Tautala ma fofo Injectable MS Togafitiga: O le a le Eseesega?

Anotusi

• Filifilia o se vailaʻau MS
• O vailaʻau e mafai ona tuiina oe lava
• Avonex (interferon beta-1a)
• Betaseron (interferon beta-1b)
• Copaxone (glatiramer acetate)
• Extavia (interferon beta-1b)
• Glatopa (glatiramer acetate)
• Plegridy (pegylated interferon beta-1a)
• Rebif (interferon beta-1a)
• Vailaau e tui totonu
• Lemtrada (alemtuzumab)
• Mitoxantrone hydrochloride
• Ocrevus (ocrelizumab)
• Tysabri (natalizumab)
• Vailaau tautala
• Aubagio (teriflunomide)
• Gilenya (tamailima)
• Tecfidera (dimethyl fumarate)
• Le aveeseina

Vaaiga aoao

Multiple sclerosis (MS) o se faʻamaʻi autoimmune lea e osofaʻia e le tino o le tino le pupuni o myelin o ou neula. I le iuga, o lenei mafua ai le faʻaleagaina o neula latou lava.

E leai se togafiti mo le MS, ae o togafitiga e mafai ona fesoasoani i le faʻatonutonuina o faʻailoga ma tuai ai le alualu i luma o le faʻamaʻi.

Faamaʻi-fesuiaʻi togafitiga (DMTs) ua fuafuaina e faifai lemu le alualu i luma umi o le faamai, faaitiitia relapses, ma puipuia fou faaleagaina mai tupu.

DMTs mafai ona faia tuʻu fofoga pe tui. O tui e mafai ona faatigaina e le tagata ia lava i le fale pe tuʻuina atu e avea o ni faʻalavelave oʻona i totonu o se nofoaga faʻafomaʻi.

O vailaʻau tuʻufua ma tuiina e iai faʻamanuiaga ma aʻafiaga e ono aliali mai. Toatele e omai ma faʻapitoa lapataiga mai le Food and Drug Administration (FDA).

Filifilia o se vailaʻau MS

E tele mea e tatau ona mafaufau i ai pe a filifili i le va o gutu ma tui togafitiga. Mo se faʻataʻitaʻiga, o vailaʻau tuufofoga e inu i aso uma, aʻo le tele o vailaʻau tui e tipi soʻo.

E mafai e lau fomaʻi ona fesoasoani ia te oe e fuaina mea lamatia faʻasaga i penefiti ma filifili le filifiliga pito sili ona lelei mo oe.

E taua lau mea e te manaʻo ai ile filifiliga o togafitiga togafitiga. O mea taua e te manaʻo e mafaufau i ai o:

• aoga le vailaʻau
• ona aʻafiaga
• le tele o tui
• le metotia faʻaaoga e faʻatautaia ai vailaʻau

O vailaʻau e mafai ona tuiina oe lava

O vailaʻau e mafai ona tuiina oe lava e fai ma vaega tele o DMT. O loʻo faʻaaogaina mo le taimi uumi togafitiga o le toe faʻafoʻi-toe aveina MS (RRMS).

O se fomaʻi faʻapitoa o le a toleniina oe i le faiga o tui ina ia mafai ai ona e faʻatautaia lelei lau oe fualaʻau. Tele o nei vailaʻau mafai mafua mumu, fulafula, ma tiga i le tui nofoaga, faʻatasi ai ma isi itu aʻafiaga.

Avonex (interferon beta-1a)

• Penefiti: galue o immune system modulator, ei ai meatotino antiviral
• Faʻasologa masani ma auala: vaiaso, tui intramuscular
• Aafiaga masani masani mafai ona aofia ai: tiga o le ulu, faʻamaʻi pei o le fulū
• Lapataiga aofia ai: ate enzymes ma atoa toto faitauga (CBC) ono manaʻomia le mataʻituina

Betaseron (interferon beta-1b)

• Penefiti: galue o immune system modulator, ei ai meatotino antiviral
• Faʻasologa masani ma auala: isi aso uma, subcutaneous injection
• Aafiaga masani masani mafai ona aofia ai: fulū-pei faʻailoga, maualalo papaʻe sela toto (WBC) faitau
• Lapataiga aofia ai: ate enzymes ma CBC ono manaʻomia le mataʻituina

