O le vaʻaiga mo calculusisini cutis e faʻamoemoe i lona faʻamaʻi poʻo le mafuaʻaga, ma le ogaoga o ou faʻamaʻa. Togafitiga o loʻo i ai nei e mafai ona fesoasoani, ma fou togafitiga ua atiaʻe. Talanoa i lau fomaʻi pe faʻafefea ona mapu ou faʻailoga ma togafitia le aʻa o le faʻafitauli.