Aiga faʻapitoa

Fambial dysbetalipoproteinemia o se faʻamaʻi pasi mai aiga. E mafua ai le maualuga o kolesterol ma triglycerides i le toto.

O se faaletonu tupuʻaga mafua ai lenei tulaga. O le faʻaletonu e mafua ai le faʻaputuina o vaega lapoʻa o le lipoprotein o loʻo i ai uma vaega o le kolesterol ma le ituaiga gaʻo e taʻua o triglycerides. O le faʻamaʻi e fesoʻotaʻi ma faaletonu i le gafa mo apolipoprotein E.

O le hypothyroidism, lapoʻa, poʻo le maʻisuka e mafai ona atili ai ona leaga le tulaga. O mea e ono lamatia ai le aiga faʻamaʻi dysbetalipoproteinemia aofia ai le talaʻaga aiga o le faʻamaʻi poʻo le faʻamaʻi o le alatoto.

Faʻailoga atonu e le vaʻaia seʻia 20 tausaga pe sili atu.

O tupe teu samasama o mea gaʻo i le paʻu e taʻua ole xanthomas e mafai ona aliali mai i luga o laumata, alofilima, alofivae, pe i luga o sooga o tulivae ma tulilima.

O isi faʻailoga e mafai ona aofia ai:

• Paʻu o le fatafata (angina) poʻo isi faʻailoga o le gasegase o le alatoto e maua i taimi o loʻo talavou
• Faʻapipiʻi se tasi poʻo tamaʻi povi peʻa savali
• E tiga o tamatamaivae e le malolo
• Faʻafuaseʻi pei o le faʻamaʻi pei o faʻafitauli ile tautala, paʻu ile tasi itu ole mata, vaivaiga ole lima poʻo le vae, ma le leiloa o paleni.

O suʻega e mafai ona faia e suʻesuʻe ai lenei tulaga e aofia ai:

• Suʻega faʻafuaseʻi mo apolipoprotein E (apoE)
• Suʻega toto ole vaega ole lipid
• Triglyceride tulaga
• Maualalo tele density lipoprotein (VLDL) suʻega

O le faʻamoemoe o togafitiga o le faʻatonutonuina o tulaga pei o le lapoʻa, hypothyroidism, ma le maʻisuka.

O le faia o suiga o meaʻai e faʻaititia ai kalori, gaʻo gaʻo, ma le kolesterol e ono fesoasoani e faʻaititia ai le toto suka

A faʻapea e maualuga pea le maualuga ole kolisi ma le triglyceride pe a maeʻa ona e faia suiga o meaʻai, e ono faʻatonuina foi oe e lau fomaʻi. O vailaʻau e tuʻu ai i lalo le toto triglyceride ma tulaga o le kolisi e aofia ai:

• Bile acid-faʻasologa resins.
• Fibrates (gemfibrozil, fenofibrate).
• Oona suavaia
• Statins.
• O mea taofiofi ole PCSK9, pei ole alirocumab (Praluent) ma le evolocumab (Repatha). O nei sui o se fou vasega vasega o vailaʻau e togafitia cholesterol.

Tagata ma lenei tulaga ua i ai se matua faateleina le tulaga lamatia mo coronary alatoto ala ma peripheral vascular faamai.

Faʻatasi ai ma togafitiga, tele o tagata e mafai ona faʻaititia tele latou tulaga o kolesterol ma triglycerides.

Faʻafitauli e ono aofia ai:

• Maʻi fatu
• Pa
• Faʻamaʻi vaskular peripheral
• Faʻasao le motusia
• Gangrene o pito i lalo

Valaʻau lau tautua pe a fai oe ua maua i lenei maʻi ma:

• Ua tupu aʻe ni faʻailoga fou.
• Faʻailoga e le faʻaleleia atili i togafitiga.
• Faʻailoga e atili ai ona leaga.

O le suʻesuʻeina o tagata o aiga o tagata e maua i lenei tulaga e ono taitai atu ai i le vave mauaina ma togafitiga.

O le vave togafitia ma faʻatapulaʻa isi tulaga lamatia e pei o le ulaula e mafai ona fesoasoani e puipuia vave fatu fatu, afaina, ma poloka toto toto.

Ituaiga III hyperlipoproteinemia; Le lava pe le lelei apolipoprotein E.

• Faʻamaʻi o alatoto toto

Genest J, Libby P. Lipoprotein faʻafitauli ma faʻamaʻi fatu. I: Zipes DP, Libby P, Bonow RO, Mann DL, Tomaselli GF, Braunwald E, eds. Braunwald's Heart Disease: O Se Tusitusiga o Faʻafomaʻi Cardiovascular. 11th lomiga. Filatelefia, PA: Elsevier; 2019: chap 48.

Robinson JG. Faʻaletonu o le lipid metabolism. I totonu: Goldman L, Schafer AI, eds. Faʻafomaʻi Goldman-Cecil. 26th lomiga. Filatelefia, PA: Elsevier; 2020: chap 195.