Vailaau mo Tagata ma Ulcerative Colitis

Anotusi

• Aminosalicylates (5-ASA)
• Mesalamine
• Sulfasalazine
• Olsalazine
• Balsalazide
• Corticosteroids
• Budesonide
• Prednisone ma prednisolone
• Immunomodulator
• Tocacitinib
• Methotrexate
• Azathioprine
• Merc laptopurine
• Aafiaga o le methotrexate, azathioprine, ma le merc laptopurine
• Biologics
• Aloʻese mai NSAIDs
• Talanoa ma lau fomaʻi

Faatomuaga

O le ulcerative colitis o se ituaiga o faʻamaʻi o le manava o le manava (IBD) e tele na afaina ai le faʻamaʻi (ga tele). E ono faʻatupuina e se tali le talafeagai mai le tino o lou tino. E ui e leai se lauiloa fofo mo ulcerative colitis, tele ituaiga o vailaʻau mafai ona faʻaaogaina e pulea ai auga.

Faʻailoga o le ulcerative colitis mafai ona aofia ai:

• tiga o le manava, le maua se lagona lelei, poʻo ni papala
• manava manava
• toto i le faʻataʻavalevale

Faʻailoga atonu e tumau pe latou te mafai ona sili atu le leaga i le taimi o le mumu-luga.

Eseese vailaʻau e mafai ona faʻaaogaina e faʻaititia ai le fulafula (fulafula ma le faʻatiga), faʻaititia le numera o flare-ups o ia te oe, ma faʻatagaina lau kolone e faʻamalolo. E fa vasega autu o vailaʻau o loʻo faʻaaogaina e togafitia ai tagata e maua i le papala papala.

Aminosalicylates (5-ASA)

Aminosalicylates e manatu e faʻaititia ai faʻailoga o le ulcerative colitis e ala i le faʻaititia o le fulafula i le kolone. O nei vailaʻau o loʻo faʻaaogaina i tagata e feololo i le papala toto papala. E mafai ona latou fesoasoani e faʻamama le afi poʻo le faʻaititia o numera o loʻo ia te oe.

O faʻataʻitaʻiga o nei vailaʻau e aofia ai:

Mesalamine

Mesalamine mafai ona faia tuʻufofoga (i le gutu) o se tuai tuai-faʻamalolo laupapa, faʻalauteleina-tatalaina capsule, poʻo le tuai-faʻamalolo capsule. Mesalamine o loʻo avanoa foi e avea o le rectal supository poʻo le rectal enema.

Mesalamine e avanoa e avea o se lautele vailaʻau i nisi ituaiga. E i ai foʻi isi ituaiga igoa-igoa, pei o Delzicol, Apriso, Pentasa, Rowasa, sfRowasa, Canasa, Asacol HD, ma Lialda.

O aʻafiaga masani a mesalamine e mafai ona aofia ai:

• manava tata
• tiga le ulu
• niniva
• tiga o le manava, manava, ma le le mautonu
• faʻateleina acidity manava poʻo reflux
• puaʻi
• tanu
• mageso

E seasea aʻafia ni aʻafiaga faigata o le mesalamine:

• tiga o le fatafata
• manava puupuu
• le paʻu fatu fatu

Faʻataʻitaʻiga o vailaʻau e mafai e le mesalamine ona fesoʻotaʻi ma:

• thioguanine
• warfarin
• tui puipuia o le varicella zoster

Sulfasalazine

Sulfasalazine e avea e le gutu o se vave-tatalaina poʻo le tuai-faʻamalolo papa. Sulfasalazine o loʻo avanoa e avea ma vailaʻau lautele ma avea ma igoa ole igoa Azulfidine.

O aʻafiaga masani ole sulfasalazine e mafai ona aofia ai:

• leai se fiaai
• tiga le ulu
• niniva
• puaʻi
• manava le fiafia
• faʻaititia le sua o tamaloloa

O isi seasea ae ogaoga aafiaga o le sulfasalazine aofia ai:

• faʻafitauli o le toto e pei o le anemia
• ogaoga tali faʻafitauli e pei o Stevens-Johnson syndrome
• toilalo ate
• fatugaʻo faʻafitauli

Sulfasalazine ono fesoʻotaʻi ma isi vailaʻau, pei o:

• digoxin
• folic acid

Olsalazine

Olsalazine sau o se pusa e te aveina i lou gutu. E avanoa e pei o le igoa-igoa vailaʻau Dipentum. E le avanoa o se lautele vailaʻau.

