O a vailaʻau faʻasaina?

Anotusi

• Faʻafefea ona latou galue
• Ituaiga o vailaʻau antifungal
• Azoles
• Polyenes
• Allylamines
• Echinocandins
• Eseese
• Faʻamaʻi pipisi
• Faʻailoga o le faʻamaʻi pipisi
• Faʻailoga o sili atu ogaoga siama fungal
• O afea e vaʻai ai i se fomaʻi
• Le pito i lalo

Fungi mafai ona maua i le lalolagi atoa i ituaiga uma o siʻosiʻomaga. Tele fungi e le mafua ai faʻamaʻi i tagata. Peitaʻi, o nisi ituaiga e mafai ona aʻafia tagata ma mafua ai maʻi.

O vailaʻau faʻafomaʻi o vailaʻau ia e faʻaaoga e togafitia ai faʻamaʻi iniseti. E ui o le tele o faʻamaʻi pipisi e afaina ai vaega e pei o le paʻu ma fao, o nisi e mafai ona oʻo atu ai i ni tulaga ogaoga ma ono lamatia ai le ola pei o le fiva faiʻai poʻo le niumonia.

E tele ituaiga o vailaʻau antifungal o loʻo avanoa e tau ai faʻafitauli oona.

Faʻafefea ona latou galue

I se tulaga lautele, e mafai ona aoga vailaʻau antifungal i ni auala se lua: e ala i le fasiotia saʻo o sela poʻo le puipuia o laulaʻau mai le tutupu ma olaola. Ae faʻafefea ona latou faia lenei mea?

O vailaʻau faʻamalosi tino e faʻatatau i fausaga poʻo gaioiga e manaʻomia i siama niniʻi ae leʻo totonu o sela o tagata, ina ia mafai ai ona latou tauina se faʻamaʻi pipisi e aunoa ma le faʻaleagaina o sela o lou tino.

Lua fausaga e masani ona faʻatutuina o le fungal sela membrane ma le kulimi sela pa. Uma nei fausaga siʻoina ma puipuia le fungal sela. A faʻaleagaina uma seisi, e mafai ona pa le oti le sela ma oti.

Ituaiga o vailaʻau antifungal

O vailaʻau faʻamamalu e matua eseʻese lava. E mafai ona tuʻuina atu i latou i gutu, o se togafitiga autu, pe ala i le IV. Faʻafefea ona tuʻuina se vailaʻau antifungal faʻalagolago i mea taua e pei o le faʻapitoa vailaʻau, le ituaiga o faʻamaʻi ua e maua, ma le ogaoga o lou faʻamaʻi.

O vailaʻau faʻamamalu e faʻavasegaina e a latou vailaʻau vailaʻau faʻapea foi pe faʻafefea ona latou galue. Lalo, o le a matou talanoaina ituaiga eseese o vailaʻau antifungal ma avatu ni faʻataʻitaʻiga o ituaiga o siama latou te togafitia.

Azoles

Azoles o nisi ia o antifungals e masani ona faʻaaogaina. Latou te faʻalavelave i se enzyme e taua mo le fausiaina o le fungal cell membrane. Ona o lenei, o le sela sela ua le mautonu ma mafai ona paʻu, ma iu ai i le oti sela.

E lua vaega o azole antifungals: imidazoles ma triazoles.

Faʻataʻitaʻiga o imidazole antifungals ma tuutuuga latou te togafitia o:

• Ketoconazole: faʻamaʻi o le paʻu ma lauulu, Candida faʻamaʻi o le paʻu ma mucous membrane, blastomycosis, histoplasmosis
• Clotrimazole: paʻu ma mucous membrane siama
• Miconazole: paʻu ma mucous membrane siama

Nisi faʻataʻitaʻiga o triazoles ma tuutuuga latou te togafitia o:

• Fluconazole:Candida faʻamaʻi pipisi, e aofia ai mucosal, tino, ma faʻamaʻi pipisi; cryptococcosis
• Itraconazole: aspergillosis, blastomycosis, histoplasmosis, mucosal Candida faʻamaʻi, coccidioidomycosis (leai se igoa), ma le onychomycosis
• Posaconazole: aspergillosis (ese-igoa mo togafitiga), mucosal ma osofaʻiga Candida faʻamaʻi pipisi
• Voriconazole: aspergillosis, mucosal pe faʻamataʻu Candida faʻamaʻi, faʻamaʻi pipisi ma Fusarium ituaiga
• Isavuconazole: aspergillosis ma le mucormycosis

Polyenes

E faʻaumatia e le Polyenes sela fasimea e ala i le faʻateleina o le porous i le puipui o le sela na mafua ai ona pa.

O ni faʻataʻitaʻiga o vailaʻau o vailaʻau o:

• Amphotericin B: eseese formulasi e avanoa e togafitia aspergillosis, blastomycosis, cryptococcosis, histoplasmosis (ese-igoa), mucosal po o osofaʻiga Candida faʻamaʻi, ma le coccidioidomycosis
• Nystatin:Candida faʻamaʻi o le paʻu ma le gutu

Allylamines

E pei o le azole antifungals, allylamines faʻalavelave i se enzyme o loʻo aʻafia i le fausiaina o le fungal sela membrane. O se tasi faʻataʻitaʻiga o le allylamine o le terbinafine, lea e masani ona faʻaaoga e togafitia ai faʻamaʻi iniseti o le paʻu.

