Polyarteritis nodosa

O le Polyarteritis nodosa o se faʻamaʻi o le alatoto toto. O alatoto laiti ma feololo na fefete ma faaleagaina.

O alatoto o vaʻa toto ia e aveina le tele o le okesene ile toto ma totoga. Le mafuaʻaga ole polyarteritis nodosa e leʻo iloa. E tupu le tulaga pe a osofaʻia e nisi sela puipuia le alatoto ua aʻafia. O sela na e fafagaina e alatoto ua afaina e le maua le okesene ma meaai latou te manaʻomia. Faʻaleagaina tupu o se faʻaiuga.

Sili atu tagata matutua nai lo tamaiti maua i lenei faamai.

Tagata e maua i le hepatitis B poʻo le hepatitis C e ono aʻafia i lenei faʻamaʻi.

O faʻailoga e mafua mai i le faʻaleagaina o totoga aʻafia. O le paʻu, sooga, maso, manava o le manava, fatu, fatugaʻo, ma neura e masani ona afaina.

Faʻailoga aofia ai:

• Tiga o le manava
• Faʻaitiitia le fiaai
• Le lavava
• Fiva
• Tiga soʻofaʻatasi
• Ua tiga maso
• Leiloa leiloa mamafa mamafa
• Vaivaiga

Afai e afaina neura, oe ono i ai le leai o se mafaufau, tiga, mu, ma vaivaiga. O le faʻaleagaina o neula e ono mafua ai le lavea poʻo le faʻapoʻe.

E leai ni faʻapitoa suʻesuʻega suʻesuʻega e avanoa e faʻamaonia ai le polyarteritis nodosa. E i ai le numera o faʻaletonu e i ai foliga foliga tutusa ma polyarthritis nodosa. Ua taʻua ia o "mimics."

O le a faia sau suʻega faʻamalositino atoa.

Lab faʻataʻitaʻiga e mafai ona fesoasoani faia le faʻamaoniga ma faʻateʻa faʻataʻitaʻi aofia ai:

• Faitau atoa le toto (CBC) ma le eseʻesega, foafoa o sela, tui mo le hepatitis B ma le C, ma le urinalysis
• Fua faatatau sedryation Erythrocyte (ESR) poʻo C-toe faʻamalosia polotini (CRP)
• Serum porotini electrophoresis, cryoglobulins
• Serum lagolago tulaga
• Arteriogram
• Fuafua biopsy
• O isi suʻega toto o le a faia e faʻateʻa ai tulaga tutusa, pei o systemic lupus erythematosus (ANA) poʻo le granulomatosis ma le polyangiitis (ANCA)
• Suʻega mo le HIV
• Cryoglobulins
• Aneti anti-phospholipid
• Toto aganuu

Togafitiga aofia ai vailaʻau e taofiofia le fulafula ma le puipuiga o le tino. E mafai ona aofia ai vailaʻau, pei ole prednisone. O vailaʻau faʻapena, e pei ole azathioprine, methotrexate poʻo mycophenolate e faʻatagaina mo le faʻaititia o le inumaga o vailaʻau e masani foʻi ona faʻaaogaina. Cyclophosphamide e faʻaaogaina i ni tulaga ogaoga.

Mo polyarteritis nodosa fesoʻotaʻi ma le hepatitis, togafitiga ono aofia ai plasmapheresis ma antiviral vailaʻau.

Togafitiga o loʻo iai nei ma vailaʻau faʻafomai ma isi vailaʻau o loʻo taofiofi ai le malosiʻaga puipuia (pei ole azathioprine poʻo le cyclophosphamide) e mafai ona faʻaleleia atili ai faʻailoga ma le avanoa e ola ai i se taimi umi.

O faʻalavelave e sili ona matuia e masani ona aʻafia ai fatugaʻo ma alaala gastrointestinal.

A aunoa ma togafitiga, o le vaʻaiga e leaga.

Faʻafitauli e ono aofia ai:

• Maʻi fatu
• Nusipepa nekrosis ma perforation
• Le manuia fatugaʻo
• Pa

Valaʻau lau fomaʻi pe a fai e te maua faʻailoga o lenei faʻamaʻi. O le vave suʻesuʻe ma togafitiga e ono faʻaleleia ai le avanoa e maua ai se iʻuga lelei.

E leai se iloa puipuia. Ae ui i lea, o togafitiga vave e mafai ona puipuia ni faʻaleagaina ma faʻailoga.

Periarteritis nodosa; PAN; Faʻamalosi tino neegizing vasculitis

• Polycularitis microscopic 2
• Faiga faʻasolosolo

Luqmani R, Awisat A. Polyarteritis nodosa ma faʻafitauli e fesoʻotaʻi. I totonu: Firestein GS, Budd RC, Gabriel SE, Koretzky GA, McInnes IB, O'Dell JR, eds. Firestein & Kelley's Textbook of Rheumatology. 11th lomiga. Filatelefia, PA: Elsevier; 2021: mata 95.

Puéchal X, Pagnoux C, Baron G, et al. Faʻaopopo azathioprine i remission-faʻasolosolo glucocorticoids mo eosinophilic granulomatosis ma polyangiitis (Churg-Strauss), microscopic polyangiitis, poʻo polyarteritis nodosa e aunoa ma le leaga ramalanoa mea: a faʻasolosolo, pulea faʻataʻitaʻiga. Gugu Rheumatol. 2017; 69 (11): 2175-2186. PMID: 28678392 www.pubmed.ncbi.nlm.nih.gov/28678392/.

Shanmugam VK. Vasculitis ma isi mea e le masani ai. I: Sidawy AN, Perler BA, eds. Rutherford's Vascular Surgery ma Endovascular Therapy. 9th ed. Filatelefia, PA: Elsevier; 2019: chap 137

Maa JH. Le vasculitides faiga. I totonu: Goldman L, Schafer AI, eds. Faʻafomaʻi Goldman-Cecil. 26th lomiga. Filatelefia, PA: Elsevier; 2020: chap 254.