CPK isoenzymes suʻega

O le Creatine phosphokinase (CPK) isoenzymes suʻega e fuaina ai ituaiga eseese o CPK i le toto. CPK o se enzyme e maua tele i le fatu, faiʻai, ma auivi maso.

E manaʻomia se faʻataʻitaʻiga ole toto. Lenei ono mafai ona aveʻesea mai se uaua. O le suʻega e taʻua o le venipuncture.

Afai o loʻo e i le falemaʻi, e ono faʻaauau lenei suʻega ile 2 poʻo le 3 aso. Ole taua tele pe paʻu ile aofaʻi ole CPK poʻo le CPK isoenzymes e mafai ona fesoasoani i lau fomaʻi faʻapitoa e suʻesuʻe nisi tulaga.

Leai se faʻapitoa sauniuniga e manaʻomia i le tele o tulaga.

Taʻu i lau kamupani e uiga i vailaʻau uma o loʻo inu. O nisi vailaʻau e mafai ona faʻalavelave i iʻuga o suʻega. Fualaʻau e mafai ona faʻateleina CPK fuaina aofia ai mea nei:

• Ava Malosi
• Amphotericin B
• Nisi vai faagase
• Cocaine
• Fibrate fualaʻau
• Statins
• Steroids, pei o le dexamethasone

O lenei lisi e leʻo aofia uma ai.

Atonu e te lagonaina sina tiga pe a tuu le nila i le toto. O nisi tagata e naʻo se tuitui poʻo se lagona tiga e lagonaina. A maeʻa, atonu e i ai ni faʻagatete.

O lenei suʻega e faia pe a fai o se suʻega CPK faʻaalia ai o lau aofaʻi atoa tulaga CPK ua siitiaina. Ole suʻega ole CPK isoenzyme e mafai ona fesoasoani e suʻe tonu le mafuaʻaga o mea ua leaga.

CPK e faia i ni mea laiti eseese e tolu:

• CPK-1 (e taʻua ole CPK-BB) e tele na maua ile faiʻai ma mama
• CPK-2 (e taʻua ole CPK-MB) e maua tele ile fatu
• CPK-3 (e taʻua ole CPK-MM) e tele na maua ile auivi ole auivi

Maualuga-nai lo-masani tulaga CPK-1:

Talu ai o le CPK-1 e tele na maua i le faiʻai ma mama, o le manuʻa i se tasi o nei itu e mafai ona faʻateleina ai le CPK-1. Faʻateleina CPK-1 tulaga ono mafua mai i:

• Kanesa o le faiʻai
• Manua o le faiʻai (ona o soʻo se ituaiga o manuʻa aofia ai, stroke, po o le toto i le faiʻai)
• Togafitiga eletise
• Faʻamaʻa o le pulmonary
• Faoa faamalosi

Maualuga-nai lo-masani tulaga CPK-2:

CPK-2 tulaga tulaʻi mai 3 i le 6 itula pe a maeʻa le fatu fatu. Afai e leai se toe afaina fatu maso, o le tulaga tumutumu tumutumu i 12 i le 24 itula ma toe foi i le masani 12 i le 48 itula pe a maeʻa oti tino.

Faʻateleina le CPK-2 tulaga ono mafua mai foi i:

• Manuʻaga eletise
• Loto defibrillation (faamoemoe faʻateʻia o le fatu e fomaʻi tagata faigaluega)
• Manua o le fatu (mo se faʻataʻitaʻiga, mai se faʻalavelave tau taʻavale)
• Fula o le fatu maso masani ona o se siama (myocarditis)
• Tatala taotoga fatu

Maualuga-nai lo-masani tulaga CPK-3 e masani ona avea ma faʻailoga o maso manua poʻo maso popolevale. Atonu e mafua ona:

• Tuʻimomomo manuʻa
• Faʻaleagaina maso ona o vailaʻau faʻasaina poʻo le le minoi mo se taimi umi (rhabdomyolysis)
• Faʻaleagaina musele
• Myositis (fulafula maso maso)
• Mauaina tele tui intramuscular
• Talu ai nei neivi ma maso galuega tauave tofotofoga (electromyography)
• Faoa faamalosi talu ai nei
• Talu ai nei taotoga
• Faamalositino malosi

O mea e mafai ona aʻafia ai faʻaiuga o suʻega e aofia ai le faʻamaʻiina o le fatu, tuiina i totonu o le toto, taotoga talu ai nei, ma le malosi ma faʻamalositino umi poʻo le faʻamalosi tino.

Isoenzyme suʻega mo ni tuutuuga maoti e tusa ma le 90% saʻo.

Creatine phosphokinase - isoenzymes; Creatine kinase - isoenzymes; CK - isoenzymes; Maʻi fatu - CPK; Tipi - CPK

• Tofotofoga toto

Anderson JL. St vaega faʻamalosia matuitui myocardial infarction ma faʻafitauli o myocardial infarction. I totonu: Goldman L, Schafer AI, eds. Faʻafomaʻi Goldman-Cecil. 25th lomiga. Filatelefaia, PA: Elsevier Saunders; 2016: mata 73.

Marshall WJ, Day A, Lapsley M. Plasma proteins ma enzymes. I: Marshall WJ, Aso A, Lapsley M, eds. Vailaau Togafitiga. 8th ed. Filatelefia, PA: Elsevier; 2017: mata 16

Nagaraju K, Gladue HS, Lundberg IE. Faamai faʻamaʻi o maso ma isi myopathies. I totonu: Firestein GS, Budd RC, Gabriel SE, McInnes IB, O'Dell JR, eds. Kelley ma Firestein's Tusitusiga o Rheumatology. 10 ed. Filatelefaia, PA: Elsevier Saunders; 2017: mata 85.

Selcen D. Faʻamaʻi maso. I totonu: Goldman L, Schafer AI, eds. Faʻafomaʻi Goldman-Cecil. 25th lomiga. Filatelefaia, PA: Elsevier Saunders; 2016: mata 421.