BRCA Genetic Test

Anotusi

• O le a le suʻega ole genes ole BRCA?
• O le a le mea e faʻaaoga ai?
• Aisea oute manaʻomia ai se suʻega ole gafa ole BRCA?
• Ole a le mea e tupu ile taimi ole suʻega ole gafa ole BRCA?
• Mata e tatau ona ou faia se mea e sauniuni ai mo le suʻega?
• E i ai ni lamatiaga i le suʻega?
• O le a le uiga o faʻaiuga?
• E i ai seisi mea e tatau ona ou iloa e uiga i le BRCA faʻamaoniga o gafa?
• Faʻamatalaga

O le a le suʻega ole genes ole BRCA?

O le suʻega ole genes ole BRCA e suʻesuʻe ai suiga, e taʻua o fesuiaʻiga, i kenera e taʻua o le BRCA1 ma le BRCA2. O kenera o ni vaega o DNA na faʻasolo mai i lou tina ma lou tama. Latou te aveina faʻamatalaga e iloa ai ou uiga tulaga ese, pei o le maualuga ma le lanu o mata. O Kenese e gafa foʻi ma nisi tulaga tau le soifua maloloina. BRCA1 ma BRCA2 o kenera e puipuia sela e ala i le faia o polotini e fesoasoani puipuia tumors mai le fausiaina.

O le fesuiaiga i le BRCA1 poʻo le BRCA2 gene e ono mafua ai le faʻaleagaina o sela e ono iʻu ai i le kanesa. Tamaʻitaʻi ma le genetasi BRCA suia ua i ai le maualuga aʻafiaga o le mauaina o le susu poʻo le ovarian kanesa. O tamaloloa e iai le genated BRCA gene o loʻo tele le avanoa e maua ai ile kanesa o le susu poʻo le prostate. E le o tagata uma e mauaina le BRCA1 poʻo le BRCA2 suiga o le a maua i le kanesa. O isi mea, e aofia ai lou ituaiga olaga ma lau siʻosiʻomaga, mafai ona afaina ai lou kanesa lamatiaga.

A faʻapea ua e maua le fesuiaiga o le BRCA, e ono mafai ona e faia ni laʻasaga e puipuia ai lou soifua maloloina.

Isi igoa: BRCA gene test, BRCA gene 1, BRCA gene 2, susu kanesa susceptibility gene1, susu kanesa susceptibility gene 2

O le a le mea e faʻaaoga ai?

O lenei suʻega e faʻaaogaina e suʻe ai pe o iai sau fesuiaʻiga o le kenera BRCA1 poʻo le BRCA2. O le BRCA gene mutation e mafai ona faʻateleina ai lou ono maua i le kanesa.

Aisea oute manaʻomia ai se suʻega ole gafa ole BRCA?

BRCA suʻega e le fautuaina mo le tele o tagata. BRCA gene mutations e seasea tupu, afaina ai na o le 0.2 pasene o le US faitau aofaʻi. Ae oe ono manaʻomia lenei suʻega pe a fai e te manatu o oe i se sili atu lamatiaga o le i ai o le suiga. E te ono maua se fesuiaʻiga o le BRCA pe a fai o oe:

• Maua pe na maua i le kanesa kanesa na faʻamaonia muamua ae leʻi 50 tausaga
• Maua pe na maua i le kanesa kanesa i uma uma susu
• Maua pe na maua uma le kanesa o le susu ma ovarian
• Maua se tasi pe sili atu tagata o le aiga ua maua i le kanesa o le susu
• Ia i ai se tamaloa aiga ma le kanesa o le susu
• Maua se tasi aiga ua uma ona faʻamaonia i le BRCA suiga
• O i latou o Ashkenazi (Sasaʻe Europa) tupuʻaga Iutaia. BRCA fesuiaiga e sili atu ona taatele i lenei vaega faʻatusatusa i le lautele o tagata. BRCA fesuiaiga e tele foi taatele i tagata mai isi itu o Europa, aofia ai, I Island, Nouei, ma Tenimaka.

Ole a le mea e tupu ile taimi ole suʻega ole gafa ole BRCA?

