Tofotofoga Alpha-Fetoprotein (AFP)
Anotusi
- O le a le suʻega ole alpha-fetoprotein (AFP)?
- O le a le mea e faʻaaoga ai?
- Aisea ou te manaʻomia ai se suʻega a le AFP?
- Ole a le mea e tupu ile taimi ole suʻega ole AFP?
- Mata e tatau ona ou faia se mea e sauniuni ai mo le suʻega?
- E i ai ni lamatiaga i le suʻega?
- O le a le uiga o faʻaiuga?
- E iai se isi mea e tatau ona ou iloa e uiga ile suʻega ole AFP?
- Faʻamatalaga
O le a le suʻega ole alpha-fetoprotein (AFP)?
Alpha-fetoprotein (AFP) o se polotini gaosia i le ate o se tuputupu aʻe fetus. I le taimi o le tuputupu aʻe o se pepe, o nisi AFP e ui atu i le placenta ma alu atu i le toto o le tina. O le suʻesuʻega a le AFP e fua ai le tulaga o le AFP i fafine maʻitaga i le vaitaimi o le lua masina o le maitaga. O le tele poʻo le laʻititi o le AFP ile toto ole tina e ono avea ma faʻailoga ole faaletama fanau mai poʻo isi tulaga. E aofia ai:
- O le neural tube defect, o se tulaga ogaoga e mafua ai le le lelei atinaʻe o le tuputupu aʻe o le faiʻai o le pepe ma / poʻo le tuasivi
- Down syndrome, o se faʻamaʻi o le kenera e mafua ai le le atoatoa lelei o le mafaufau ma le tuai atinaeina
- Masaga poʻo le tele o fananau mai, aua e sili atu ma le tasi pepe o loʻo faʻatupuina le AFP
- Faʻasologa sese o le aso atofaina, ona ua suia le tulaga o le AFP i le taimi o le maʻito
Isi igoa: AFP Maternal; Serum Serum AFP; lau msAFP
O le a le mea e faʻaaoga ai?
O le suʻesuʻega o le toto o le AFP e faʻaalu e siaki ai le fetus o loʻo tupu aʻe mo ni tulaga le lelei o le fanau mai ma ni faʻafitauli o le gafa, pei o neural tube defect poʻo Down syndrome.
Aisea ou te manaʻomia ai se suʻega a le AFP?
O le American Pregnancy Association fai mai o fafine maʻitaga uma e tatau ona ofoina atu se suʻega a le AFP i se taimi i le va o le 15th ma le 20 vaiaso o le maitaga. Atonu e fautuaina faapitoa le suʻega pe a fai o oe:
- Fai se aiga talaʻaga o le fanau mai faaletonu
- E 35 tausaga pe sili atu
- Maʻi suka
Ole a le mea e tupu ile taimi ole suʻega ole AFP?
O le polofesa mo le soifua maloloina o le a ave se toto faʻataʻitaʻiga mai se uaua i lou lima, faʻaaoga ai se tamaʻi nila. A maeʻa ona tuʻu i totonu le nila, o le a faʻaputuputuina se vaega laʻititi o le toto i totonu o se faʻamaoniga poʻo se ipu. Atonu e te lagonaina sina tiga pe a alu le nila i totonu pe fafo. Lenei masani ona alu ifo i lalo o le lima minute.
Mata e tatau ona ou faia se mea e sauniuni ai mo le suʻega?
E te le manaʻomia ni sauniuniga faʻapitoa mo se suʻega a le AFP.
E i ai ni lamatiaga i le suʻega?
E laʻititi lava se faʻafitauli e ono tupu ia te oe poʻo lau pepe i le suʻega toto i le AFP. E i ai sina tiga poʻo se tiga i le mea na tuu ai le nila, ae o le tele o faʻailoga e vave ona alu ese. O le isi suʻega e taʻua o le amniocentesis e maua ai se faʻamatalaga saʻo o Down syndrome ma isi faaletonu o le fananau mai, ae o le suʻega e laʻititi lava le faʻafitauli e ono mafua ai se maʻitaga.
O le a le uiga o faʻaiuga?
Afai o au faʻaiuga faʻaalia maualuga atu nai lo tulaga masani a le AFP, atonu o lona uiga o lau pepe ua i ai se neural tube defect pei o le spina bifida, o se tulaga e le latalata ai ponaivi o le tuasivi faataamilo i le tuasivi, po o le anencephaly, o se tulaga e e le tupu lelei le faiʻai.
