Zollinger-Ellison syndrome

O le Zollinger-Ellison syndrome o se tuutuuga e maua ai e le tino le tele o le homone gastrin. Ole tele ole taimi, ole tamaʻi tuma (gastrinoma) ile pancreas poʻo le tamaititi o le manava ole mafuaʻaga lea ole faʻaopopo ole gastrin ile toto.

O le Zollinger-Ellison syndrome e mafua mai i tuma. O nei tuputupu aʻe e masani ona maua i le ulu o le pancreas ma le pito i luga laititi. O tuma ua taʻua o gastrinomas. Maualuga maualuga o gastrin mafua ai le gaosia o le tele oona manava.

Gastrinomas tupu pei o tasi tuma poʻo ni tele tumors. Tasi afa i le lua vaetolu o nofofua gastrinomas o kanesa (leaga) kanesa. O nei tumors e masani ona sosolo atu i le ate ma lata ane lymph nodes.

Tele o tagata e maua ile gastrinomas e tele latou tuma ole vaega ole tulaga ua taʻua ole tele endocrine neoplasia ituaiga I (MEN I). Tumors mafai ona tupu i le pituitary gland (faiʻai) ma parathyroid gland (ua) faʻapea foi ma le pancreas.

Faʻailoga e ono aofia ai:

• Tiga o le manava
• Manava tata
• Tui toto (i nisi taimi)
• Faʻailoga ogaoga o le esophageal reflux (GERD)

O faʻailoga e aofia ai papala i le manava ma laʻau laiti.

O suʻega e aofia ai:

• Suʻega CT scan
• Suʻesuʻega faʻafefiloi kalisiu
• Endoscopic ultrasound
• Togafitiga suʻesuʻe
• Maualuga toto Gastrin
• Oketopaide scan
• Suʻega faʻaosofia o le Secretin

O fualaʻau e faʻaigoaina o le proton pump inhibitors (omeprazole, lansoprazole, ma isi) o loʻo faʻaaogaina e togafitia ai lenei faʻafitauli. O nei vailaʻau faʻaititia gaosia acid e le manava. E fesoasoani lea i papala i le manava ma laʻau laʻau faʻamalolo. O nei vailaʻau faʻapenaina foi tiga manava ma manava tatā.

O taotoga e aveʻese ai se gastrinoma e tasi e mafai ona faia pe a fai e le sosolo le patu i isi totoga. O taotoga ile manava (gastrectomy) e faʻatonutonu ai le gaosia o le acid e seasea manaʻomia.

O le faʻamalologa fua e maualalo, tusa lava pe a maua vave ma aveʻese le tumo. Peitaʻi, e tupu lemu le gastrinomas.Tagata e maua i lenei maʻi ono ola mo le tele o tausaga pe a maeʻa maua le patu. O vailaʻau-taofiofia vailaʻau e galue lelei e faʻatonutonu ai faʻailoga.

Faʻafitauli e ono aofia ai:

• Le mafai ona maua le tumo i le taimi o le taotoga
• Totolo toto po o le pu (perforation) mai papala i le manava poʻo le duodenum
• Matuā manava tatā ma leiloa paʻu
• Faʻasalalau le tumo i isi totoga

Valaʻau lau fomaʻi pe a fai e tiga tele lou manava e le alu ese, ae maise pe a oʻo i le manava tata.

Z-E faʻamaʻi; Gastrinoma

• Laʻau Endocrine

Jensen RT, Norton JA, Oberg K. Neuroendocrine fiva. I totonu: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger ma Fordtran's Gastrointestinal ma le Maʻi o le ate. 10 ed. Filatelefaia, PA: Elsevier Saunders; 2016: mata 33.

Vella A. Gastrointestinal homone ma le manava namu endocrine. I: Melmed S, Polonsky KS, Larsen PR, Kronenberg HM, eds. Williams Tusitusiga o Endocrinology. 13th lomiga. Filatelefia, PA: Elsevier; 2016: mata 38.