O le polofesa mo le soifua maloloina o le a ave se toto faʻataʻitaʻiga mai se uaua i lou lima, faʻaaoga ai se tamaʻi nila. A maeʻa ona tuʻu i totonu le nila, o le a faʻaputuputuina se vaega laʻititi o le toto i totonu o se faʻamaoniga poʻo se ipu. Atonu e te lagonaina sina tiga pe a alu le nila i totonu pe fafo. Lenei masani ona alu ifo i lalo o le lima minute.

Mata e tatau ona ou faia se mea e sauniuni ai mo le suʻega?

E te le manaʻomia ni sauniuniga faʻapitoa mo suʻega BRCA. Ae atonu e te manaʻo e feiloaʻi muamua ma se faufautua o kenera e vaai pe talafeagai le suʻega mo oe. Atonu e talanoa lau faufautua ma oe e uiga i mea lamatia ma penefiti o le suesueina o le kenera, ma uiga eseese e ono uiga iai.

E tatau foi ona e mafaufau e uiga i le mauaina o faufautua faufautua pe a maeʻa lau suʻega. E mafai e lau faufautua ona talanoaina pe faʻafefea ona aʻafia oe ma lou aiga i au faʻaiuga, i togafitiga ma le mafaufau.

E i ai ni lamatiaga i le suʻega?

E laʻititi lava le aʻafia ile faia ole suʻega ile toto. E i ai sina tiga poʻo se tiga i le mea na tuu ai le nila, ae o le tele o faʻailoga e vave ona alu ese.

O le a le uiga o faʻaiuga?

Ole tele o iʻuga e faʻamatalaina e le lelei, le mautinoa, pe lelei, ma e masani ona faʻapea:

• O se iʻuga le lelei lona uiga e leai se BRCA gene mutation na maua, ae le faʻapea e te le maua loa kanesa.
• O se iʻuga le mautinoa lona uiga o se ituaiga BRCA gene mutation na maua, ae ono mafai pe fesoʻotaʻi ma le faʻateleina tulaga kanesa. Atonu e te manaʻomia nisi suʻega ma / pe mataituina pe a fai e le mautinoa au iʻuga.
• O se iʻuga lelei o lona uiga na maua se suiga i le BRCA1 poʻo le BRCA2. O nei fesuiaʻiga e te maua ai i se maualuga maualuga aʻafiaga o le kanesa. Ae le o tagata uma ma le fesuiaiga maua kanesa.

Atonu e tele ni vaiaso e maua ai au iʻuga. A iai ni au fesili e uiga i au iʻuga, talanoa i lau fomaʻi ma / poʻo lau fesoasoani i le kenera.

Aʻoaʻo atili e uiga i suʻesuʻega falesuesue, vaitau o faʻasino, ma malamalamaaga i iʻuga

E i ai seisi mea e tatau ona ou iloa e uiga i le BRCA faʻamaoniga o gafa?

Afai o faʻaiuga ua faʻaalia ai o loʻo iai sau fesuiaʻiga o le gafa o le BRCA, e mafai ona e uia ni laʻasaga e ono tuʻu ai i lalo lou ono maua i le kanesa o le susu. E aofia ai:

• Ole tele o taimi ole suʻega ole kanesa, pei ole mammograms ma ultrasounds. Kanesa e faigofie ona togafitia pe a maua i le amataga o laʻasaga.
• Aveina o fualaʻau fomaʻi mo se taimi faatapulaa. O le inuina o fualaʻau taofi tamaiti mo le maualuga o le lima tausaga ua faʻaalia e faʻaititia ai le aʻafia o le kanesa o le ovarian i nisi fafine e iai fesuiaʻiga o gaʻo o le BRCA. O le inuina o fualaʻau mo le sili atu ma le lima tausaga e faʻaititia ai le kanesa e le fautuaina. Afai o loʻo inu sau fualaʻau fualaʻau ae e leʻi faia le suʻega ole BRCA, taʻu i lau fomaʻi pe fia ou tausaga na amata ai ona inu fualaʻau ma poʻo le a le umi. O le a ia fautuaina pe tatau ona faʻaauau pea ona e aveina pe leai.
• Inumaga o vailaʻau o le kanesa. O vailaʻau faʻapitoa, pei o le tasi e taʻua ole tamoxifen, ua faʻaalia e faʻaititia ai le aʻafiaga o fafine e maualuga le aʻafiaga o le kanesa o le susu.
• O le faia o se taʻotoga, e taʻu ole mastectomy e puipuia ai, e aveʻese ai le soifua maloloina o le susu. O le puipuiga ole mastectomy ua faʻaalia e faʻaititia ai le kanesa o le susu i le sili atu i le 90 pasene i fafine ma le BRCA gene mutation. Ae o se faʻagaioiga tele lea, naʻo le fautuaina mo fafine e maualuga le lamatiaga mo le mauaina o le kanesa.

