Ovarian overproduction o androgens

Ovarian overproduction o androgens o se tuutuuga e faia ai e ovaries le tele o testosterone. Lenei mafua ai le atinaʻeina o tama tane uiga i se fafine. Androgens mai isi vaega o le tino mafai foi mafua ai tane uiga e atiina ae i fafine.

I fafine maloloina, o ovaries ma adrenal glands gaosia e tusa o le 40% i le 50% o le tino testosterone. Tumors o le ovaries ma polycystic ovary syndrome (PCOS) mafai uma mafua ai tele tele androgen gaosia.

Cushing faamaʻi o se faafitauli i le pituitary gland e tau atu i le sili atu aofaiga o corticosteroids. O Corticosteroids e mafua ai suiga o le tino tane i fafine. Tumors i le adrenal glands mafai foi mafuaʻaga tele gaosia o androgens ma mafai ona taitai atu ai i le tane tino uiga i fafine.

Maualuga tulaga o androgens i se fafine mafai mafua:

• Fuafua
• Suiga i foliga fafine foliga
• Faʻaitiitia i le fatafata tele
• Faʻateleina lauulu lauulu i se tama tane mamanu, pei o luga o foliga, auvae, ma manava
• Le lava o taimi masina (amenorrhea)
• Paʻu suauʻu

O nei suiga e ono tupu foi:

• Faʻateleina le tele o le clitoris
• Faʻalolotoina o le leo
• Faʻateleina le maso maso
• O le manifinifi o lauulu ma lauulu leiloa i luma o le ulu i itu uma o le ulu

O lau fomaʻi tausi soifua o le a faia se faʻamalositino suʻega. Soʻo se toto ma faʻataʻitaʻiga faʻataʻitaʻiga faʻatonuga o le a faʻamoemoe i ou faʻailoga, ae mafai ona aofia ai:

• 17-hydroxyprogesterone suʻega
• Suʻega a le ACTH (e le masani ai)
• Suʻega ole toto Cholesterol
• CT faʻasolosolo
• Suʻega ole toto ole DHEA
• Suʻesuʻega ole kulukose
• Suʻega o le inisalini
• Pelvic ultrasound
• Faʻataʻitaʻiga ole Prolactin (pe a oʻo mai taimi e seasea tupu ai pe leai uma)
• Tofotofoga testosterone (uma maua fua ma le aofaʻi testosterone)
• TSH suʻega (pe a fai e paʻu lauulu)

Togafitiga faʻalagolago i le faʻafitauli ua mafua ai le faateleina androgen gaosia. O vailaʻau e mafai ona tuʻuina atu e faʻaititia ai le gaosiga o lauulu i fafine e sili atu le paʻu o le tino, pe faʻatonutonu le taamilosaga. I nisi tulaga, o taotoga ono manaʻomia e aveʻese ai le ovarian poʻo le adrenal tumo.

Togafitiga manuia faalagolago i le mafuaaga o le sili atu androgen gaosiga. Afai o le tulaga e mafua mai i se tuma ovarian, taotoga e aveese le tumo atonu faasaʻo le faafitauli. Ole tele ole tuma ole laʻau e le o kanesa (lelei) ma o le a le toe foʻi mai peʻa uma ona aveʻesea.

I le polycystic ovary syndrome, o mea nei e mafai ona faʻaititia ai faʻailoga e mafua mai i le maualuga o le androgen level:

• Mataitu ma le totoʻa
• Paʻu pauna
• Suiga o taumafataga
• O vailaʻau
• Faamalositino malosi masani

Le faʻamalositino ma faʻafitauli i taimi o maʻito e ono tupu.

Tamaʻitaʻi e maua i le polycystic ovary syndrome e ono tupu tele le lamatiaga mo:

• Maʻi suka
• Toto maualuga
• Kolisi maualuga
• Puta tele
• Kanesa o le faiʻai

Tamaʻitaʻi e maua i le polycystic ovary syndrome mafai ona faʻaititia a latou suiga o faʻafitauli i se taimi umi e ala i le faʻatumauina o le mamafa masani e ala i meaʻai maloloina ma faʻamalositino masani.

• Ova ovasia
• Follicle atinae

Bulun SE Physiology ma faʻamaoniga o le fafine fanautama au. I: Melmed S, Auchus RJ, Goldfine AB, Koenig RJ, Rosen CJ, eds. Williams Tusitusiga o Endocrinology. 14th lomiga. Filatelefia, PA: Elsevier; 2020: chap 17.

Huddleston HG, Quinn M, Gibson M. Polycystic ovary syndrome ma hirsutism. I le: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Nelson Tusitusiga o Pediatrics. 21 ed. Filatelefia, PA: Elsevier; 2020: chap 567.

Lobo RA. Hyperandrogenism ma androgen sili atu: physiology, etiology, eseʻesega faʻamaoniga, pulega. I: Lobo RA, Gershenson DM, Lentz GM, Valea FA, eds. Faʻapitoa Gynecology. 7th ed. Filatelefia, PA: Elsevier; 2017: chap 40.

Rosenfield RL, Barnes RB, Ehrmann DA. Hyperandrogenism, hirsutism, ma polycystic ovary syndrome. I totonu: Jameson JL, De Groot LJ, de Kretser DM, et al, eds. Endocrinology: Matutua ma Tamaiti. 7th ed. Filatelefaia, PA: Elsevier Saunders; 2016: mata 133.