Polymyositis - matua

Polymyositis ma dermatomyositis e seasea afaina faʻamaʻi. (O le tulaga ua taʻua o le dermatomyositis pe a aafia ai le paʻu.) O nei maʻi taitai atu ai i maso vaivai, fulafula, agavaivai, ma faaleagaina tino. O vaega ia o se vaega tele o faʻamaʻi e taʻu o myopathies.

Polymyositis e afaina ai maso o le auivi. Ua lauiloa foi ole idiopathic inflammatory myopathy. O le mafuaʻaga tonu e le o iloa, ae atonu e fesoʻotaʻi ma se autoimmune tali poʻo se faʻamaʻi.

Polymyositis mafai ona aʻafia tagata i soʻo se tausaga. E taatele i tagata matutua i le va o le 50 ma le 60 tausaga, ma i tamaiti matutua. E faalua ona aafia fafine nai lo alii. E taatele i Aferika Amerika nai lo tagata papaʻe.

Polymyositis o se faʻamaʻi tino. O lona uiga e afaina ai le tino atoa. Maso vaivai ma agavaivai mafai ona avea ma faʻailoga o polymyositis. O le mageso o se faʻailoga o se fesoʻotaʻiga tulaga, dermatomyositis.

Faʻailoga masani aofia ai:

• Musika vaivaiga i tauau ma suilapalapa. O lenei mea e mafai ona faʻafaigata ai ona siʻi i luga lima i luga o le ulu, tu i luga mai le nofo tulaga, pe aʻea faasitepu.
• Faigata faʻaumatia.
• Tiga maso.
• Faʻafitauli ma le leo (mafua mai i le vaivai faʻaʻi maso).
• Manava le mānava.

Oe ono iai foi:

• Le lavava
• Fiva
• Tiga soʻoga
• Leai o le fiaai
• Ua malo le taeao
• Paʻu pauna
• Paʻu paʻu i tua o tamailima, i mata o mata, poʻo luga o foliga

O suʻega e mafai ona aofia ai:

• Autoimmune antibodies ma mumu faʻataʻitaʻiga
• CPK
• Serum aldolase
• Eletise
• MRI o maso afaina
• Maso biopsy
• Myoglobin i le miaga
• ECG
• Fatafata x-ray ma le CT faʻataʻitaʻi o le pusa
• Suʻesuʻega o le pulmonary function
• Suesuega faʻaumatia Esophageal
• Myositis faʻapitoa ma fesoʻotaʻi autoantibodies

Tagata e iai lenei faʻafitauli e tatau foʻi ona vaʻaia ma le totoʻa mo faʻailoga o le kanesa.

O le togafitiga autu o le faʻaaogaina o vailaʻau e fai ai le corticosteroid. O le fualaʻau o vailaʻau e lemu lemu tapered ese a maso malosi faʻamalosia. E tusa e 4 i le 6 vaiaso le umi. Oe o le a tumau i luga o se maualalo fuala o le corticosteroid vailaʻau mulimuli ane.

O vailaʻau e tineia ai le tino puipuia e mafai ona faʻaaoga e sui ai le vailaʻau. O nei vailaʻau ono aofia ai azathioprine, methotrexate po mycophenolate.

Mo faʻamaʻi e tumau pea le malosi e ui lava i corticosteroids, o loʻo faʻaosoina gamma globulin ua uma ona faʻataʻitaʻia ma faʻafefiloi taunuuga. E mafai foʻi ona faʻaaogaina vailaʻau o le biologic. Rituximab foliga mai o le sili folafola. E taua le faʻamutaina o isi tulaga i tagata e le tali mai i togafitiga. Atonu e manaʻomia le toe faia ose soʻoga maso e fai ai lenei faʻamaoniga.

Afai o le tulaga e fesoʻotaʻi ma se patu, e mafai ona faʻaleleia pe a aveʻesea le tuma.

Tali atu i togafitiga eseese, faʻavae i luga o faʻafitauli. E toʻa 1 i le 5 tagata e ono feoti i totonu o le 5 tausaga talu ona amata le tulaga.

Tele o tagata, aemaise tamaiti, e malolo mai maʻi ma e le manaʻomia togafitiga faifai pea. Mo le toʻatele o tagata matutua, e ui i lea, e manaʻomia fualaʻau puipuia e puipuia ai le faʻamaʻi.

O le vaaiga mo tagata e maua i faʻamaʻi mama i le anti-MDA-5 antibody e matitiva e ui lava i togafitiga o loʻo i ai nei.

I tagata matutua, oti ono mafua mai i:

• Paleni meaai
• Niumonia
• Faʻamalologa manava
• Ogaoga, taimi umi vaivaiga vaivaiga

O mafuaʻaga autu o le oti o le kanesa ma maʻi mama.

Faʻafitauli e ono aofia ai:

• Kalisiu teu i maso afaina, aemaise lava i tamaiti i le faʻamaʻi
• Kanesa
• Maʻi fatu, maʻi mama, poʻo manava faʻafitauli

Valaʻau lau fomaʻi pe a fai o loʻo e maua i faʻamaʻi o lenei faʻamaʻi. Saili togafitiga faʻafuaseʻi pe a fai ua tau le lava lau manava ma faigata faʻa folo.

• Musele pito i luma o maso

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Dalakas MC. Faamaʻi maso maso faamai. N Engl J Med. 2015; 373 (4): 393-394. PMID: 26200989 www.ncbi.nlm.nih.gov/pubmed/26200989.

Greenberg SA. Myopathies mumusu. I totonu: Goldman L, Schafer AI, eds. Faʻafomaʻi Goldman-Cecil. 25th lomiga. Filatelefaia, PA: Elsevier Saunders; 2016: mata 269

Nagaraju K, Gladue HS, Lundberg IE.Faamai faʻamaʻi o maso ma isi myopathies. I totonu: Firestein GS, Budd RC, Gabriel SE, McInnes IB, O'Dell JR, eds. Kelley ma Firestein's Tusitusiga o Rheumatology. 10 ed. Filatelefia, PA: Elsevier; 2017: mata 85.

Yoshida N, Okamoto M, Kaieda S, et al. Faʻalapotopotoga o le anti-aminoacyl-transfer RNA synthetase antibody ma le anti-melanoma 'eseʻese-fesoʻotaʻi genes 5 antibody ma le tali atu faʻafomaʻi o polymyositis / dermatomyositis-fesoʻotaʻi interstitial mama faʻamaʻi. Tagata suʻesuʻe. 2017; 55 (1): 24-32. PMID: 28012490 www.ncbi.nlm.nih.gov/pubmed/28012490.