E tatau ona e talanoa ma lau fomaʻi e vaai poʻo a laʻasaga e sili mo oe.

Faʻamatalaga

1. American Society of Clinical Oncology [Initaneti]. American Sosaiete o Togafitiga Oncology; 2005-2018. Fanau Fafu ma Kanesa kanesa; [taʻua 2018 Mati 19]; [pe tusa ma le 3 pupuni] Avanoa mai: https://www.cancer.net/cancer-types/hereditary-breast-and-ovarian-cancer
2. Hinkle J, Cheever K. Brunner & Suddarth's Handbook of Laboratory and Diagnostic Tests. 2nd Ed, faamumū. Filatelefaia: Wolters Kluwer Soifua Maloloina, Lippincott Williams & Wilkins; c2014. BRCA Suʻega; 108 itu.
3. Lab Tofotofoga lugalaina [Initaneti]. Washington D.C .: American Association mo Vailaʻau Togafitiga; c2001–2018. BRCA Gene Mutation Testing [toe faafou 2018 Ian 15; taʻua 2018 Fepuari 23]; [pe a ma le 2 pupuni] Avanoa mai: https://labtestsonline.org/tests/brca-gene-mutation-testing
4. Mayo Clinic [Initaneti]. Mayo Faʻavae mo Aʻoga Faʻafomaʻi ma Suesuega; c1998–2018. BRCA gene test mo le kanesa o le susu ma ovarian tulaga lamatia; 2017 Tes 30 [taʻua 2018 Feb 23]; [pe tusa ma le 3 pupuni] Avanoa mai: https://www.mayoclinic.org/tests-procedures/brca-gene-test/about/pac-20384815
5. Faʻamanatuga Sloan Kettering Cancer Center [Initaneti]. Niu Ioka: Faʻamanatuga Sloan Kettering Cancer Center; c2018. BRCA1 ma le BRCA2 Genes: Tulaga lamatia mo le kanesa o le susu ma ova [taʻua 2018 Fep 23 23]; [pe a ma le 5 pupuni] Avanoa mai: https://www.mskcc.org/cancer-care/risk-assessment-screening/hereditary-genetics/genetic-counseling/brca1-brca2-genes-risk-breast-ovarian
6. National Cancer Institute [Initaneti]. Bethesda (MD): U.S. Matagaluega o le Soifua Maloloina ma Tagata Auaunaga; BRCA Mutations: Kanesa Faʻataʻitaʻi ma Genetic Testing [taʻua 2018 Fep 23 23]; [pe tusa ma le 3 pupuni] Avanoa mai: https://www.cancer.gov/about-cancer/causes-prevention/genetics/brca-fact-sheet#q1
7. National Cancer Institute [Initaneti]. Bethesda (MD): U.S. Matagaluega o le Soifua Maloloina ma Tagata Auaunaga; NCI Dictionary of Cancer Terms: fesuiaʻiga [taʻua 2018 Fep 23 23]; [pe tusa ma le 3 pupuni] Avanoa mai: https://www.cancer.gov/publications/dictionaries/cancer-terms/search?contains=false&q;=mutation
8. National Heart, Lung, and Blood Institute [Initaneti]. Bethesda (MD): U.S. Matagaluega o le Soifua Maloloina ma Tagata Auaunaga; Tofotofoga Toto [taʻua 2018 Fep 23]; [pe tusa ma le 3 pupuni] Avanoa mai: https://www.nhlbi.nih.gov/health-topics/blood-tests
9. NIH U.S. National Library of Medicine: Genetics Home Reference [Initaneti]. Bethesda (MD): U.S. Matagaluega o le Soifua Maloloina ma Tagata Auaunaga; BRCA1 gene; 2018 Mar 13 [taʻua le 2018 Mar 18]; [pe tusa ma le 3 pupuni] Avanoa mai: https://ghr.nlm.nih.gov/gene/BRCA1#conditions