Copaxone (glatiramer acetate)

• Penefiti: galue o immune system modulator, poloka poloka i luga o le myelin
• Faʻasologa masani ma auala: aso taʻitasi pe faʻatolu taimi ile vaiaso, tui subcutaneous
• Aafiaga masani masani mafai ona aofia ai: fulufuluaʻi, manava puʻupuʻu, mageso, tiga le fatafata
• Lapataiga aofia ai: tui nofoaga e mafai ona avea ma tumau indent ona gaʻo gaʻo ua faʻatamaia (o se iʻuga, faʻaeteete feʻaveaʻiga o tui nofoaga ua fautuaina)

Extavia (interferon beta-1b)

• Penefiti: galue o immune system modulator, ei ai meatotino antiviral
• Faʻasologa masani ma auala: isi aso uma, subcutaneous injection
• Aafiaga masani masani mafai ona aofia ai: fulū-pei o faʻailoga, ulu
• Lapataiga aofia ai: ate enzymes ma CBC ono manaʻomia le mataʻituina

Glatopa (glatiramer acetate)

• Penefiti: galue o immune system modulator, poloka poloka i luga o le myelin
• Faʻasologa masani ma auala: aso uma, subcutaneous tui
• Aafiaga masani masani mafai ona aofia ai: mumu, fulafula, tiga i le nofoaga tui
• Lapataiga aofia ai: tui nofoaga e mafai ona avea ma tumau indent ona gaʻo gaʻo ua faʻatamaia (o se iʻuga, faʻaeteete feʻaveaʻiga o tui nofoaga ua fautuaina)

Plegridy (pegylated interferon beta-1a)

• Penefiti: galue o immune system modulator, ei ai meatotino antiviral
• Faʻasologa masani ma auala: taʻi lua vaiaso, tui subcutaneous
• Aafiaga masani masani mafai ona aofia ai: fulū-pei faʻailoga
• Lapataiga aofia ai: ate enzymes ono manaʻomia le mataʻituina

Rebif (interferon beta-1a)

• Penefiti: galue o immune system modulator, ei ai meatotino antiviral
• Faʻasologa masani ma auala: faatolu ile vaiaso, tui subcutaneous
• Aafiaga masani masani mafai ona aofia ai: fulū-pei faʻailoga
• Lapataiga aofia ai: ate enzymes ono manaʻomia le mataʻituina

Vailaau e tui totonu

O le isi ituaiga filifiliga tuiina mo le togafitia o le MS o loʻo tui totonu. Nai lo le ulufale atu i lau polokalama intramuscularly po subcutaneously, infusions alu saʻo i totonu o se uaua.

O infusions tatau ona tuʻuina atu i se nofoaga faʻafomaʻi e se aʻoaʻo faʻapitoa. E le masani ona faʻatautaia ia inumaga.

O faʻamaʻi totoga e mafai ona tupu ai le faʻatupulaia o aʻafiaga o faʻamaʻi e faʻaopoopo i isi aʻafiaga.

Ocrelizumab (Ocrevus) naʻo le pau lea o vailaʻau ua faʻamaonia e le FDA mo tagata e iai muamua le alualu i luma MS (PPMS). Ua faʻamaonia foʻi e togafitia ai le RRMS.

Lemtrada (alemtuzumab)

• Penefiti: taofiofia myelin-faʻaleagaina sela puipuia
• Faʻasologa masani: i aso uma mo aso e lima; tasi le tausaga mulimuli ane, i aso uma mo le tolu aso
• Aafiaga masani masani mafai ona aofia ai: niniva, puaʻi, manava, tiga le ulu, mageso, mageso
• Lapataiga aofia ai: e mafai ona mafua ai kanesa ma idiopathic thrombocytopenic purpura (IPT), o se faʻamaʻi toto

Mitoxantrone hydrochloride

O lenei vailaʻau e avanoa naʻo se vailaʻau lautele.

