Tusitala: Gregory Harris
Aso O Foafoaga: 11 Apelila 2021
Faafouga Aso: 23 Setema 2024
Anonim
BRAF Mutations Across Cancers
Ata: BRAF Mutations Across Cancers

Anotusi

O le a le suʻega ole gafa ole BRAF?

O le suʻega ole gafa ole BRAF e suʻea se suiga, e taʻua o le fesuiaʻiga, i se kenera e taʻu ole BRAF. O kenera o vaega faʻavae ia o lona tupuʻaga na tuʻufaʻatasia mai lou tina ma lou tama.

O le BRAF gaʻo faia se polotini e fesoasoani faʻatonutonu sela tupu. E lauiloa o le oncogene. O le oncogene e galue pei o le kesi uila i luga o se taʻavale. E masani lava, ole oncogene liliu ile sela tupuola pe a manaʻomia. Ae afai e iai sau fesuiaʻiga o le BRAF, e pei lava o le kesi uila ua mau i lalo, ma e le mafai e le kenera ona taofi sela mai le ola. O le le faʻatonutonu o le tupu aʻe o sela e mafai ai ona maua i le kanesa.

O le BRAF suiga e mafai ona maua mai i ou matua pe maua mulimuli ane i le olaga. O fesuiaʻiga e tupu mulimuli ane i le olaga e masani ona mafua mai i le siosiomaga pe mai se mea sese e tupu i lou tino i le taimi o vaevaega sela. E seasea lava maua ni suiga o tofi BRAF, peitaʻi e ono tutupu mai ai ni faʻafitauli tuga i le soifua maloloina.

Mauaina (iloa foi o somatic) BRAF suiga e sili atu ona taatele. O nei suiga ua maua i le tusa o le afa o tulaga uma o le melanoma, o le ituaiga ogaoga o kanesa o le paʻu. O le BRAF mutation e masani ona maua i isi faʻaletonu ma ituaiga eseese o kanesa, e aofia ai kanesa o le kolone, thyroid, ma ovaries. O faʻamaʻi pipisi ma le BRAF mutation e foliga mai e sili atu le ogaoga nai lo i latou e leai se suiga.


Isi igoa: BRAF gene mutation analysis, Melanoma, BRAF V600 mutation, cobas

O le a le mea e faʻaaoga ai?

O le suʻega e masani ona faʻaaoga e suʻe ai se suiga o le BRAF i tagata mamaʻi e iai le melanoma poʻo isi kanesa e faʻatatau i le BRAF. Nisi vailaʻau kanesa e sili ona aoga i tagata o loʻo iai le fesuiaʻiga ole BRAF. O vailaʻau lava e tasi e le mataalia ma o nisi taimi mataʻutia i tagata e leai ni suiga.

E mafai foʻi ona faʻaaoga le suʻega ole BRAF e te iloa ai o oe i se tulaga lamatia mo kanesa faʻavae i talaʻaga o aiga ma / poʻo lau oe lava talaʻaga soifua maloloina.

Aisea ou te manaʻomia ai se BRAF genetic test?

Atonu e te manaʻomia le faʻataʻitaʻiga ole BRAF peʻa faʻapea ua e maʻi ile melanoma poʻo seisi ituaiga kanesa. O le iloa pe o iai sau fesuiaʻiga e mafai ona fesoasoani i lau tautua tuʻuina atu le saʻo togafitiga.

Oe ono manaʻomia foi lenei suʻega e vaʻai pe o oe i se maualuga maualuga lamatiaga mo le kanesa. O mea matautia e aofia ai le talaʻaga o le aiga o le kanesa ma / poʻo le maua o le kanesa i le amataga o lona matua. Ole tausaga faʻapitoa e faʻamoemoe ile ituaiga kanesa.


O le a le mea e tupu i le taimi o le BRAF gaʻoa?

Ole tele ole suʻega ole BRAF e faia ile auala e taʻua ole tumo biopsy. I le taimi o le biopsy, o le a aveese ai e se tausi soifua maloloina se tamaʻi fasi mea e ala i le tipiina poʻo le oloina o le pito i luga o le tumo. Afai e manaʻomia e lau tautua le suʻega o le tuma mai totonu o lou tino, e ono faʻaaoga e ia se nila faʻapitoa e aveʻese mai ai le faʻataʻitaʻiga.

Mata e tatau ona ou faia se mea e sauniuni ai mo le suʻega?

