Felty syndrome

O le Felty syndrome o se faʻamaʻi e aofia ai ma le gugu rheumatoid, o le faʻaputuga fulafula, faʻaititia le paʻepaʻe o le toto papaʻe, ma faʻamaʻi faifai pea. E seasea tupu.

E le o iloa le mafuaʻaga o le Felty syndrome. E taatele i tagata ua leva na maua ile rheumatoid arthritis (RA). O tagata e maua i lenei faʻamaʻi e lamatia i le faʻamaʻi, ona e maualalo le paʻepaʻe o le toto papaʻe.

Faʻailoga aofia ai:

• Lagona lautele o le le mautonu (malaise)
• Le lavava
• Vaivaiga i le vae po o le lima
• Leai o le fiaai
• Leiloa leiloa mamafa mamafa
• O papala i le paʻu
• Fula soʻoga, malo, tiga, ma le paʻu
• Faʻamaʻi pipisi
• Mata mumu ma le mu pe lafoaʻi

O le a faʻaalia se suʻega faʻaletino:

• Lafoa fulafula
• Tuʻufaʻatasia e faʻaalia ai faʻailoga o le RA
• Atonu ua fulafula le ate ma lymph nodes

O le aofaʻi atoa o le toto (CBC) ma le eseesega o le a faʻaalia ai le maualalo o numera paʻepaʻe toto e taʻua o neutrophils. Toeititi lava o tagata uma e maua i le Felty syndrome o loʻo iai se faʻataʻitaʻiga lelei mo le rheumatoid factor.

O le ultrasound manava mafai faʻamaonia se fulafula vae.

I le tele o tulaga, o tagata e maua i lenei faʻamaʻi e le o mauaina ni togafitiga fautuaina mo le RA. Atonu latou te manaʻomia isi vailaʻau e tineia ai a latou tino puipuia ma faʻaititia ai gaioiga ole latou RA.

Methotrexate mafai faʻaleleia le maualalo neutrophil faitau. O le vailaʻau rituximab ua faʻamanuiaina i tagata latou te le tali atu i le methotrexate.

Granulocyte-colony stimulate factor (G-CSF) ono siʻi le numera neutrophil.

Nisi tagata faʻamanuiaina mai le aveʻesea o le spleen (splenectomy).

A aunoa ma togafitiga, faʻamaʻi ono mafai ona tupu pea.

E ono atili ai ona leaga le RA.

Peitai, o le togafitia o le RA, e tatau ona faaleleia ai le Felty syndrome.

E i ai faʻamaʻi e te toe foʻi mai.

O nisi tagata e maua i le Felty syndrome ua faʻateleina le aofaʻi o lymphocytes lapoʻa, ua taʻua foi ole LGL leukemia. Lenei o le a togafitia ma methotrexate i le tele o tulaga.

Valaʻau lau fomaʻi pe a fai e te maua faʻailoga o lenei faʻamaʻi.

O le vave togafitiga o le RA ma vailaʻau fautuaina ile taimi nei, ua matuaʻi faʻaititia ai le aʻafiaga o le Felty syndrome.

Seropositive rheumatoid gugu (RA); Felty's syndrome

• Antibodies

Bellistri JP, Muscarella P. Splenectomy mo faʻamai o le hematologic. I: Cameron JL, Cameron AM, eds. Togafitiga i le taimi nei. 12th lomiga. Filatelefia, PA: Elsevier; 2017: 603-610.

Erickson AR, Cannella AC, Mikuls TR. Vaʻaiga togafitiga o gugu rheumatoid. I totonu: Firestein GS, Budd RC, Gabriel SE, McInnes IB, O'Dell JR, eds. Kelley ma Firestein's Tusitusiga o Rheumatology. 10 ed. Filatelefia, PA: Elsevier; 2017: mata 70.

Gazitt T, Loughran TP Jr Chronic neutropenia i le LGL leukemia ma le gugu roma. Hematology Am Soc Hematol Educ Program. 2017; 2017 (1): 181-186. PMID: 29222254 www.ncbi.nlm.nih.gov/pubmed/29222254.

Myasoedova E, Turesson C, Matteson EL. Extraarticular foliga o rheumatoid gugu. I: Hochberg MC, Gravallese EM, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH, eds. Rheumatology. 7th ed. Filatelefia, PA: Elsevier; 2019: mata 95.

Savola P, Brück O, Olson T, et al. Somatic STAT3 fesuiaiga i le Felty syndrome: o se aafiaga mo se masani pathogenesis ma tele granular lymphocyte leukemia. Haematologica. 2018; 103 (2): 304-312. PMID: 29217783 www.ncbi.nlm.nih.gov/pubmed/29217783.

Wang CR, Chiu YC, Chen YC. Manuia togafitiga o refactory neutropenia i Felty's syndrome ma rituximab. Scand J Rheumatol. 2018; 47 (4): 340-341. PMID: 28753121 www.ncbi.nlm.nih.gov/pubmed/28753121.