Suʻega ole Glucose-6-phosphate dehydrogenase

Glucose-6-phosphate dehydrogenase (G6PD) o se polotini e fesoasoani i sela mumu toto e galulue faʻalelei. O le suʻega G6PD e vaʻai i le aofaʻi (gaioiga) o lenei vailaʻau i sela mumu toto.

E manaʻomia se faʻataʻitaʻiga ole toto.

E leai se sauniuniga faʻapitoa e masani ona manaʻomia.

A faʻaofi le nila e toso le toto, o nisi tagata e lagona le feololo tiga. O isi e naʻo se tuitui poʻo se tui e lagona. A maeʻa, atonu e i ai se tuitui poʻo sina manuʻa. Lenei vave alu ese.

E ono fautuaina e lau tausi soifua maloloina lenei suʻega pe a fai o iai sau faʻailoga o le G6PD le atoatoa. O lona uiga e le lava au G6PD gaioiga.

Laʻititi G6PD gaioiga e tau atu i le faʻaleagaina o mumu toto sela. O lenei faiga e taʻua ole hemolysis. Afai o lenei gaioiga o loʻo tupu malosi, e taʻua o le hemolytic vaega.

E mafai ona faʻaosoina ni vaega o le hemolytic e faʻamaʻi pipisi, nisi o meaʻai (pei o pi fava), ma nisi vailaʻau, e aofia ai:

• Fualaʻau na faʻaaoga e faʻaititia ai le fiva
• Nitrofurantoin
• Phenacetin
• Primaquine
• Sulfonamides
• Thiazide diuretics
• Tolbutamide
• Quinidine

E masani ona fesuiaʻi ma faʻalagolago i le fale suʻesuʻe na faʻaaogaina. O nisi fale suesue faʻaaoga eseese fuataga pe tofotofoina eseese faʻataʻitaʻiga. Talanoa i lau tautua e uiga i le uiga o au faʻapitoa suʻega iʻuga.

O faʻaiuga masani o lona uiga e iai sou faaletonu ile G6PD. Lenei mafai mafua ai hemolytic anemia i nisi tulaga.

E i ai laʻititi se aʻafiaga e ono aafia ai i lou aveina o lou toto. O uaua ma alatoto e eseese i le tele mai le tasi tagata i le isi ma mai le tasi itu o le tino i le isi. Mauaina o se toto faʻataʻitaʻiga mai nisi tagata ono faigata sili atu nai lo isi.

O isi faʻafitauli e fesoʻotaʻi ma le tosoina o le toto e laʻititi, ae mafai ona aofia ai:

• Toto tele
• Faaseʻe pe lagona le mumu o le ulu
• Tele tui e suʻe ai uaua
• Hematoma (faʻaputuputu toto i lalo o le paʻu)
• Faamaʻi (o se laʻititi tulaga lamatia soʻo se taimi le paʻu ua paʻu)

RBC G6PD suʻega; Lau G6PD

Chernecky CC, Berger BJ. Glucose-6-phosphate dehydrogenase (G6PD, G-6-PD), aofaʻi - toto. I le: Chernecky CC, Berger BJ, eds. Suʻesuʻega a le Falesuesue ma Taualumaga o Suʻesuʻega. 6th ed. St Louis, MO: Elsevier Saunders; 2013: 594-595.

Gallagher PG. Hemolytic anemias: mumu toto mumu membrane ma faaletonu metabolic. I totonu: Goldman L, Schafer AI, eds. Faʻafomaʻi Goldman-Cecil. 26th lomiga. Filatelefia, PA: Elsevier; 2020: chap152.