E masani ona e le manaʻomia ni sauniuniga faʻapitoa mo se suʻega BRAF.

E i ai ni lamatiaga i le suʻega?

E i ai sina manuʻa poʻo se toto i le nofoaga na fausia ai le biopsy. E i ai foi sina faʻaletonu i le 'upega tafaʻilagi mo se aso pe lua.

O le a le uiga o faʻaiuga?

A faʻapea e iai lou melanoma poʻo seisi ituaiga kanesa, ma o iʻuga e faʻaalia ai o loʻo iai sau fesuiaʻiga o le BRAF, e mafai e lau kamupani tuʻuina atu talavai ni vailaʻau ua fuafuaina e faʻatutu ai le suiga. O nei vailaʻau e mafai ona sili atu le aoga nai lo isi togafitiga.

A faʻapea e maua oe ile melanoma poʻo seisi ituaiga kanesa, ma o iʻuga e te iloa ai aua i ai se fesuiaiga, o le a faʻavasegaina e lau kamupani tuʻufaʻatasiga ituaiga vailaʻau e togafitia ai lou kanesa.


Afai e te leʻi faʻamaonia i le kanesa ma o au iʻuga faʻaalia ai o loʻo ia oe le BRAF genetation mutation leai o lona uiga ua maua oe ile kanesa, ae e maualuga atu lou aʻafiaga o le kanesa. Ae o le tele o taimi e siaki ai le kanesa, pei o le suʻega o le paʻu, e mafai ona faʻaititia ai lou aʻafiaga. I le taimi o le suʻega o le paʻu, e vaʻaia ma le faʻaeteete e se tausi soifua maloloina le paʻu o lou tino atoa e siaki ai isumu ma isi masalomia o tutupu aʻe.

Talanoa i lau tautua e uiga i isi laʻasaga e mafai ona e faia e faʻaititia ai lou tulaga lamatia.

Aʻoaʻo atili e uiga i suʻesuʻega falesuesue, vaitau o faʻasino, ma malamalamaaga i iʻuga

E iai se isi mea e tatau ona ou iloa e uiga ile suʻega ole BRAF?

Atonu e te faʻalogo ile au tautua e uiga ile V600E suiga. E i ai ituaiga eseese o BRAF suiga. V600E o le sili ona taatele ituaiga o BRAF suiga.

