Monoclonal antodies: o a latou ma aisea latou te fesoasoani ai e togafitia faʻamaʻi

Anotusi

• Faʻataʻitaʻiga o monoclonal antibodies
• 1. Trastuzumab
• 2. Denosumab
• 3. Obinutuzumab
• 4. Ustequinumab
• 5. Pertuzumab
• Faʻafefea ona Ave le Monoclonal Antibodies

O le monoclonal antibodies o ni polotini na faʻaaogaina e le immune system e faʻailoa ma faʻamama ai tino mai fafo, e mafai ona avea ma siama, siama poʻo ni sela tumo. O nei polotini e faʻapitoa lava, aua latou te amanaʻia se faʻatatauga taua, o le mea e taʻua o le antigen, lea o le a iai i sela ese mai le tino. Malamalama pe faʻafefea ona aoga le puipuiga.

Monoclonal antodies, pei o le denosumab, obinutuzumab poʻo le ustequinumab, mo se faʻataʻitaʻiga, e gaosia i le fale suʻesuʻe, e masani ona tutusa ma mea na maua i le tino o le tagata, e fesoasoani ai i le tino e tau ai faʻamaʻi. O le mea lea, faʻalagolago i le monoclonal antibody o loʻo faʻaaogaina, o nei fofo e mafai ona faʻaaogaina e togafitia ai nisi o faʻamaʻi ogaoga e pei o le osteoporosis, kanesa o le toto, faʻamaʻi psoriasis poʻo ni ituaiga o kanesa, pei o le susu poʻo le ponaivi kanesa, mo se faʻataʻitaʻiga.

Faʻataʻitaʻiga o monoclonal antibodies

Nisi faʻataʻitaʻiga o monoclonal antibodies aofia ai:

1. Trastuzumab

O lenei monoclonal antibody, na faʻatau atu e pei o Herceptin, na atiaʻe e le inisinia faʻasaienisi, ma osofaʻia faʻapitoa ai le polotini o loʻo iai i tagata e iai ma le kanesa o le susu ma le manava. O le mea lea, o lenei vailaʻau o loʻo faʻailoa mai mo le togafitia o le kanesa o le susu i se amataga poʻo le metastasis ma le kanesa o le manava i se tulaga alualu i luma.

2. Denosumab

Faʻatau e pei ole Prolia poʻo le Xgeva, o loʻo iai i lona tuʻufaʻatasia le tagata monoclonal IgG2 antibody, lea e faʻalavelave i le gaioiga a se polotini faʻapitoa e faʻamalosia ai ponaivi, faʻaititia ai avanoa e gagau ai. O le mea lea, Denosumab o loʻo faʻailoa mai mo le togafitia o ponaivi leiloa leiloa, osteoporosis, ponaivi kanesa poʻo kanesa i tulaga alualu i luma i ponaivi metastases (lea ua salalau atu i ponaivi).

3. Obinutuzumab

Faʻailoa foʻi faʻapisinisi o Gazyva, o loʻo i ai i totonu o lona tino vailaʻau e iloa ma fusia faʻapitoa i le polotini CD20, o loʻo maua i luga o sela papaʻe o le tino poʻo lymphocytes B. O lea, o le obinutuzumab o loʻo faʻailoa mai mo le togafitia o leukimia masani o le lymphocytic, e pei ona iai. mafai ona taofi le faʻatupulaia le tuputupu aʻe o sela papaʻe toto e mafua ai lenei faʻamaʻi.

4. Ustequinumab

Lenei fofo ono mafai foi ona lauiloa faʻapisinisi o Stelara ma e aofia ai le tagata IgG1 monoclonal antibody, lea e taofiofia ai polotini faʻapitoa e gafa ma le mafuaʻaga o le psoriasis. O le mea lea, o lenei fofo ua faʻailoaina mo le togafitiga o faʻamaʻa psoriasis.

5. Pertuzumab

Faʻailoa foi o leetaetaʻi, o loʻo faia i monoclonal antodies e fusifusia i le tagata epidermal tuputupu aʻe vaega 2 resitara, o loʻo i ai i nisi sela sela, faʻatelegese pe taofiina lo latou tuputupu aʻe. O le mea lea, Perjeta ua faʻailoa mo le togafitia o le kanesa o le susu.

Faʻafefea ona Ave le Monoclonal Antibodies

O vailaʻau ma Monoclonal Antibodies e tatau ona ave i lalo o fautuaga faʻafomaʻi, ona o le ituaiga o vailaʻau e faʻaaogaina ma o vailaʻau fautuaina e faʻamoemoeina ile faʻafitauli e togafitia ma lona ogaoga.

I le tele o tulaga, o nei fofo e faʻaaogaina i le togafitia o le kanesa, ona o antineoplastic fofo e tatau ona faʻaaogaina e tusa ai ma faʻatonuga faʻapitoa na tuʻuina mai e le fomaʻi ma e manaʻomia ona faʻatautaia i falemaʻi poʻo falemaʻi.