Acromegaly

Acromegaly o se tuutuuga e tele naua ai le tuputupu aʻe (GH) i le tino.

Acromegaly o se tulaga seasea. E mafua pe a fai o le pituitary gland faia tele tele tupu tupuola. O le pituitary gland o se tamaʻi toto endocrine faʻapipiʻi i le pito i lalo o le faiʻai. E faʻatonutonu, faia, ma faʻatuʻu ni isi homone, e aofia ai le tuputupu aʻe o le homone.

E masani lava o le tuma (benign) tumo o le pituitary gland faʻasaʻolotoina tele tele tuputupu ae homone. I ni tulaga e seasea tupu, o pituitary tumors e mafai ona mauaina.

I tamaiti, tele GH mafua ai gigantism nai lo acromegaly.

Faʻailoga o le acromegaly ono aofia ai soʻo se tasi o mea nei:

• Manogi o le tino
• Toto i le faʻataulaga
• Carpal auala faʻafafa
• Faʻaitiitia le malosi o le maso (vaivaiga)
• Faʻaitiitia le vaʻai lautele
• Faigofie vaivai
• Maualuga maualuga (pe a ova GH gaosiga amata i taimi o tamaititi)
• Ua afu tele
• Tigā ulu
• Faalauteleina fatu, lea e mafai ona mafua ai matapogia
• Aulelei
• Tiga o le auvae
• Tiga soʻoga, faʻatapulaʻa gaioiga soʻoga, fulafula o ponaivi vaega faataamilo i soʻoga
• Tele ponaivi o le mata, lapoa auvae ma le laulaufaiva, lautele nifo nifo
• O vae lapoʻa (sui ile seevae), lapopoʻa lima (sui i le mama poʻo le totini lima)
• Tele glands i le paʻu (sebaceous glands) mafua ai gaʻoa paʻu, mafiafia o le paʻu, paʻu pine (tuputupu aʻe)
• Ole moe ole moe
• Faalauteleina tamatamailima po o tamaivae, ma le fulafula, mumu, ma le tiga

Isi faʻailoga e ono tupu i lenei faʻamaʻi:

• Kolisi polyps
• Ova lauulu tuputupu ae i fafine (hirsutism)
• Toto maualuga
• Ituaiga 2 suka
• Faʻateleina o lou thyroid
• Faʻateleina le mamafa

O le a faʻatautaia e le fomaʻi le soifua maloloina se suʻega o le tino ma fesili e uiga i ou faʻailoga.

O faʻataʻitaʻiga nei e ono poloaʻia e faʻamaonia ai le faʻamaonia o le gasegase ma siaki mo faʻalavelave:

• Kulukose o le toto
• O le tuputupu ae o le homone ma le tuputupu aʻe o le homone tofotofoga taofiofi
• Insulin-pei o le tuputupu aʻe vaega 1 (IGF-1)
• Prolactin
• Spine x-ray
• MRI o le faiʻai, e aofia ai le pituitary gland
• Echocardiogram
• Kolone tetele
• Suesuega i le moe

O isi suʻega e ono okaina e siaki pe o totoe o le pituitary gland o loʻo galue masani.

O taotoga e aveese ai le pituitary tumo o loʻo mafua ai lenei tulaga e masani ona faʻasaʻo ai le le atoatoa GH. O isi taimi, o le tumo e lapoʻa tele e aveʻesea atoa ma e le faʻamaloloina le tino. I lenei tulaga, vailaʻau ma radiation (radiotherapy) ono faʻaaogaina e togafitia ai le gasegase o le tino.

O nisi tagata e iai tuma e faigata tele ona aveʻese ile taotoga e togafitia i vailaʻau ae le o se taotoga. O nei vailaʻau mafai ona poloka le gaosiga o le GH mai le pituitary gland pe puipuia le gaioiga o le GH i isi vaega o le tino.

A maeʻa togafitiga, e te manaʻomia le vaʻaia o lau tautua i taimi uma ina ia mautinoa o le pituitary gland o loʻo galue masani ma e le toe foʻi mai le kulimi. Fautuaina i tausaga taʻitasi.

O nei punaʻoa ono mafai ona maua mai nisi faʻamatalaga luga o le otootoga:

• National Institute of Diabetes ma Digestive ma Fatugaʻo Faʻamaʻi - www.niddk.nih.gov/health-information/endocrine-diseases/acromegaly
• National Organisation for Rare Disorder - rarediseases.org/rare-diseases/acromegaly

Ole taotoga pituitary e manuia ile tele o tagata, faʻamoemoe ile tele ole tumo male poto masani ole neurosurgeon ma pituitary tumors.

A aunoa ma togafitiga, o le a sili atu le leaga faʻailoga. Tulaga e pei o le toto maualuga, maʻi suka, ma faʻamaʻi fatu e ono iʻu.

Valaʻau lau tautua pe a fai:

• E i ai a faʻailoga o le gasegase
• O au faʻailoga e le faʻaleleia atili i togafitiga

Acromegaly le mafai ona puipuia. O le vave togafitia e ono puipuia ai le faʻamaʻi mai le leaga atili ma fesoasoani e aloese mai faʻalavelave.

Somatotroph adenoma; Faʻatuputeleina o le homone; O le tuputupu aʻe o le homone lilo i le pituitary adenoma; Pituitary giant (i le taimi o tamaiti)

• Laʻau Endocrine

Katznelson L, Laws ER Jr, Melmed S, et al. Acromegaly: o le endocrine sosaiete falemaʻi faʻataʻitaʻiina taʻiala. J Clin Endocrinol Metab. 2014; 99 (11): 3933-3951. PMID: 25356808 www.ncbi.nlm.nih.gov/pubmed/25356808.

Klein I. Endocrine faʻafitauli ma faʻamaʻi fatu fatu. I totonu: Mann DL, Zipes DP, Libby P, Bonow RO, Braunwald E, eds. Braunwald's Heart Disease: O Se Tusitusiga o Faʻafomaʻi Cardiovascular. 10 ed. Filatelefaia, PA: Elsevier Saunders; 2015: mata 81.

Melmed S. Acromegaly. I totonu: Jameson JL, De Groot LJ, de Kretser DM, et al, eds. Endocrinology: Matutua ma Tamaiti. 7th ed. Filatelefaia, PA: Elsevier Saunders; 2016: mata 12.