Tofotofoga toto TBG

O le suʻega ole toto ole TBG e fua ai le maualuga ole polotini e faʻagaioia le thyroid hormone i lou tino atoa. O lenei polotini ua taʻua ole thyroxine binding globulin (TBG).

Ua ave se faʻataʻitaʻiga ole toto ona lafo lea i le potu suesue mo suʻesuʻega.

Nisi vailaʻau ma vailaʻau mafai ona afaina ai faʻaiuga suʻega. E ono taʻu atu e lau tausi soifua maloloina ia te oe e taofi le toe inuina o se vailaʻau mo sina taimi puʻea ae leʻi faia le suʻega. Aua le taofia le inuina o se vailaʻau e aunoa ma le talanoa muamua i lau tautua.

O nei vailaʻau ma fualaʻau mafai faʻateleina TBG tulaga:

• Estrogens, o loʻo maua i fualaʻau e fomaʻi ma fofo ai le estrogen
• Heroin
• Methadone
• Phenothiazines (nisi vailaʻau antipsychotic)

O vailaʻau nei e mafai ona faʻaititia ai tulaga ole TBG:

• Depakote poʻo depakene (e taʻua foi o le valproic acid)
• Dilantin (e taʻua foi o le phenytoin)
• Maualuga tui o salicylates, aofia ai aspirin
• Tane homone, aofia ai androgens ma testosterone
• Prednisone

A faʻaofi le nila e toso le toto, o nisi tagata e lagona le feololo tiga. O isi e naʻo se tuitui poʻo se tui e lagona. A maeʻa, atonu e i ai se tuitui poʻo sina tiga. Lenei vave alu ese.

O lenei suʻega e mafai ona faia e faʻamaonia ai faʻafitauli i lou tiroida.

O le tulaga masani e 13 i le 39 microgram i le deciliter (mcg / dL), poʻo le 150 i le 360 ​​nanomoles ile lita (nmol / L).

E masani ona fesuisuiaʻi vaega eseese o tau masani ile falefaigaluega eseese. O nisi fale suʻesuʻe e faʻaaoga eseese fuataga pe ono suʻesuʻe eseʻese faʻataʻitaʻiga. Talanoa i lau tautua e uiga i le uiga o au faʻapitoa suʻega iʻuga.

O le faʻateleina ole tulaga ole TBG e ono mafua mai ile:

• Porphyria soʻona faʻamamaina (o se le masani ai faʻafitauli i le tino)
• Hypothyroidism (le toaga galue)
• Maʻi ole ate
• Maitaga (TBG tulaga masani faʻateleina i le taimi o maitaga)

Faʻaaliga: TBG maualuga e masani ona maualuga i pepe faatoa fananau mai.

O le paʻu o le TBG tulaga e ono mafua mai i:

• Maʻi tuga
• Acromegaly (faʻafitauli mafua mai i le tele tuputupu ae homone)
• Hyperthyroidism (ova tele lou thyroid)
• Paleni meaai
• Faʻamaʻi nephotic (faʻailoga e faʻaalia ai le faʻaleagaina fatugaʻo o loʻo iai)
• Faʻafitauli mai taotoga

Maualuga pe maualalo le maualuga TBG aafia ai le sootaga ile va o le T4 atoa ma le maua fua T4 toto suʻega. Ole fesuiaiga ile maualuga ole toto ole TBG e mafai ona suia ai le tui talafeagai ole sui ole levothyroxine mo tagata e maua ile hypothyroidism.

E i ai laʻititi se aʻafiaga e ono aafia ai i lou aveina o lou toto. O uaua ma alatoto e eseese i le tele mai le tasi tagata i le isi ma mai le tasi itu o le tino i le isi. Mauaina o se toto faʻataʻitaʻiga mai nisi tagata ono faigata sili atu nai lo isi.

O isi aʻafiaga o le tosoina o le toto e laʻititi, ae mafai ona aofia ai:

• Toto tele
• Faaseʻe pe lagona le mumu o le ulu
• Tele tui e suʻe ai uaua
• Hematoma (faʻaputuputu toto i lalo o le paʻu)
• Faamaʻi (o se laʻititi tulaga lamatia soʻo se taimi le paʻu ua paʻu)

Serum thyroxine fusia globulin; Tulaga TBG; Serum tulaga TBG; Hypothyroidism - TBG; Hyperthyroidism - TBG; Tou te le galue malosi - TBG; Ova tele lou thyroid - TBG

• Tofotofoga toto

Guber HA, Farag AF. Iloiloga o galuega endocrine. I totonu: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management e le Laboratory Metotia. 23rd ed. St Louis, MO: Elsevier; 2017: mata 24.

Kruse JA. Faʻafitauli o le thyroid I le: Parrillo JE, Dellinger RP, eds. Vailaau Faʻamataʻu Mataʻutia: Mataupu faʻavae o Suʻesuʻega ma Pulega i Tagata Matutua. 5th ed. Filatelefia, PA: Elsevier; 2019: chap 57.

Salvatore D, Cohen R, Kopp PA, Larsen PR. Tiroida pathophysiology ma iloiloga faʻamaoniga. I: Melmed S, Auchus RJ, Goldfine AB, Koenig RJ, Rosen CJ, eds. Williams Tusitusiga o Endocrinology. 14th lomiga. Filatelefia, PA: Elsevier; 2020: mata 11.