HER2 (Kanesa o le susu) Suʻega

Anotusi

• O le a le suʻega ole kanesa ole susu ole HER2?
• O le a le mea e faʻaaoga ai?
• Aisea oute manaʻomia ai le suʻega ole kanesa ole susu HER2?
• Ole a le mea e tupu ile suʻega ole HER2 ile kanesa ole susu?
• Mata e tatau ona ou faia se mea e sauniuni ai mo le suʻega?
• E i ai ni lamatiaga i le suʻega?
• O le a le uiga o faʻaiuga?
• E i ai se isi mea e tatau ona ou iloa e uiga i le HER2 susu kanesa suʻega?
• Faʻamatalaga

O le a le suʻega ole kanesa ole susu ole HER2?

O le HER2 e tu mo le tagata epidermal tuputupu aʻe vaega taliaina 2. O se kenera e faia ai se polotini maua i luga o uma uma sela sela. E aʻafia i le tuputupu aʻe o sela.

O sene o vaega taua ia o lona tupuʻaga, faʻasolo mai i lou tina ma lou tama. I nisi kanesa, aemaise lava kanesa o le susu, o le HER2 gene mutates (suiga) ma faia faʻaopoopo kopi o le kenera. A tupu lenei mea, o le HER2 gene faia tele HER2 porotini, mafua ai sela e vaelua ma tupu vave tele.

O kanesa ma maualuga maualuga o le HER2 protein e taʻua o le HER2-positive. O kanesa e maualalo le maualuga o le polotini e taʻua ole HER2-leaga. E tusa ma le 20 pasene o kanesa o le susu e HER2-lelei.

HER2 faʻataʻitaʻiga vaʻai i se faʻataʻitaʻiga o tuma sela. O auala taatele e faʻataʻitaʻi ai le tino o le:

• Immunohistochemistry (IHC) suʻesuʻeina le fuaina o le HER2 protein i luga o sela
• Fluorescence in situ hybridization (FISH) suʻega vaʻai mo sili kopi o le HER2 gene

O ituaiga uma o suʻega e mafai ona iloa ai pe ua maua oe ile HER2-positive cancer. Togafitiga e faʻapitoa faʻatatau ile HER2-positive kanesa ole susu e mafai ona matua aoga.

Isi igoa: tagata epidermal tuputupu aʻe vaega resitara 2, ERBB2 faʻateleina, HER2 ova o faʻamatalaga, HER2 / neu suʻega

O le a le mea e faʻaaoga ai?

Ole suʻega ole HER2 e tele na faʻaaoga e suʻe ai pe o le kanesa ole HER2-lelei. E faʻaaoga foʻi i nisi taimi e vaʻai ai pe o tali le kanesa i togafitiga pe ua toe foʻi mai le kanesa ina ua maeʻa togafitiga.

Aisea oute manaʻomia ai le suʻega ole kanesa ole susu HER2?

Afai na faʻamaonia oe i le kanesa o le susu, oe ono manaʻomia lenei suʻega e suʻe ai pe o lou kanesa e HER2-lelei pe HER2-le lelei. Afai ua uma ona togafitia oe mo le HER2-positive kanesa o le susu, oe ono manaʻomia lenei faʻataʻitaʻiga e:

• Saili pe aoga ou togafitiga. Tulaga masani ole HER2 atonu o lona uiga o loʻo e tali atu i togafitiga. Maualuga tulaga ono uiga o le togafitiga e le ola.
• Saili pe na toe foʻi mai le kanesa ina ua maeʻa togafitiga.

Ole a le mea e tupu ile suʻega ole HER2 ile kanesa ole susu?