Afai o au faʻaiuga faʻaali maualalo ifo nai lo tulaga masani a le AFP, atonu o lona uiga o lau pepe ua maua i se maʻi faʻamaʻi e pei o Down syndrome, o se tulaga e mafua ai faʻafitauli tau le atamai ma le tuputupu aʻe.
Afai e le masani ai lau tulaga o le AFP, e le faʻapea e i ai se faʻafitauli ma lau pepe. Atonu o lona uiga ua sili atu ma le tasi lau pepe pe ua sese lau aso faʻatulagaina. Oe ono maua foi se iʻuga sese-lelei. Lona uiga o au faʻaiuga e faʻaalia ai se faʻafitauli, ae o lau pepe e maloloina. Afai o au faʻaiuga faʻaalia se maualuga atu pe maualalo ifo nai lo le tulaga masani o le AFP, oe ono ono maua le tele o suʻega e fesoasoani ai faia se faʻamaoniga.
Aʻoaʻo atili e uiga i suʻesuʻega falesuesue, vaitau o faʻasino, ma malamalamaaga i iʻuga
E iai se isi mea e tatau ona ou iloa e uiga ile suʻega ole AFP?
O suʻesuʻega a le AFP e masani ona avea ma vaega ole suʻega ole prenatal e taʻua ole tele marker poʻo le triple screen. I se faʻaopopoga i le AFP, o le faʻatolu suʻega o suʻega e aofia ai suʻega mo le hCG, o le homone na gaosia e le placenta, ma le estriol, o se ituaiga o estrogen na faia e le pepe. O nei suʻega e mafai ona fesoasoani e faʻailoaina Down syndrome ma isi faʻafitauli o le gafa.
A faʻapea e maualuga atu lou faʻafitauli i le iai o se pepe e iai ni faaletonu o lona fanau mai, e ono fautuaina foi e lau tautua se suʻega fou e taʻua ole cell-free DNA (CFDNA). Ole suʻega ile toto lea e mafai ona faia ile amataga o le 10th vaiaso o le maitaga. E mafai ona faʻaalia e mafai ona faʻaalia pe a iai i lau pepe se avanoa maualuga e maua ai i le Down syndrome poʻo nisi faʻalavelave tau kenera.
Faʻamatalaga
- American Pregnancy Association [Initaneti]. Irving (TX): American Pregnancy Association; c2017. Maternal Serum Alpha-Fetoprotein Screening (MSAFP) [faafouina 2016 Sep 2; taʻua 2017 Jun 5]; [pe tusa ma le 3 pupuni] Avanoa mai: http://americanpregnancy.org/prenatal-testing/maternal-serum-alpha-fetoprotein-screening
- American Pregnancy Association [Initaneti]. Irving (TX): American Pregnancy Association; c2017. Triple Screen Test [faʻafouina 2016 Sep 2; taʻua 2017 Jun 5]; [pe tusa ma le 3 pupuni] Avanoa mai: http://americanpregnancy.org/prenatal-testing/triple-screen-test/
- Tuugamau JC, Miller KE, Tagata Faʻatau AD. Suʻesuʻega ole Triple Analyte a le Maternal Serum i le Maitaga. Am Fam Doctor [Initaneti]. 2002 Mati 1 [taʻua 2017 Jun 5]; 65 (5): 915–921. Avanoa mai: https://www.aafp.org/afp/2002/0301/p915.html
- Johns Hopkins Faʻafomaʻi [Initaneti]. Johns Hopkins Faʻafomai; Faletusi a le Soifua Maloloina: Tofotofoga masani i le taimi o le Maitaga [taʻua 2017 Jun 5]; [pe tusa ma le 3 pupuni] Avanoa mai: http://www.hopkinsmedisin.org/healthlibrary/conditions/adult/pregnancy_and_childbirth/common_tests_during_pregnancy_85,p01241
- Lab Tofotofoga lugalaina [Initaneti]. Washington D.C .: American Association mo Vailaʻau Togafitiga; c2001–2019. Suʻesuʻeina o le Serum Maternal, Second Trimester; [faʻafouina 2019 Me 6; taʻua le 2019 Jun 4]; [pe a ma le 2 pupuni] Avanoa mai: https://labtestsonline.org/tests/maternal-serum-screening-second-trimester
