Thrombotic Thrombocytopenic Purpura: O Le a Lenei, Mafuaʻaga ma Togafitiga

Anotusi

• Mafuaʻaga o le PTT
• Faailoga autu ma auga
• Faʻafefea ona faia le faʻamaoniga
• PTT Togafitiga

Thrombotic thrombositopenic purpura, poʻo le PTT, o se faʻamaʻi e seasea tupu ai ae o se faʻamaʻi oti e faʻailoaina e le fausiaina o tamaʻi thrombi i totonu o ala toto ma e taatele i tagata i le va o le 20 ma le 40 tausaga le matutua.

I le PTT o loʻo iai le paʻu maualalo ile numera o peleti, e faʻaopopo i le fiva ma, i le tele o tulaga, faʻaletonu ole neura ona o le suiga ole alu ole toto ile faiʻai ona ole faʻapipiʻi.

O le faʻamaoniga o le PTT na faia e le hematologist poʻo le general practitioner e tusa ai ma faʻailoga ma taunuʻuga o le atoa o le toto ma le toto palu ma le togafitiga e tatau ona vave amata mulimuli ane, ona o le faʻamaʻi e afaina i le tusa o le 95% pe a le togafitia.

Mafuaʻaga o le PTT

O le thrombotic thrombositopenic purpura e tele lava ina mafua mai i le le lava poʻo le fesuiaiga o gaʻo o se enzyme, ADAMTS 13, o le nafa ma le faia o molelaʻele o von Willebrand factor laʻititi, ma fiafia i la latou galuega. O le von Willebrand factor o loʻo iai i peleti ma e nafa ma le faʻalauiloaina ole faʻamaʻi pipisi ile faʻavae, faʻaititia ma taofia le tafe.

O le mea lea, i le toesea o le ADAMTS 13 enzyme, o le von Willebrand factor molemole e tumau pea tele ma o le toto totoʻa gaioiga e faʻaletonu ma e i ai le sili atu avanoa o faʻaputuputuga fausia.

O le mea lea, PTT ono i ai ni tupuaga mafuaʻaga, lea e tutusa ma ADAMTS 13 le lava, pe maua, o mea na e mafua ai le faʻaititia o le numera o peleti, e pei o le faʻaaogaina o immunosuppressive po chemotherapeutic vailaʻau poʻo antiplatelet sooupu, faʻamaʻi, meaʻai le lelei poʻo faʻamaʻi autoimmune, mo se faʻataʻitaʻiga.

Faailoga autu ma auga

E masani ona faʻaalia e le PTT faʻailoga le mautinoa, peitaʻi e masani lava mo tagata mamaʻi e iai le PTT masalomia e iai ni mea se 3:

1. Faailoga thrombocythemia;
2. Hemolytic anemia, talu mai le thrombi fausia fiafia le lysis o mumu sela toto;
3. Fiva;
4. Thrombosis, lea e mafai ona tupu i le tele o totoga o le tino;
5. Ogaoga tiga o le manava ona o ischemia manava;
6. Faʻaletonu fatugaʻo;
7. Faʻaleagaina neurological, lea e mafai ona iloa e ala i le tiga o le ulu, le mautonu le mafaufau, fia moe ma e oʻo foi ma le koma.

E taatele foi mo tagata mamaʻi e iai masalosaloga PTT e iai faʻailoga ole thrombositopenia, pei ole vaʻaia o 'ie lanu viole poʻo mūmū i luga ole paʻu, gaʻo toto pe ala ile isu, e faʻaopopoga ile faigata taofiofia ole toto ile tamaʻi manuʻa. Iloa isi faʻailoga o le thrombocytopenia.

Ole faʻaletonu ole fatu ma neura ole mea faigata tele ole PTT male tulaʻi mai pe a faʻalavelave le tamaʻi thrombi ile alu o le toto ile fatugaʻo ma le faiai, e mafua ai le faaletonu ole fatu ma faʻamaʻi, mo se faʻataʻitaʻiga. Ina ia aloese mai faʻalavelave, e taua tele pe a oʻo mai ni faʻailoga muamua, e faʻafesoʻotaʻi se fomaʻi lautele poʻo se hematologist ina ia mafai ai ona amataina le faʻamaʻi ma togafitiga.

Faʻafefea ona faia le faʻamaoniga

O le faʻamaoniga o le thrombotic thrombocytopenic purpura e faia faʻavae i luga o faʻailoga na faʻaalia e le tagata, i le faʻaopopoina i le iʻuga o le toto faitau, lea o loʻo faʻaititia ai le faʻaititia o le aofaʻi o platelets, ua faʻaigoaina o le thrombositopenia, e faʻaopoopo i le maitauina i le faʻaputuputuga palasi faʻaputuputuga, o le taimi e pipii faʻatasitasi pipii faʻatasi, i le faʻaopopoina i schizocytes, o vaega ia o mumu sela sela, aua o mumu sela sela pasi ala toto na poloka e tamaʻi vaʻa.

O isi suʻega e mafai foi ona okaina e fesoasoani ai i le suʻesuʻeina o le PTT, e pei o le taimi e alu ai le toto, ua faʻateleina, ma le toʻesea poʻo le faʻaititia o le enzyme ADAMTS 13, o se tasi o mafuaʻaga o le fausiaina o tamaʻi thrombi.

PTT Togafitiga

Togafitiga mo thrombotic thrombositopenic purpura e tatau ona amata i se taimi vave e mafai ai, ona e afaina ai i le tele o tulaga, talu ai o le fausiaina thrombi mafai ona poloka alatoto e oʻo atu i le faiʻai, faʻaititia le toto tafe i lena itulagi.

O le togafitiga masani faʻailoa mai e le hematologist o plasmapheresis, o se toto filtration gaioiga lea o le sili atu o vailaʻau e ono mafua ai lenei faʻamaʻi ma le sili atu o von Willebrand mea, faʻatasi ai ma le lagolago lagolago, pei o hemodialysis, faʻataʻitaʻiga. Faʻataʻitaʻiga. , pe a fai e faʻaleagaina fatugaʻo. Malamalama pe faʻafefea ona faia le plasmapheresis.

I se faʻaopopoga, o le faʻaaogaina o vailaʻau oona ma vailaʻau puipuia mo le puipuia o le tino, mo se faʻataʻitaʻiga, e ono fautuaina e le fomaʻi, ina ia mafai ai ona teteʻe i le mafuaʻaga o le PTT ma aloese mai faʻalavelave.