Carcinoid syndrome

Carcinoid syndrome o se kulupu o faʻailoga e fesoʻotaʻi ma tuma o le carcinoid. Nei o ponaivi o le manava laʻitiiti, kolone, faʻaopoopoga, ma faʻamaʻamaʻamaʻi i totonu o mama.

Carcinoid syndrome o le faʻataʻitaʻiga o faʻailoga i nisi taimi e vaʻaia i tagata e maua i le kanesa ole carcinoid. O nei tuma e seasea maua, ma e masani ona faifai lemu. Tele carcinoid tumors e maua i le gastrointestinal tract ma mama.

O le Carcinoid syndrome e tupu i nai tagata e maua i le kanesa o le carcinoid, pe a uma ona sosolo le tuma i le ate poʻo le mama.

O nei tumors faʻasaʻolotoina tele o le homone serotonin, faʻapea foi ma le tele o isi vailaʻau. O homone e mafua ai ona matala (faʻalautele) vaʻa toto. Lenei mafua ai carcinoid syndrome.

O le carcinoid syndrome e faia i luga o le fa auga faʻailoga aofia ai:

• Fagu (foliga, ua, poʻo le pusa i luga), e pei o le faʻalauteleina o le toto vaʻaia vaʻaia luga o le paʻu (telangiectasias)
• Faigata manava, e pei o le vevela
• Manava tata
• O faʻafitauli o le fatu, e pei o le paʻu o afu o le fatu, lemu le tata o le fatu, maualalo pe maualuga le toto

O auga e maua i nisi taimi e ala i le faʻamalosi tino, poʻo le 'ai poʻo le inuina o mea e pei o sisi lanumoana, sukalati, po o le uaina mumu.

Ole tele o nei tuma e maua pe a fai ni suʻega poʻo ni auala e faia ai mo isi mafuaʻaga, pei o taimi o taotoga o le manava.

Afai ua maeʻa se suʻega faʻaletino, e ono maua e le tausi soifua maloloina faʻailoga o:

• Faʻafitauli ole alatoto ole fatu, pei ole muimui
• Niacin-deficit faamaʻi (pellagra)

O suʻega e mafai ona faia e aofia ai:

• 5-HIAA tulaga i miaga
• Toto suʻega (aofia ai serotonin ma chromogranin toto suʻega)
• CT ma le MRI faʻataʻitaʻi le fatafata poʻo le manava
• Echocardiogram
• Oketopaide faʻasolosolo faʻasolitulafono faʻataʻitaʻi

O taotoga e aveese ai le tuma o le muamua togafitiga. E mafai ona faʻamaloloina tumau le tulaga pe a fai o le tumo ua aveʻesea atoa.

Afai ua sosolo le tumo i le ate, togafitiga aofia ai se tasi o mea nei:

• Aveʻesea o vaega ole ate o loʻo i ai sela tuma
• Auina atu (infusing) vailaʻau tuusao i le ate e faʻaleagaina le patu

A le mafai ona aveʻesea le tumo atoa, o le aveʻese o vaega tele o le tumo ("debulking") e mafai ona fesoasoani e faʻamalolo ai faʻailoga.

Octreotide (Sandostatin) poʻo le lanreotide (Somatuline) tui e tuʻuina atu i tagata o loʻo maua ai ni tuma o le carcinoid e le mafai ona aveʻesea ile taotoga.

Tagata e maua ile carcinoid syndrome e tatau ona 'aloʻalo i le' ava malosi, 'aiga tele, ma meaʻai e tele i le tyramine (cheeses matua, avoka, tele meaʻai gaosi), aua e ono faʻaosofia ai faʻailoga.

O vailaʻau masani, pei o le filifilia o le serotonin reuptake inhibitors (SSRIs), pei o le paroxetine (Paxil) ma le fluoxetine (Prozac), e ono atili ai ona leaga faʻailoga e ala ile faʻateleina ole maualuga ole serotonin. Peitai, AUA le taofia le inuina o nei vailaʻau seʻi vagana ua taʻu atu ia te oe e lau tautua.

Aʻoaʻo atili e uiga ile carcinoid syndrome ma maua le lagolago mai:

• Le Carcinoid Cancer Foundation - www.carcinoid.org/resource/support-groups/directory/
• Neuroendocrine Tumor Research Foundation - netrf.org/for-patients/

O le vaʻai i tagata e maua i le carcinoid syndrome e ese ai i isi taimi ma le vaʻai a tagata e maua i le kanesa o le tino e aunoa ma le faʻamaʻi.

Prognosis faʻamoemoeina foi i luga o le nofoaga o le tumo. I tagata e maua i le faʻamaʻi, o le tumo e masani ona sosolo i le ate. Lenei tuʻuina i lalo le ola fua. Tagata e maua ile carcinoid syndrome e ono maua foʻi ile kanesa ese (lona lua tuma muamua) ile taimi e tasi. I le aotelega, o le vavalo e masani ona sili atu ona lelei.

Faʻafitauli o le carcinoid syndrome mafai ona aofia ai:

• Faateleina le lamatiaga o le pa'ū ma manuʻa (mai le maualalo o le toto)
• Faʻafitauli o le manava (mai le tumo)
• Tapa ole gastrointestinal
• Ua faaletonu le alatoto o le fatu

O se tulaga matautia o le carcinoid syndrome, carcinoid crisis, e ono tupu mai o se itu o le taotoga, vai faagase poʻo le chemotherapy.

Faʻafesoʻotaʻi lau tautua mo se taimi pe a fai oe maua faʻailoga o le carcinoid syndrome.

Ole togafitia ole tumo e faʻaititia ai le aʻafiaga ole carcinoid syndrome.

Faigama toto; Argentaffinoma syndrome

• Serotonin aveina

'Upega Tafaʻilagi a le National Cancer Institute. Gastrointestinal carcinoid tumors togafitiga (Matutua) (PDQ) - soifua maloloina polofesa lomiga. www.cancer.gov/types/gi-carcinoid-tumors/hp/gi-carcinoid-treatment-pdq. Faʻafou Setema 16, 2020. Avanoa ia Oketopa 14, 2020.

Öberg K. Neuroendocrine tumors ma faʻafitauli fesoʻotaʻi. I: Melmed S, Auchus, RJ, Goldfine AB, Koenig RJ, Rosen CJ, eds. Williams Tusitusiga o Endocrinology. 14th lomiga. Filatelefia, PA: Elsevier; 2020: chap 45.

Wolin EM, Jensen RT. Tumua Neuroendocrine. I totonu: Goldman L, Schafer AI, eds. Faʻafomaʻi Goldman-Cecil. 26th lomiga. Filatelefia, PA: Elsevier; 2020: mata 219