Ole tele ole suʻega ole HER2 e aofia ai le ave ole faʻataʻitaʻiga ole tino ole tumo ile faiga ua taʻua ole biopsy E tolu ituaiga autu ole faʻasologa o le biopsy:

• Biopsy moomoo manaʻomia lelei lea e faʻaaoga ai se nila matua manifinifi e aveʻese ai se faʻataʻitaʻiga o susu sela poʻo suavai
• Biopsy nila nila, lea e faʻaaoga ai se nila tele e aveʻese ai se faʻataʻitaʻiga
• Biopsy taotoga, lea aveese se faʻataʻitaʻiga i se laʻititi, outpatient gaioiga

Manatu lelei moʻa ma biopsies autu nila masani ona aofia ai laʻasaga nei:

• O le a e taoto i ou tafatafa pe nofo i luga o le laulau suʻega.
• O le tausi soifua maloloina o le a faʻamamaina le nofoaga o le biopsy ma tuiina i se vailaʻau faʻapitoa ina ia oe o le a le lagonaina se tiga i le taimi o le gaioiga.
• O le taimi lava e leai se mea o le eria, o le a tuʻuina atu e le kamupani tuʻuina atu a lelei nila manaʻomia poʻo nila biopsy autu i le biopsy nofoaga ma aveʻese se faʻataʻitaʻiga o aano o le tino poʻo suavai.
• Atonu e te lagonaina sina faʻamalosiʻau pe a toʻesea le faʻataʻitaʻi.
• O le a faʻamalosia le faʻamalosiina i le nofoaga o le biopsy seʻia maeʻa le tafetoto.
• O lau tautua o le a tuʻuina se mea faʻamoe i le nofoaga o le biopsy.

I se taotoga biopsy, o le fomai tipitipi o le a faia sina tamaʻi tipi i lou paʻu e aveʻese uma poʻo se vaega o le fatafata susu. O se taotoga biopsy e faia i nisi taimi pe a fai e le mafai ona aʻapa le lump i se nila biopsy. O taotoga faʻapitoa e masani ona aofia ai laʻasaga nei.

• O le a e taʻoto i luga o le laulau faʻagaioia. E mafai ona tuʻuina se IV (laina faʻatumu) i lou lima poʻo lou lima.
• Atonu e avatua ia te oe vailaʻau, e taʻu ole vailaʻau, e fesoasoani e te malolo ai.
• Oe o le a tuʻuina atu i le lotoifale poʻo le lautele vai faagase faʻapea e te le o lagonaina tiga i le taimi o le gaioiga.
  • Mo vai faagase i le lotoifale, o le a tuiina e le tausi soifua maloloina le nofoaga o le biopsy ma vailaʻau e faʻanofo ai le eria.
  • Mo lautele vai faagase, o se faʻapitoa valaʻauina se vailaʻau faʻapitoa o le a avatua ia te oe vailaʻau o lea o le a e matapogia ai i le taimi o le gaioiga.
• O le taimi lava e leai se aoga o le vaega o le biopsy pe e te leʻo iloaina foi, o le a faia e le fomai tipitipi sina tipi i totonu o le fatafata ma aveʻese vaega poʻo se atoa o se paluga. E mafai foʻi ona aveʻese isi mea i autafa o le pu.
• O le tipi i lou paʻu o le a tapunia ma suʻi poʻo ni fasi pepa faʻapipiʻi.

O le ituaiga o biopsy o loʻo ia te oe o le a faʻamoemoeina i mea eseese, e aofia ai le tele ma le nofoaga o le tumo. O le HER2 e mafai foi ona fuaina ile suʻega ole toto, ae e leʻi faʻamaonia le aoga ole suʻega ole toto mo le HER2 mo le tele o tagata mamaʻi. Ma e le masani ona fautuaina.

A maeʻa ona faʻaogaina lau vaega, o le a tofotofoina i se tasi o auala e lua:

• Ole fua ole polotini ole HER2 ole a fuaina.
• O le faʻataʻitaʻiga o le a suʻesuʻeina mo nisi kopi o le HER2 gene.

Mata e tatau ona ou faia se mea e sauniuni ai mo le suʻega?

E te le manaʻomia ni sauniuniga faʻapitoa pe a fai o loʻo e mauaina se vai faagase i le lotoifale (faʻamamaina o le nofoaga o le biopsy). Afai o loʻo e mauaina le faʻateʻa lautele, e ono manaʻomia ona e anapogi (aua le 'ai pe inu) mo ni nai itula ae e te leʻi faia se taʻotoga. O lau fomai tipitipi o le a avatua ia te oe nisi faʻatonuga faʻapitoa. Faʻapea foi, afai o loʻo e mauaina se vailaʻau faʻasoesa poʻo le lautele, ia mautinoa e teuteuina seisi e aveina oe i le fale. Atonu e te maʻa ma le mautonu pe a maeʻa ona e ala mai i le faiga.

