Nephritis faʻavaʻa

Interstitial nephritis ose faʻamaʻi fatugaʻo le avanoa i le va o le fatuga tubules faʻafuaseʻi (mu). Lenei mafai mafua faʻafitauli i le ala o ou fatugaʻo faʻagaoioi.

Faʻafitauli nephritis faʻavaitaimi ono le tumau (matuitui), pe ono umi-tumau (faaumiumi) ma atili ai ona leaga taimi.

O le matuitui foliga o interstitial nephritis e masani ona mafua mai i itu aʻafiaga o nisi fualaʻau.

O mea nei e mafai ona mafua ai nephritis interstitial:

• Tali Allergic i se vailaʻau (matuitui sela interstitial nephritis).
• O faʻafitauli o le autoimmune, pei o antitubular basement membrane disease, faʻamaʻi o le Kawasaki, Sjögren syndrome, systemic lupus erythematosus, poʻo le granulomatosis ma le polyangiitis.
• Faamaʻi pipisi.
• Faʻaaoga umi o vailaʻau pei o acetaminophen (Tylenol), aspirin, ma nonsteroidal anti-inflammatory vailaʻau (NSAIDs). E taʻua lenei mea o le analgesic nephropathy.
• Aʻafiaga o nisi vailaʻau e pei ole penicillin, ampicillin, methicillin, ma sulfonamide vailaʻau.
• Aafiaga o isi vailaʻau pei o furosemide, thiazide diuretics, omeprazole, triamterene, ma allopurinol.
• Tele tele potasiuma i lou toto.
• Tele tele kalisiu poʻo uric acid i lou toto.

Faʻafitauli nephritis Interstitial mafai mafua agamalu i ogaoga fatugaʻo faʻafitauli, aofia ai matuitui fatugao toilalo. I le tusa o le afa o mataupu, o le a faʻaititia e tagata le siʻitia o le suavai ma isi faʻailoga o le ogaoga o fatugaʻo.

Faʻailoga o lenei tulaga ono aofia ai:

• Toto i le miaga
• Fiva
• Faʻateleina pe faʻaititia foi le malosi o le mimi
• Ua suia le tulaga o le mafaufau (moe, le mautonu, koma)
• Faanoi, puaʻi
• Mageso
• Fula o soʻo se vaega o le tino
• Faʻateleina le mamafa (mai le taofia vai)

E faʻataʻitaʻi e le tausi soifua le suʻega o le tino. E mafai ona faʻaalia:

• E foliga mai e le masani ai le mama poʻo le fatu
• Toto maualuga
• Suavai i le mama (edema pulmonary)

O suʻega masani e aofia ai:

• Kesi toto Arterial
• Toto kemisi
• BUN ma le toto foafoa maualuga
• Faitau atoa le toto
• Biopsy o fatugaʻo
• Ultrasound fatugaʻo
• Urinalysis

Togafitiga faalagolago i le mafuaaga o le faafitauli. Aloese mai vailaʻau e taitai atu ai i lenei tulaga atonu e vave aveese ai auga.

O le faʻatapulaʻa o le masima ma le vai i meaʻai e mafai ona faʻaleleia ai le fulafula ma le toto maualuga. O le faʻatapulaʻaina o polotini i meaʻai e mafai ona fesoasoani e faʻatonutonu le faʻaputuputuina o otaota i le toto (azotemia), lea e mafai ona oʻo atu ai i faʻailoga o le ogaoga o fatugaʻo.

Afai e manaʻomia le dialysis, e masani lava ona manaʻomia mo naʻo sina taimi puʻupuʻu.

Corticosteroids poʻo vailaʻau e teteʻe ai i le mumusu malosi e pei o le cyclophosphamide e mafai ona fesoasoani i nisi taimi.

O le tele o taimi, interstitial nephritis o se le tumau puʻupuʻu. I tulaga seasea, e mafai ona mafua ai faʻaleagaina tumau, e aofia ai taimi uʻamea (tumau) fatugaʻo toilalo.

O le nephritis interstitial matuitui atonu e sili atu le ogaoga ma ono tau atu ai i se taimi uʻumi pe tumau fatugaʻo faʻaleagaina i tagata matutua.

Metabolic acidosis mafai ona tupu aua le mafai e fatugaʻo ona aveʻese lava acid. O le faʻamaʻi mafai ona taitai atu ai i le matuitui po o faaumiumi fatugao toilalo po o le iuga-tulaga fatugaʻo faamaʻi.

Valaʻau lau tautua peʻa iai ni faʻailoga o le interstitial nephritis.

A faʻapea e te maua i le interstitial nephritis, valaʻau lau tautua pe a fai e te maua ni faʻailoga fou, ae maise pe a fai ua e le mataala pe ua faʻaititia lau paʻu.

Tele taimi, e le mafai ona taofia le faʻamaʻi. Aloʻese pe faʻaititia lou faʻaaogaina o vailaʻau e mafua ai lenei tulaga mafai ona fesoasoani faʻaititia lou tulaga lamatia. A manaʻomia, o le a taʻu atu e lau kamupani o a vailaʻau e taofi pe faʻaititia.

Nephritis tubulointerstitial; Neura - faʻatonu; Matuia interstitial (afaina) nephritis

• Anatomia fatugaʻo

Neilson EG. Nephritis tubulointerstitial. I totonu: Goldman L, Schafer AI, eds. Faʻafomaʻi Goldman-Cecil. 25th lomiga. Filatelefaia, PA: Elsevier Saunders; 2016: mata 122.

Perazella MA, Rosner MH. Faʻamaʻi o le tubulointerstitial I: Yu ASL, Chertow GM, Luyckx VA, Marsden PA, Skorecki K, Taal MW, eds. Brenner ma Rector's Le Fatugaʻo. 10 ed. Filatelefia, PA: Elsevier; 2020: chap 35.

Tanaka T, Nangaku M. Chronicle interstitial nephritis. I le: Feehally J, Floege J, Tonelli M, Johnson RJ, eds. Faʻamatalaga auʻiliʻi. 6th ed. Filatelefia, PA: Elsevier; 2019: chap 62.