O aʻafiaga masani ole olsalazine e mafai ona aofia ai:

• manava tata pe tatafe
• tiga i lou manava
• mageso pe mageso

Aafiaga ogaoga o olsalazine mafai aofia:

• faʻafitauli o le toto e pei o le anemia
• toilalo ate
• fatu faʻafitauli e pei o le fatu pao suia ma fulafula o lou fatu

Faʻataʻitaʻiga o vailaʻau e mafai ona faʻafesoʻotaʻi le olsalazine aofia ai:

• heparin
• maualalo-molemoli mamafa heparins pei o le enoxaparin poʻo le dalteparin
• merc laptopurine
• thioguanine
• tui puipuia o le varicella zoster

Balsalazide

O le Balsalazide e ave e le gutu o se capsule poʻo se laupapa. O le kapisi o loʻo avanoa e avea o se vailaʻau lautele ma o le igoa-igoa vailaʻau Colazal. O le laulau e avanoa naʻo le igoa igoa fuʻa Giazo.

O aʻafiaga e masani ona masani ai le palsalazide e mafai ona aofia ai:

• tiga le ulu
• tiga o le manava
• manava tata
• niniva
• puaʻi
• faʻamaʻi manava
• tiga soʻoga

Aafiaga ogaoga o balsalazide mafai aofia:

• faʻafitauli o le toto e pei o le anemia
• toilalo ate

Faʻataʻitaʻiga o vailaʻau e mafai e le balsalazide ona fesoʻotaʻi ma aofia ai:

• thioguanine
• warfarin
• tui puipuia o le varicella zoster

Corticosteroids

O le Corticosteroids e faʻaititia ai le tino o lou tino ile tali atu i le faʻaititia o le mumu i lou tino. O nei ituaiga o vailaʻau o loʻo faʻaaogaina e togafitia ai tagata e feololo ma ogaoga le faʻamaʻi o papala. Corticosteroids aofia ai:

Budesonide

Lua ituaiga o budesonide e faʻamaonia mo ulcerative colitis o faʻalautelega-faʻamalolo papa ma foam sasa. O loʻo avanoa uma e pei ole igoa ole igoa Uceris. Latou te le avanoa o ni vailaʻau lautele.

O aʻafiaga masani a budesonide e mafai ona aofia ai:

• tiga le ulu
• niniva
• faaititia le maualuga o le homone cortisol
• tiga i lou manava i luga
• lelava
• fula
• fuafua
• siama auala urinary
• tiga soʻoga
• papala

Aafiaga ogaoga o budesonide mafai aofia:

• faʻafitauli vaʻai e pei o le glaucoma, faʻamaʻi mata, ma le tauaso
• toto maualuga

Budesonide mafai faʻafesoʻotaʻi ma isi vailaʻau pei o:

• protease inhibitors pei o ritonavir, indinavir, ma le saquinavir, e faʻaaoga e togafitia ai siama o le HIV
• vailaau antifungal pei o itraconazole ma ketoconazole
• erythromycin
• tautala puipuia e iai le ethinyl estradiol

Prednisone ma prednisolone

Prednisone o loʻo avanoa i laulau, tuai-faʻamatuʻu laulau, ma suavaia fomu fomu. Oe aveina nei mea i le gutu. Prednisone o loʻo avanoa e avea ma vailaʻau lautele ma avea ma igoa igoa igoa Deltasone, Prednisone Intensol, ma Rayos.

O ituaiga o prednisolone ua faʻamaonia mo ulcerative colitis o:

• papa maa
• solo laupapa
• suavai fofo
• syrup

E mafai ona e aveina se tasi o nei pepa i le gutu. Prednisolone o loʻo avanoa e avea ma vailaʻau lautele ma pei o le igoa-igoa vailaʻau Millipred.