Echinocandins

Echinocandins o se fou fou o antifungal vailaʻau. Latou te taofia se enzyme o loʻo aʻafia i le faiga o le fungal cell wall.

O ni faʻataʻitaʻiga o echinocandins o:

• Anidulafungin: mucosal ma osofaʻiga Candida faʻamaʻi pipisi
• Caspofungin: mucosal ma osofaʻiga Candida faʻamaʻi pipisi, aspergillosis
• Micafungin: mucosal ma osofaʻiga Candida faʻamaʻi pipisi

Eseese

E i ai foi isi ituaiga o vailaʻau antifungal. Nei i ai auala eseʻese mai ituaiga na matou talanoaina luga.

Flucytosine o se antifungal e puipuia le fungal sela mai le faia o nucleic acid ma polotini. Ona o lea, ua le toe mafai ai ona tupu ma ola le sela. Flucytosine mafai ona faʻaaogaina e togafitia ai faʻafitauli siama ma Candida pe Cryptococcus ituaiga

Griseofulvin galue e puipuia le kulimi sela mai le vaeluaina e maua ai sili sela. E mafai ona faʻaaoga e togafitia ai faʻamaʻi o le paʻu, lauulu ma fao.

Faʻamaʻi pipisi

E tele ituaiga o siama inifeti. E mafai ona e maua i se faʻamaʻi pipisi e ala i le faʻafesoʻotaʻiina o se fungus poʻo ni vailaʻau o loʻo i ai i le siosiomaga.

O nisi o faʻamaʻi pipisi e masani ona afaina ai le paʻu, fao, ma muʻa. O faʻataʻitaʻiga e aofia ai:

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  Faʻailoga o le faʻamaʻi pipisi

  O faʻailoga o nisi o masani masani o faʻamaʻi papala e mafai ona aofia ai:

  • Ringworm o le tino: o le mageso, e ono mageso i le tino i ou tino, lima poʻo ou vae
  • Ringworm o le ulu o le ulu: o lauʻulu faʻamamaina, pustules, poʻo ni maa faʻamau i luga o lou ulu e mageso ma ono agamalu ma mafua ai le paʻu lauulu.
  • Vae o tagata taalo: paʻu paʻu i lalo o ou vae
  • Jock mageso: o le mageso, mumu mageso e aliali mai i lau 'auvae ma luga o ou ogavae i totonu
  • Fao taliga: atigilima na suia foliga, magaugofie ma faʻaletino
  • Faʻamaʻi pipisi fefete: mageso, mūmū, ma le fulafula i le itutino vaʻa - mafiafia paʻepaʻe tulimanu paʻu ma se mu lagona pe a urination ono tupu foi
  • Luga gutu: atinaʻe o papaʻe papaʻe i lou gutu atonu e mumu ma tiga

  Faʻailoga o sili atu ogaoga siama fungal

  O faʻailoga o nisi o faʻamaʻi iniseti sili ona ogaoga e mafai ona fesuisuiaʻi faʻamoemoe i ituaiga o fungi o loʻo mafua ai le faʻamaʻi ma le vaega o lou tino ua afaina.

  E mafai ona aofia ai mea e pei o:

  • fiva
  • afu le po
  • fulū-pei o faʻailoga, pei o le tiga o le ulu, lelava, ma tiga o le tino ma tiga
  • faʻailoga manava e pei o tale ma manava puʻupuʻu
  • auga o le fiva faiʻai, pei o le tiga o le ulu, ua maʻaʻa, ma le malamalama ma le malamalama

  O afea e vaʻai ai i se fomaʻi

  Fai se taimi ma lau fomaʻi pe a fai:

  • e leʻi galue antifungals o le counter-counter (OTC) e faʻamalolo ai faʻailoga o faʻamaʻi pei o ringworm, nail fungus, poʻo se siama faʻafefeteina i le puta.
  • le faʻamatalaina papaʻe papaʻe tupu i lou gutu
  • ua e maua i le fiva, faʻamaʻi pei o le fulū, poʻo le papala o le papala ma / pe ua e masalomia se faʻamaʻi fiva

  E i ai ni faʻailoga e tatau ai ona e sailia vave togafitiga faʻafomaʻi

  E aofia ai:

  • tiga o le fatafata
  • faigata ona manava
  • tale i luga le toto
  • auga o le fiva faiʻai, pei o le tiga o le ulu, ua maʻaʻa, ma le malamalama ma le malamalama
  • le mafaamatalaina mamafa leiloa, fiva, pe malulu

  Le pito i lalo

  O vailaʻau faʻamalosi e faʻaaoga e togafitia ai faʻamaʻi iniseti. Latou faʻatutuina gaioiga ma faʻavae tulaga ese i fungus i le mea e mafai ai ona fasioti fungal sela pe puipuia i latou mai le tutupu.

  E tele ituaiga o vailaʻau antifungal, ma e mafai ona tuʻuina atu i latou i auala eseese. O le ituaiga vailaʻau na faʻaaogaina ma le auala e faʻatautaia ai e mafai ona faʻalagolago i le vailaʻau ma le ituaiga ma le ogaoga o le faʻamaʻi.

  E ui o le tele o ituaiga o siama inifeti e faigofie ona togafitia, o nisi e mafai ona ogaoga. Vaʻai lau fomaʻi pe a fai e le alu se faʻamaʻi toto i le togafitiga o le OTC pe a e masalomia o loʻo iai se faʻamaʻi gaugala sili atu ona leaga.