Faʻatele faiga atrophy - cerebellar subtype

Ole tele ole atrophy ole faʻavae - cerebellar subtype (MSA-C) o se faʻamaʻi seasea e mafua ai vaega loloto o le faiʻai, i luga aʻe o le uaula, e faʻapipiʻi ai (atrophy). MSA-C sa masani ona taʻua o le olivopontocerebellar atrophy (OPCA).

MSA-C mafai ona pasi i lalo i aiga (tofi faʻavae). E mafai foi ona aʻafia ai tagata e aunoa ma se lauiloa o aiga talaʻaga (sporadic form).

Ua faʻailoa mai e le au suʻesuʻe nisi o genes o loʻo aʻafia ile tofi faʻavae o lenei tulaga.

O le mafuaʻaga o le MSA-C i tagata ma le sporadic form e le o iloa. O le faʻamaʻi e faifai malie ona leaga (e alualu i luma).

MSA-C e fai si masani i tagata nai lo fafine. Ole averesi ole tausaga ole amataga e 54 tausaga le matua.

Faʻailoga o le MSA-C foliga mai e amata i se talavou tausaga i tagata ma le tofi tofi. O le faʻailoga iloga o le clumsiness (ataxia) e faifai malie ona leaga. Atonu e iai foʻi faʻafitauli ile paleni, faʻaletonu ole tautala, ma faigata ona savali.

O isi faʻailoga e mafai ona aofia ai:

• Le masani o gaioiga o mata
• Gaioiga le masani ai
• Faʻafitauli o le manava pe manava
• Faigata faʻaumatia
• Malulu lima ma vae
• Malamalama ao tu i luga
• Ulu le ulu a o tu lena e mapu i le taoto i lalo
  
• Faʻaʻaʻa maso poʻo le maʻaʻa, tiga o le tino, gatete
• Faʻaleagaina neula (neuropathy)
• Faʻafitauli i le tautala ma moe ona o spasms o leo leo
• Faʻafitauli tau feusuaiga
• O le afu e le masani ai

O se suʻesuʻega maeʻaeʻa o togafitiga faafomai ma neula, e iai foi ma le toe iloiloga o faʻailoga ma talafaʻasolopito o aiga e manaʻomia e faia ai le faʻamaʻi

E iai suʻega ole kenera e vaʻai ai mo mafuaʻaga o nisi ituaiga ole faʻamaʻi. Ae, e leai se faʻapitoa suʻesuʻega e avanoa i le tele o tulaga. O le MRI o le faiʻai e mafai ona faʻaalia suiga i le tele o afaina faiai faiʻai, aemaise lava o le faʻamaʻi ua atili ai ona leaga. Ae mafai ona maua le faʻamaʻi ma maua se MRI masani.

O isi suʻega e pei o le positron emission tomography (PET) e mafai ona faia e faʻateʻa ai isi tulaga. E ono aofia ai le foloina o suʻesuʻega e iloa ai pe mafai e se tagata ona folo lemu meaai ma le vai.

E leai se togafitiga faʻapitoa poʻo se fofo mo MSA-C. O le faʻamoemoe o le togafitia o faʻailoga ma puipuia faʻalavelave. E mafai ona aofia ai:

• Faʻafefe vailaʻau, pei o na mo Parkinson faʻamaʻi
• Tautalaga, galuega ma faʻamalositino togafitiga
• Auala e aua ai le fetinaʻi
• Savali fesoasoani e fesoasoani i le paleni ma puipuia pa'ū

O kulupu nei e mafai ona tuʻuina atu iai fesoasoani ma lagolago mo tagata e iai le MSA-C:

• Faʻatoʻilaloina le MSA Alliance - toilaloʻa.org/patient-programs/
• Le MSA Coalition - www.multceptsystematrophy.org/msa-resource/

E faasolosolo lava ina leaga le MSA-C, ma e leai se togafiti. O le vaʻaiga e matitiva lava. Ae, atonu e tele tausaga ae le i atoatoa le malosi o se tasi.

Faʻafitauli o le MSA-C aofia ai:

• Taoa
• Siama mai le manavaina o meaai i totonu o mama (aspiration niumonia)
• Manua mai le afu
• Faʻafitauli paleni ona o le faigata ona folo

Valaʻau lau fomaʻi pe a iai ni faʻailoga o le MSA-C. Oe o le a manaʻomia e vaʻaia e se fomaʻi o neura. Ole fomaʻi lenei e togafitia faʻafitauli ole neula.

MSA-C; Cerebellar tele faiga atrophy; Olivopontocerebellar atrophy; OPCA; Olivopontocerebellar faʻaleagaina

• Nofoʻaga popolevale ma faiga lautele neula

Ciolli L, Krismer F, Nicoletti F, Wenning GK. O se faʻafouga luga o le cerebellar subtype o le tele o faʻataʻitaʻiga faiga. Cerebellum Ataxias. 2014; 1-14. PMID: 26331038 pubmed.ncbi.nlm.nih.gov/26331038/.

Gilman S, Wenning GK, Low PA, et al. Lua faamatalaga autasi i luga o le faʻamaoniga o le tele faʻafitauli faiga. Neurology. 2008; 71 (9): 670-676. PMID: 18725592 pubmed.ncbi.nlm.nih.gov/18725592/.

Jancovic J. Parkinson faamaʻi ma isi gasegase le atoatoa. I totonu: Daroff RB, Jankovic J, Mazziotta JC, Pomeroy SL, eds. Bradley's Neurology i Fomaʻi Faʻataʻitaʻi. 7th ed. Filatelefia, PA: Elsevier; 2016: mata 96.

Ma MJ. Biopsy pathology o neurodegenerative faʻafitauli i tagata matutua. I totonu: Perry A, Brat DJ, eds. Neuropathology taotoga faʻatinoina: Ose Suʻega Suʻesuʻe. 2nd ed. Filatelefia, PA: Elsevier, 2018: mata 27.

Walsh RR, Krismer F, Galpern WR, et al. Fautuaga o le lalolagi lautele tele faʻafanua atrophy suʻesuʻega fonotaga auala. Neurology. 2018; 90 (2): 74-82. PMID: 29237794 pubmed.ncbi.nlm.nih.gov/29237794/.