O aʻafiaga masani ole prednisone male prednisolone e mafai ona aofia ai:

• faʻateleina le suka ile maualuga ole suka
• le mautonu poʻo le popole
• faateleina le toto
• fula e mafua i le taofiofia vai i ou vae poʻo tapuvae
• faateleina le fiaai
• mamafa maua

Aafiaga ogaoga o le prednisone ma le prednisolone e mafai ona aofia ai:

• osteoporosis ma faʻateleina lamatiaga o ponaivi gaui
• fatu faʻafitauli e pei o le fatu oso, tiga o le pusa, ma fatu fatu suia
• faoa faamalosi

Faʻataʻitaʻiga o vailaʻau e mafai e le prednisone ma le prednisolone ona fesoʻotaʻi ma:

• vailaʻau faʻasoesa pei o phenobarbital ma phenytoin
• toto manifinifi pei o warfarin
• rifampin
• ketoconazole
• aspirin

Immunomodulator

Immunomodulator o vailaʻau e faʻaititia ai le tali a le tino i lana ia lava puipuiga. O le iʻuga e faʻaititia le mumu i le tino o le tagata. Immunomodulators ono faʻaititia le numera o ulcerative colitis flare-ups o ia te oe ma fesoasoani ia te oe e tumau ai faʻailoga-leai se umi.

Immunomodulator e masani ona faʻaaogaina i tagata o latou faʻailoga e le i puleaina ma aminosalicylates ma corticosteroids. Peitaʻi, o nei vailaʻau atonu e tele ni masina e amata galue ai.

Immunomodulators aofia ai:

Tocacitinib

Seʻia oʻo mai nei, e leʻi faʻamaonia e le US Food and Drug Administration (FDA) na faʻamaonia le puipuiga o le fale e togafitia ai tagata e maua i le ulcerative colitis. Ae ui i lea, o lenei vasega o vailaʻau sa o nisi taimi faʻaaogaina ese-igoa e togafitia ai tagata ma ulcerative colitis.

O se tasi o ia ituaiga igoa-faʻaaoga faʻaaoga na avea ma mea o le tuanaʻi i le 2018 ina ua faʻamaonia e le FDA le faʻaaogaina o se vailaʻau mo tagata e maua i le ulcerative colitis. O lenei immunomodulator e taʻua o le tofacitinib (Xeljanz). Na faʻamaonia muamua e le FDA mo tagata e maua ile rheumatoid arthritis ae na faʻaaoga le igoa ole igoa mo tagata e maua ile ulcerative colitis. Xeljanz o le muamua vailaʻau o lona ituaiga e tuʻuina atu i le gutu - nai lo le tuiina - mo se taimi umi togafitiga o tagata ma ulcerative colitis.

Aʻoaʻo atili e uiga i le faʻaaogaina o fualaau oona.

Methotrexate

E avanoa le Methotrexate o se laupapa e te tautala ai i lou gutu. E faʻapea foi ona tuʻuina mai e ala i le faʻaaogaina (IV) faʻasusuina faʻapea foi ma subcutaneous ma intramuscular tui. O loʻo avanoa le laupapa faʻapea o se vailaʻau masani ma o le igoa Trexall fualaʻau igoa. O le IV fofo ma tui intramuscular e naʻo avanoa e avea ma vailaʻau lautele. O le tui subcutaneous e naʻo avanoa o le igoa-igoa vailaʻau Otrexup ma Rasuvo.

Azathioprine

Mo togafitiga papala ulcerative colitis, azathioprine sau o se laulau e te ave i lou gutu. E avanoa e avea o se lautele vailaʻau ma pei o le igoa-igoa vailaʻau Azasan ma Imuran.

Merc laptopurine

Merc laptopurine o loʻo avanoa e pei o se laupapa poʻo se suavai faʻamalologa, uma ave e le gutu. O le laulau e faʻatoa avanoa e avea o se vailaʻau lautele, ma o le faʻamalologa e faʻatoa avanoa e avea o le igoa-igoa vailaʻau Purixan.