Faʻamatalaga

  1. American Cancer Society [Initaneti]. Atlanta: American Cancer Society Inc. c2018. Melanoma Paʻu Kanesa; [taʻua 2018 Jul 10]; [pe tusa ma le 3 pupuni] Avanoa mai: https://www.cancer.org/cancer/melanoma-skin-cancer.html
  2. American Cancer Society [Initaneti]. Atlanta: American Cancer Society Inc. c2018. Oncogenes ma genes suppressor genes; [faafouina 2014 Jun 25; taʻua 2018 Jul 10]; [tusa o le 4 pupuni] Avanoa mai: https://www.cancer.org/cancer/cancer-causes/genetics/genes-and-cancer/oncogenes-tumor-suppressor-genes.html
  3. American Cancer Society [Initaneti]. Atlanta: American Cancer Society Inc. c2018. Fuafua faʻapitoa mo Melanoma Paʻu Kanesa; [faafou 2018 Jun 28; taʻua 2018 Jul 10]; [pe tusa ma le 3 pupuni] Avanoa mai: https://www.cancer.org/cancer/melanoma-skin-cancer/treating/targeted-therapy.html
  4. Cancer.Net [Initaneti]. Alexandria (VA): American Society of Clinical Oncology; c2005–2018. Suʻesuʻega faʻafuaseʻi mo kanesa kanesa; 2017 Jul [taʻua 2018 Jul 10]; [tusa o le 4 pupuni] Avanoa mai: https://www.cancer.net/navigating-cancer-care/cancer-basics/genetics/genetic-testing-cancer-risk
  5. Cancer.Net [Initaneti]. Alexandria (VA): American Society of Clinical Oncology; c2005–2018. Malamalama i togafitiga faʻatulagaina; 2018 Me [taʻua 2018 Jul 10]; [tusa o le 4 pupuni] Avanoa mai: https://www.cancer.net/navigating-cancer-care/how-cancer-treated/personalized-and-targeted-therapies/understanding-targeted-therapy
  6. Integrated Oncology [Initaneti]. Laboratory Corporation o Amerika; c2018. BRAF Gene Mutation Iloiloga; [taʻua 2018 Jul 10]; [pe tusa ma le 3 pupuni] Avanoa mai: https://www.integratedoncology.com/test-menu/braf-gene-mutation-analysis/07d322d7-33e3-480f-b900-1b3fd2b45f28
  7. Lab Tofotofoga lugalaina [Initaneti]. Washington D.C: American Association mo vailaʻau Togafitiga; c2001–2018. Biopsy; [faafou 2017 Jul 10; taʻua 2018 Jul 10]; [pe a ma le 2 pupuni] Avanoa mai: https://labtestsonline.org/glossary/biopsy
  8. Lab Tofotofoga lugalaina [Initaneti]. Washington D.C .: American Association mo Vailaʻau Togafitiga; c2001–2018. Suʻesuʻega faʻafuaseʻi mo le faʻataʻitaʻia o le kanesa; [faafou 2018 Jul 10; taʻua 2018 Jul 10]; [pe a ma le 2 pupuni] Avanoa mai: https://labtestsonline.org/tests/genetic-tests-targeted-cancer-therapy
  9. Mayo Clinic: Mayo Medical Laboratories [Initaneti]. Mayo Faʻavae mo Aʻoga Faʻafomaʻi ma Suesuega; c1995–2018. ID faʻataʻitaʻi: BRAFT: BRAF Mutation Analysis (V600E), Tumor: Clinical and Interpretive; [taʻua 2018 Jul 10]; [tusa o le 4 pupuni] Avanoa mai: https://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/35370
  10. National Cancer Institute [Initaneti]. Bethesda (MD): U.S. Matagaluega o le Soifua Maloloina ma Tagata Auaunaga; Suʻesuʻega faʻafuaseʻi mo tupuʻaga o kanesa tupuʻaga; [taʻua 2018 Jul 10]; [pe tusa ma le 3 pupuni] Avanoa mai: https://www.cancer.gov/about-cancer/causes-prevention/genetics/genetic-testing-fact-sheet
  11. National Cancer Institute [Initaneti]. Bethesda (MD): U.S. Matagaluega o le Soifua Maloloina ma Tagata Auaunaga; NCI Lomifefiloi o Kanesa Aiaiga: BRAF gafa; [taʻua 2018 Jul 10]; [pe tusa ma le 3 pupuni] Avanoa mai: https://www.cancer.gov/publications/dictionaries/cancer-terms/def/braf-gene
  12. National Cancer Institute [Initaneti]. Bethesda (MD): U.S. Matagaluega o le Soifua Maloloina ma Tagata Auaunaga; NCI Lomifefiloi o Kanesa Aiaiga: BRAF (V600E) suiga; [taʻua 2018 Jul 10]; [pe tusa ma le 3 pupuni] Avanoa mai: https://www.cancer.gov/publications/dictionaries/cancer-terms/def/braf-v600e-mutation
  13. National Cancer Institute [Initaneti]. Bethesda (MD): U.S. Matagaluega o le Soifua Maloloina ma Tagata Auaunaga; NCI Lomifefiloi o Kanesa Aiaiga: gafa; [taʻua 2018 Jul 10]; [pe tusa ma le 3 pupuni] Avanoa mai: https://www.cancer.gov/publications/dictionaries/cancer-terms/search?contains=false&q=gene
  14. National Cancer Institute [Initaneti]. Bethesda (MD): U.S. Matagaluega o le Soifua Maloloina ma Tagata Auaunaga; NCI Lomifefiloi o Kanesa Aiaiga: oncogene; [taʻua 2018 Jul 10]; [pe tusa ma le 3 pupuni] Avanoa mai: https://www.cancer.gov/publications/dictionaries/cancer-terms/def/oncogene
  15. NIH U.S. National Library of Medicine: Genetics Home Reference [Initaneti]. Bethesda (MD): U.S. Matagaluega o le Soifua Maloloina ma Tagata Auaunaga; Gafa ole BRAF; 2018 Jul 3 [taʻua 2018 Jul 10]; [pe tusa ma le 3 pupuni] Avanoa mai: https://ghr.nlm.nih.gov/gene/BRAF
  16. NIH U.S. National Library of Medicine: Genetics Home Reference [Initaneti]. Bethesda (MD): U.S. Matagaluega o le Soifua Maloloina ma Tagata Auaunaga; O le a le suiga o le kenera ma faʻafefea ona suia suiga?; 2018 Jul 3 [taʻua 2018 Jul 10]; [pe tusa ma le 3 pupuni] Avanoa mai: https://ghr.nlm.nih.gov/primer/mutationsanddisorder/genemutation
  17. Quest Diagnostics [Initaneti]. Quest Diagnostics; c2000–2017. Nofoaga Suʻega: Melanoma, BRAF V600 Mutation, Cobas: Interpretive Guide; [taʻua 2018 Jul 10]; [tusa o le 4 pupuni] Avanoa mai: https://www.questdiagnostics.com/testcenter/testguide.action?dc=TS_BRAF_V600&tabview
  18. Quest Diagnostics [Initaneti]. Quest Diagnostics; c2000–2017. Nofoaga Suʻega: Melanoma, BRAF V600 Mutation, Cobas: Vaaiga aoao; [taʻua 2018 Jul 10]; [pe tusa ma le 3 pupuni] Avanoa mai: https://www.questdiagnostics.com/testcenter/TestDetail.action?ntc=90956
  19. Iunivesite o Rochester Medical Center [Initaneti]. Rochester (NY): Iunivesite o Rochester Medical Center; c2018. Soifua Maloloina Encyclopedia: Melanoma: Targeted Therapy; [taʻua 2018 Jul 10]; [pe a ma le 2 pupuni] Avanoa mai: https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=34&contentid=BMelT14
  20. UW Soifua Maloloina [Initaneti]. Madison (WI): Iunivesite o Wisconsin Falemai ma Falemai Pulega; c2018. Faʻamatalaga o le Soifua Maloloina: Suʻega Faʻaletino o le Paʻu mo Paʻu Kanesa: Vaaiga Aoao I le Suʻega; [faafou 2017 Me 3; taʻua 2018 Jul 18]; [pe a ma le 2 pupuni] Avanoa mai: https://www.uwhealth.org/health/topic/testdetail/physical-exam/hw206422.html#hw206425UW
  21. Soifua Maloloina [Initaneti]. Madison (WI): Iunivesite o Wisconsin Falemai ma Falemai Pulega; c2018. Soifua Maloloina Faʻamatalaga: Paʻu Kanesa, Melanoma: Aotelega Autu; [faafou 2017 Me 3; taʻua 2018 Jul 10]; [pe a ma le 2 pupuni] Avanoa mai: https://www.uwhealth.org/health/topic/major/skin-cancer-melanoma/hw206547.html
  22. UW Soifua Maloloina: Falemai Fanau Fanau Amerika [Initaneti]. Madison (WI): Iunivesite o Wisconsin Falemai ma Falemai Pulega; c2018. Soifua Maloloina Tamaiti: Biopsy; [taʻua 2018 Jul 10]; [pe tusa ma le 3 pupuni] Avanoa mai: https://www.uwhealthkids.org/kidshealth/en/mother/biopsy.html/
  23. Zial J, Hui P. BRAF fesuiaʻiga o faʻataʻitaʻiga i togafitiga togafitiga. Tomai Rev Mol Diagn [Initaneti]. 2012 Mar [taʻua 2018 Jul 10]; 12 (2): 127–38. Avanoa mai: https://www.ncbi.nlm.nih.gov/pubmed/22369373