E i ai ni lamatiaga i le suʻega?

E i ai sina manuʻa poʻo se toto i le nofoaga na fausia ai le biopsy. O nisi taimi e afaina ai le 'upega tafaʻilagi. Afai e tupu lena mea, o le a togafitia oe ma vailaʻau oona. O se taotoga biopsy e ono mafua ai nisi tiga ma le le mautonu. Atonu e fautuaina e lau fomaʻi ni talavai e fesoasoani ia te oe ia maua se lagona lelei.

E laʻititi lava le aʻafia ile faia ole suʻega ile toto. E i ai sina tiga poʻo se tiga i le mea na tuu ai le nila, ae o le tele o faʻailoga e vave ona alu ese.

O le a le uiga o faʻaiuga?

Afai o HER2 protein maualuga e maualuga atu nai lo le masani ai pe tele kopi o le HER2 gene o maua, atonu o lona uiga o loʻo maua oe ile HER2-positive cancer. Afai o au faʻaiuga faʻaalia masani masani o HER2 porotini poʻo le numera masani HER2 genes, oe ono i ai HER2-le lelei kanesa.

Afai o au iʻuga e leʻi manino lelei pe le lelei, atonu o le a toe faʻataʻitaʻia oe, a le o le faʻaaogaina o se faʻavae eseese o le patu poʻo le faʻaaogaina o se isi metotia suʻega. O le tele o taimi, IHC (suʻega mo le HER2 protein) e faia muamua, sosoʻo ai ma le FISH (suʻesuʻeina mo isi kopi o le gafa). O le suʻesuʻega a le IHC e laʻititi ifo lona tau ma maua ai ni taunuʻuga vave nai lo o le FISH. Ae o le toʻatele o fomaʻi faʻapitoa e manatu o le FISH tofotofoga e sili atu le saʻo.

Togafitiga mo le HER2-positive cancer o le susu e mafai ona matua faʻaitiitia ai le kanesa o le kanesa, ma ni nai aʻafiaga. O nei togafitiga e le aoga i HER2-le lelei kanesa.

Afai o loʻo togafitia oe mo le HER2-positive cancer, o faʻaiuga masani atonu o lona uiga o loʻo e tali atu i togafitiga. Iʻuga e faʻaalia maualuga atu nai lo le aofaʻi masani atonu o lona uiga e leʻo ola ou togafitiga, pe ua toe foʻi mai le kanesa ina ua maeʻa togafitiga.

Aʻoaʻo atili e uiga i suʻesuʻega falesuesue, vaitau o faʻasino, ma malamalamaaga i iʻuga

E i ai se isi mea e tatau ona ou iloa e uiga i le HER2 susu kanesa suʻega?

E ui e sili atu ona taatele i fafine, o le kanesa o le susu, e aofia ai ma le kanesa o le susu o le HER2-positive, e mafai foi ona aʻafia ai aliʻi. Afai ua maua se tamaloa i le kanesa o le susu, e mafai ona fautuaina le suʻeina o le HER2.

I se faʻaopopoga, aliʻi ma fafine e ono manaʻomia le faʻataʻitaʻiga HER2 pe a fai na maua i latou i ni kanesa o le manava ma le esophagus. O nei kanesa i nisi taimi e i ai maualuga maualuga o le HER2 porotini ma ono tali lelei i HER2-lelei kanesa togafitiga.

Faʻamatalaga

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O faʻamatalaga i luga o lenei 'upega tafaʻilagi e le tatau ona faʻaaogaina e fai ma sui o fomaʻi faʻapitoa togafitiga poʻo fautuaga. Faʻafesoʻotaʻi le au tausi soifua pe a iai ni au fesili e uiga i lou soifua maloloina.