Aafiaga o le methotrexate, azathioprine, ma le merc laptopurine

O aʻafiaga masani a nei tagata puipuia e mafai ona aofia ai:

• tiga le ulu
• niniva
• puaʻi
• manava tata
• papala gutu
• lelava
• maualalo le toto sela

Faʻataʻitaʻiga o vailaʻau e mafai ona faʻafesoʻotaʻi e le tagata e aofia ai:

• allopurinol
• aminosalicylates pei o sulfasalazine, mesalamine, ma olsalazine
• angiotensin-liua mai o le enzyme (ACE) taofi e pei o lisinopril ma enalapril
• warfarin
• ribavirin
• nonsteroidal anti-inflammatory vailaʻau (NSAIDs) pei o naproxen ma ibuprofen
• phenylbutazone
• phenytoin
• sulfonamides
• probenecid
• retinoids
• theophylline

Biologics

Biologics o genetically fuafuaina vailaʻau fausiaina i totonu o le lab mai se ola tino. O nei vailaʻau puipuia nisi polotini i lou tino mai mafua pupuga. O vailaʻau o le biologic e faʻaogaina mo tagata e feololo ma papala i le papala. O loʻo faʻaaogaina foi mo tagata o latou faʻailoga e leʻo faʻatonutonuina ma togafitiga e pei ole aminosalicylates, immunomodulator, poʻo corticosteroids.

E lima vailaʻau biologic vailaʻau e faʻaogaina mo ulcerative colitis faʻailoga pulega. E naʻo avanoa ole igoa ole igoa, e aofia ai:

• adalimumab (Humira), na tuʻuina mai e le tui faʻapitoa
• golimumab (Simponi), na tuʻuina mai i le subcutaneous injection
• infliximab (Remicade), na tuʻuina mai e le IV infusion
• infliximab-dyyb (Inflectra), tuuina mai e IV infusion
• vedolizumab (Entyvio), na tuʻuina e le IV infusion

Oe ono manaʻomia le ave adalimumab, golimumab, infliximab, poʻo infliximab-dyyb e oʻo atu i le valu vaiaso ae e te leʻi vaʻaia se faʻaleleia atili. Vedolizumab masani lava ona amata galue i le ono vaiaso.

O aʻafiaga masani a fualaʻau faʻasaina e mafai ona aofia ai:

• tiga le ulu
• fiva
• malulu
• hives poʻo le mageso
• faʻateleina faʻamaʻi

O vailaʻau o le paiolo e mafai ona faʻafesoʻotaʻi ma isi sooupu o meaola. O faʻataʻitaʻiga o ia mea e aofia ai:

• natalizumab
• adalimumab
• golimumab
• infliximab
• anakinra
• abatacept
• tocilizumab
• warfarin
• cyclosporine
• theophylline
• ola tui e pei o le vailaʻau o le varicella zoster

Aloʻese mai NSAIDs

NSAIDs, pei ole ibuprofen ma naproxen, e masani ona faʻaititia le mumu ile tino. Afai e maua oe ile papala papala, ae ui i lea, o nei vailaʻau ono faʻalauteleina ai au faʻailoga. Ia mautinoa e te talanoa ma lau fomaʻi ae e te leʻi faia le NSAID.

Talanoa ma lau fomaʻi

Tele vailaʻau mafai ona fesoasoani faʻaititia lou ulcerative colitis faʻailoga. Afai e te maua i le papala papala, toe iloilo lenei tusitusiga ma lau fomaʻi ma talanoa e uiga i vailaʻau e ono talafeagai mo oe. O le a fautuaina e lau fomaʻi vailaʻau faʻavae i mea taua e pei o lou soifua maloloina lautele ma pe o le a le ogaoga o lou tulaga o.

Atonu e manaʻomia oe ona faʻataʻitaʻi ni nai vailaʻau ae e te leʻi mauaina se togafitiga togafitiga e aoga mo oe. Afai o le inuina o se vailaʻau e le faʻaititia ai au faʻailoga, e ono faʻaopopo e lau fomaʻi se vailaʻau lona lua e aoga ai le muamua. Atonu e umi se taimi, ae o le a galulue faʻafomaʻi lau fomaʻi e saili ni vailaʻau saʻo e fesoasoani e faʻamama ai lou faʻamaʻi papala papala.