O faʻamatalaga i luga o lenei 'upega tafaʻilagi e le tatau ona faʻaaogaina e fai ma sui o fomaʻi faʻapitoa togafitiga poʻo fautuaga. Faʻafesoʻotaʻi le au tausi soifua pe a iai ni au fesili e uiga i lou soifua maloloina.

Le Sili Ona Faitau

Vitamini D soona fai e mafai ona togafitia faʻamaʻi
Soifua Maloloina

Vitamini D soona fai e mafai ona togafitia faʻamaʻi

Togafitiga ma vailaʻau D oona inu na faʻaaogaina e togafitia ai autoimmune faʻamaʻi, lea e tupu pe a tali atu le faʻamalo i tino e faa aga i le tino lava ia, mafua ai faʻafitauli e pei o le tele clero...
Lúcia-lima: o le a le mea mo ma faʻafefea ona faʻaaoga
Soifua Maloloina

Lúcia-lima: o le a le mea mo ma faʻafefea ona faʻaaoga

Lúcia-lima, e taʻua foi o le limonete, bela-Luí a, herb -Luí a poʻo doce-Lima, mo e faʻataʻitaʻiga, o e vailaʻau vailaau o loʻo i ai ni uiga filemu ma anti- pa modic, ma e mafai ona faʻ...