10. NIH U.S. National Library of Medicine: Genetics Home Reference [Initaneti]. Bethesda (MD): U.S. Matagaluega o le Soifua Maloloina ma Tagata Auaunaga; BRCA2 gene; 2018 Mar 13 [taʻua le 2018 Mar 18]; [pe tusa ma le 3 pupuni] Avanoa mai: https://ghr.nlm.nih.gov/gene/BRCA2#conditions
11. NIH U.S. National Library of Medicine: Genetics Home Reference [Initaneti]. Bethesda (MD): U.S. Matagaluega o le Soifua Maloloina ma Tagata Auaunaga; O le a le mea e taʻu o le kenera?; 2018 Fepuari 20 [taʻua 2018 Fep 23]; [pe tusa ma le 3 pupuni] Avanoa mai: https://ghr.nlm.nih.gov/primer/basics/gene
12. Iunivesite o Rochester Medical Center [Initaneti]. Rochester (NY): Iunivesite o Rochester Medical Center; c2018. Health Encyclopedia: BRCA [taʻua 2018 Fep 23 23]; [pe a ma le 2 pupuni] Avanoa mai: https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=167&contentid;=brca
13. UW Soifua Maloloina [Initaneti]. Madison (WI): Iunivesite o Wisconsin Falemai ma Falemai Pulega; c2018. Breast Cancer (BRCA) Gene Test: Faʻafefea ona Saunia [toe faʻafou 2017 Jun 8; taʻua 2018 Fepuari 23]; [pe a ma le 5 pupuni] Avanoa mai: https://www.uwhealth.org/health/topic/medicaltest/breast-cancer-brca-gene-test/tu6462.html#tu6465
14. UW Soifua Maloloina [Initaneti]. Madison (WI): Iunivesite o Wisconsin Falemai ma Falemai Pulega; c2018. Breast Cancer (BRCA) Gene Test: Iʻuga [toe faʻafouina 2017 Jun 8; taʻua 2018 Fepuari 23]; [pe a ma le 9 pupuni] Avanoa mai: https://www.uwhealth.org/health/topic/medicaltest/breast-cancer-brca-gene-test/tu6462.html#tu6469
15. UW Soifua Maloloina [Initaneti]. Madison (WI): Iunivesite o Wisconsin Falemai ma Falemai Pulega; c2018. Kanesa o le Fatafata (BRCA) Gene Suʻega: Suʻesuʻega o Vaaiga [toefaʻaleleia 2017 Jun 8; taʻua 2018 Fepuari 23]; [pe a ma le 2 pupuni] Avanoa mai: https://www.uwhealth.org/health/topic/medicaltest/breast-cancer-brca-gene-test/tu6462.html
16. UW Soifua Maloloina [Initaneti]. Madison (WI): Iunivesite o Wisconsin Falemai ma Falemai Pulega; c2018. Breast Cancer (BRCA) Gene Tofotofoga: Aisea Ua Faia ai [faafou 2017 Jun 8; taʻua 2018 Fepuari 23]; [tusa o le 4 pupuni] Avanoa mai: https://www.uwhealth.org/health/topic/medicaltest/breast-cancer-brca-gene-test/tu6462.html#tu646

O faʻamatalaga i luga o lenei 'upega tafaʻilagi e le tatau ona faʻaaogaina e fai ma sui o fomaʻi faʻapitoa togafitiga poʻo fautuaga. Faʻafesoʻotaʻi le au tausi soifua pe a iai ni au fesili e uiga i lou soifua maloloina.