- Lab Tofotofoga lugalaina [Initaneti]. American Association mo vailaʻau Togafitiga; c2001–2017. Glossary: Spina Bifida [taʻua 2017 Jun 5]; [pe tusa ma le 3 pupuni] Avanoa mai: https://labtestsonline.org/glossary/spina-bifida
- Merck Manual Consumer Version [Initaneti]. Kenilworth (NJ): Merck & Co. Inc. c2017. Suʻega Suʻega ole Prenatal Diagnostic [faʻafouina 2017 Jun; taʻua le 2019 Iuni 4]; [pe tusa ma le 3 pupuni] Avanoa mai: http://www.merckmanuals.com/home/women-s-health-issues/detection-of-genetic-disorder/prenatal-diagnostic-testing
- Nofoaga Tutotonu a le Atunuʻu mo le Faʻalauteleina o Faʻaliliuga Faʻasaienisi / Genetic and Rare Diseases Information Center [Initaneti]. Gaithersburg (MD): U.S. Matagaluega o le Soifua Maloloina ma Tagata Auaunaga; Neural Tube Defects [faʻafouina 2013 Nov 6; taʻua 2017 Jun 5]; [pe tusa ma le 3 pupuni] Avanoa mai: https://rarediseases.info.nih.gov/diseases/4016/neural-tube-defects
- National Heart, Lung, and Blood Institute [Initaneti]. Bethesda (MD): U.S. Matagaluega o le Soifua Maloloina ma Tagata Auaunaga; O a ni lamatiaga o le Toto? [faafou 2012 Jan 6; taʻua 2017 Jun 5]; [pe a ma le 5 pupuni] Avanoa mai: https://www.nhlbi.nih.gov/health-topics/blood-tests#Risk-Factors
- National Heart, Lung, and Blood Institute [Initaneti]. Bethesda (MD): U.S. Matagaluega o le Soifua Maloloina ma Tagata Auaunaga; Le Mea e Faʻamoemoeina ma Toto Tofotofoga [faʻafouina 2012 Ian 6; taʻua 2017 Jun 5]; [tusa o le 4 pupuni] Avanoa mai: https://www.nhlbi.nih.gov/health-topics/blood-tests
- Iunivesite o Rochester Medical Center [Initaneti]. Rochester (NY): Iunivesite o Rochester Medical Center; c2017. Health Encyclopedia: Alpha-fetoprotein (AFP) [taʻua 2017 Jun 5]; [pe a ma le 2 pupuni] Avanoa mai: https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=90&contentid;=P02426
- Iunivesite o Rochester Medical Center [Initaneti]. Rochester (NY): Iunivesite o Rochester Medical Center; c2017. Health Encyclopedia: Alpha-fetoprotein (Toto) [taʻua 2017 Jun 5]; [pe a ma le 2 pupuni] Avanoa mai: https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=167&contentid;=alpha_fetoprotein_maternal_blood
- UW Soifua Maloloina [Initaneti]. Madison (WI): Iunivesite o Wisconsin Falemai ma Falemai Pulega; c2017. Faʻamatalaga o le Soifua Maloloina: Alpha-Fetoprotein (AFP) i le Toto [faʻafouina 2016 Jun 30; taʻua 2017 Jun 5]; [pe a ma le 5 pupuni] Avanoa mai: https://www.uwhealth.org/health/topic/medicaltest/alpha-fetoprotein-afp-in-blood/hw1663.html
- UW Soifua Maloloina [Initaneti]. Madison (WI): Iunivesite o Wisconsin Falemai ma Falemai Pulega; c2017. Faʻamatalaga o le Soifua Maloloina: Triple poʻo Quad Screening mo Birth Defects [faʻafouina 2016 Jun 30; taʻua 2017 Jun 5]; [pe a ma le 5 pupuni] Avanoa mai: https://www.uwhealth.org/health/topic/special/maternal-serum-triple-or-quadruple-screening-test/ta7038.html#ta7038-sec
O faʻamatalaga i luga o lenei 'upega tafaʻilagi e le tatau ona faʻaaogaina e fai ma sui o fomaʻi faʻapitoa togafitiga poʻo fautuaga. Faʻafesoʻotaʻi le au tausi soifua pe a iai ni au fesili e uiga i lou soifua maloloina.