• Penefiti: galue o immune system modulator ma suppressor
• Faʻasologa masani: taʻitasi i le tolu masina (olaga faʻatapulaʻa o 8 i le 12 infusions sili atu i le lua i le tolu tausaga)
• Aafiaga masani masani mafai ona aofia ai: paʻu lauulu, niniva, amenorea
• Lapataiga aofia ai: e mafai ona afaina ai fatu ma kanesa o le toto; naʻo le talafeagai mo tagata e iai faʻamaʻi ogaoga o le RRMS, talu ai le tele aʻafiaga o aʻafiaga matuia

Ocrevus (ocrelizumab)

• Penefiti: taulaʻi sela B, o WBC ia e faʻaleagaina neura
• Faʻasologa masani: lua vaiaso vavae ese mo muamua lua tui; tai ono masina uma mo tui mulimuli ane
• Aafiaga masani masani mafai ona aofia ai: fulū-pei faʻailoga, faʻamaʻi
• Lapataiga aofia ai: mafai mafua mafua kanesa ma, i le seasea taimi, afaina-ola faʻafitauli tali atu

Tysabri (natalizumab)

• Penefiti: taofia ai adhesion mole mole, e faʻalavelave ai le puipuiga
• Faʻasologa masani: taʻi fa vaiaso
• Aafiaga masani masani mafai ona aofia ai: tiga le ulu, tiga soʻoga, vaivai, faʻanoanoa, tiga le manava
• Lapataiga aofia ai: mafai faʻateleina lamatiaga o le alualu i luma multifocal leukoencephalopathy (PML), o se ono afaina ai faiʻai

Vailaau tautala

A e le faʻamalieina i ni nila, e i ai gutu filifiliga mo le togafitia o le MS. Aveina i aso uma pe faʻalua i aso uma, o vailaʻau tautala e sili ona faigofie e faʻatautaia e oe lava ae manaʻomia oe e tausisi i le masani ona faia.

Aubagio (teriflunomide)

• Penefiti: galue o immune system modulator, taofia le faʻaleagaina o neula
• Faʻasologa masani: aso uma
• Aafiaga masani masani mafai ona aofia ai: tiga le ulu, suia le ate (pei o le faʻatele o le ate poʻo le maualuga o le ate), niniva, leiloa lauulu, faʻaititia le WBC faitau aofaʻi.
• Lapataiga aofia ai: e mafai ona mafua ai le manua o le ate ma faaletonu fanau mai

Gilenya (tamailima)

• Penefiti: poloka T sela mai le tuua o lymph nodes
• Faʻasologa masani: aso uma
• Aafiaga masani masani mafai ona aofia ai: fulū-pei o faʻailoga, maualuga maualuga ate o le ate
• Lapataiga aofia ai: mafai mafua mafua suiga i le toto maualuga, ate galue, ma fatu fatu

Tecfidera (dimethyl fumarate)

• Penefiti: ei ai aneti-afaina meatotino, puipuia neura ma myelin mai le faʻaleagaina
• Faʻasologa masani: faalua i aso uma
• Aafiaga masani masani mafai ona aofia ai: suiga o le gastrointestinal, faʻaititia le WBC count, siitia maualuga enzymes
• Lapataiga aofia ai: e mafai ona mafua ai matuitui faʻaleagaina tali, e aofia ai anaphylaxis

Le aveeseina

O le faʻamoemoe o togafitiga MS o le faʻatonutonuina o faʻailoga, toe faʻatonutonu le toe solia, ma faʻatelegese le alualu i luma umi o le faʻamaʻi.

Injectable MS togafitiga sau i ni foliga se lua: lava-tuiina ma iniseti faʻasologa. Ole tele o tui e le tau manaʻomia e ave soʻo pei o fofoga, e inu i aso uma.

Uma togafitiga MS maua penefiti, itu aʻafiaga, ma lamatiaga. O le mea sili ona taua o lou faia o au togafitiga e pei ona faʻatonuina, tusa lava poʻo le a le togafitiga oe i ai.

A faʻapea e lava aʻafiaga e mafua ai ona e manaʻo e faamisi togafitiga, talanoa i lau fomaʻi. E mafai ona latou fesoasoani ia te oe e filifili le filifiliga pito sili ona lelei mo oe.