Neuropathy lona lua i vailaʻau

Neuropathy o se manuʻa i neula peripheral. O neula ia e leʻo iai i le faiʻai poʻo le uaula. Neuropathy lona lua i vailaʻau o se leiloa o lagona poʻo gaioiga i se vaega o le tino ona o neula faʻaleagaina mai le aveina o se faapitoa vailaʻau poʻo tuʻufaʻatasia o vailaʻau.

O le faʻaletonu e mafua mai i le oʻona aʻafiaga o nisi vailaʻau i luga o neula peripheral. E i ai le faʻaleagaina o le vaega axon o le neula sela, lea faʻalavelave i neula faailo. Poʻo le, mea faʻaleagaina e ono aofia ai le myelin sheath, lea e faʻatosina ai au ma faʻateleina le saoasaoa o le faʻailoaina o faʻailo e ala i le axon.

Tele masani, tele neura e aofia ai (polyneuropathy). Lenei masani ai mafua sensation suiga e amata i fafo vaega o le tino (distal) ma agai agai i le ogatotonu o le tino (vavalalata). E i ai foi suiga i gaioiga, pei o vaivaiga. Atonu foi e iai le tiga mumu.

Tele vailaʻau ma vailaʻau ono mafua ai le atinaʻeina o le neuropathy. O loʻo lisi atu i lalo faʻataʻitaʻiga.

Loto poʻo le toto maualuga fualaʻau:

• Amiodarone
• Hydralazine
• Perhexiline

Fualaʻau masani e tau ai le kanesa:

• Cisplatin
• Docetaxel
• Paclitaxel
• Suramin
• Vincristine

Fualaʻau sa masani ona tau ai faʻamaʻi:

• Chloroquine
• Dapsone
• Isoniazid (INH), faʻaaoga faʻasaga i le fatafata
• Metronidazole (Flagyl)
• Nitrofurantoin
• Thalidomide (faʻaaoga e tau ai le lepela)

Fualaʻau na faʻaaoga e togafitia ai faʻamaʻi autoimmune:

• Etanercept (Enbrel)
• Infliximab (Remicade)
• Leflunomide (Arava)

Fualaʻau faʻaaogaina e togafitia ai le faʻamaʻi:

• Carbamazepine
• Phenytoin
• Phenobarbital

Fualaʻau faʻasaina i le 'ava malosi:

• Disulfiram

Fualaʻau e tau ai le HIV / AIDS:

• Didanosine (Videx)
• Emtricitabine (Emtriva)
  
• Stavudine (Zerit)
• Tenofovir ma emtricitabine (Truvada)

Isi vailaʻau ma vailaʻau e ono mafua ai neuropathy aofia ai:

• Colchisin (faʻaaogaina e togafitia ai le gout)
• Disulfiram (faʻaaoga e togafitia ai le faʻaaogaina o le 'ava malosi)
• Arsenic
• Auro

Faʻailoga mafai ono aofia ai soʻo se tasi o mea nei:

• Leai se mea, leai se lagona
• Ootia, lagona le masani ai
• Vaivaiga
• Paʻu mu

O suiga lagona e masani lava ona amata i vae poʻo lima ma agaʻi i totonu.

O le faia o le faiai ma neula faiga suʻesuʻega o le a faia.

O isi suʻega e aofia ai:

• Toto suʻega e siaki tulaga o vailaʻau (e oʻo lava ile tulaga masani ole toto o nisi vailaʻau ono afaina ai i tagata matutua poʻo nisi tagata)
• EMG (electromyography) ma neura faʻataʻitaʻi faʻataʻitaʻiga o le eletise gaioiga o neula ma maso

Togafitiga faʻavae i luga o faʻailoga ma pe o le a le o latou ogaoga. O le vailaʻau na mafua ai le neuropathy ono taofi, faʻaititia i le inumaga, pe suia i se isi vailaʻau. (Aua neʻi suia se vailaʻau e aunoa ma le talanoa muamua i lau fomaʻi.)

E ono fautuaina e lau tautua nei vailaʻau nei e fesoasoani e taofiofia le tiga:

• O le faʻamamaina o le tiga e mafai ona fesoasoani mo le tiga (neuralgia).
• Phenytoin, carbamazepine, gabapentin, pregabalin, duloxetine, poʻo le tricyclic antidepressants pei o le nortriptyline e ono faʻaititia ai le tuia tiga o nisi tagata iloa.
• Opiate tiga fesoasoani, pei o le morphine poʻo le fentanyl, atonu e manaʻomia e faʻatonutonu tiga tiga.

E leai ni vailaʻau i le taimi nei e mafai ona toe fesuiaʻi le leiloa o lagona. Afai ua leiloa lagona, oe ono manaʻomia le faia o le saogalemu auala e aloese ai mai le manua.

Fesili i lau tautua pe a iai ni faʻamalositino e mafai ona fesoasoani e faʻamalolo ai au faʻailoga.

Tele o tagata e mafai ona faʻafuaseʻi pe toe foʻi ia latou galuega masani. O le faʻamaʻi e le masani ona mafua ai ni faʻafitauli tau faʻamataʻu i le ola, ae mafai ona avea ma se le toʻafilemu poʻo le le mafai.

Faʻafitauli e ono aofia ai:

• Le mafai ona galue i le galuega poʻo le fale ona o le tumau leiloa o lagona
• Paʻu ma tingling i le eria o neura manua
• Tumau leiloa o lagona (pe seasea, gaioi) i se eria

Valaʻau lau tautua pe a fai ua e leiloa lagona poʻo gaioi o soʻo se vaega o le tino a o inuina ni vailaʻau.

O lau kamupani o le a vaʻavaʻaia lelei lau togafitiga ma soʻo se vailaʻau e ono mafua ai le neuropathy. O le sini ia tausisia le toto lelei o le vailaʻau e manaʻomia e faʻatonutonu ai faʻamaʻi ma ona faʻailoga aʻo taofia le vailaʻau mai le oʻo i tulaga oona.

• Nofoʻaga popolevale ma faiga lautele neula

Jones MR, Urits I, Wolf J, et al. Fualaʻau-faʻaosoina peripheral neuropathy, o se faʻamatalaga iloiloina. Curr Clin Pharmacol. Ianuari 2019. PMID: 30666914 www.ncbi.nlm.nih.gov/pubmed/30666914.

Katirji B. Faʻaletonu o neula lautele. I totonu: Daroff RB, Jankovic J, Mazziotta JC, Pomeroy SL, eds. Bradley's Neurology i Fomaʻi Faʻataʻitaʻi. 7th ed. Filatelefia, PA: Elsevier; 2016: mata 107.

O'Connor KDJ, Mastaglia FL. Faʻaletonu-faʻatupuina faʻaletonu o le neula. I: Aminoff MJ, Josephson SA, eds. Aminoff's Neurology ma Faʻafomai Aoao. 5th ed. Waltham, MA: Elsevier Academic Press; 2014: mata 32.